Linzess medication for IBS and chronic constipation

Linzess (linaclotide) relieves symptoms of irritable bowel syndrome with constipation (IBS) and chronic constipation. Speak with a top-rated, board-certified doctor about getting a new prescription or refill of Linzess online, and find relief from abdominal discomfort today.*

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#1 Prescribed IBS and chronic constipation medication

Ease constipation, abdominal pain, bloating, and more

Request Linzess in as little as 15 minutes, with or without insurance*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

What is Linzess, and how does it work?

  • Linzess treats chronic constipation, irritable bowel syndrome (IBS), and abdominal pain symptoms. It increases the fluid in your intestines, which helps accelerate food movement through the gut. It can also improve stool texture and lessen gastrointestinal reactions, such as bloating.

    • Gentle constipation relief: Linzess softens stool, easing chronic constipation discomfort.

    • Starts working quickly: Linzess has a relatively fast onset, with some individuals experiencing relief from constipation within a few days.

    • Ease abdominal discomfort: Linzess relieves abdominal pain and other uncomfortable GI symptoms.

  • Linzess side effects

    Common side effects of Linzess include:




  • Other side effects, which are less common but might be more severe, could include:

    Dizziness or light-headedness

    Abdominal Pain

    Allergic reactions

    Upper respiratory tract infection medication

    You should schedule an appointment with our board-certified virtual doctors if you notice any adverse effects or develop other new or concerning symptoms.

    Severe diarrhea can increase your risk of serious dehydration, electrolyte imbalance, and other potentially serious consequences. If severe diarrhea occurs or you experience an unusual or allergic reaction to Linzess, contact your healthcare provider or visit the nearest hospital emergency room.

  • How to take Linzess

    Your pharmacist will provide you with instructions on how to take Linzess. The typical starting dose for adults with IBS is 290 mcg orally, once daily. Adults with chronic idiopathic constipation (CIC) may start with an initial dose of 145 mcg orally, once daily.

    Linzess should be taken by mouth as directed by your doctor, typically once daily on an empty stomach, at least 30 minutes before your first meal. If you cannot swallow Linzess capsules whole, you can open the capsule and mix the contents with a teaspoon of applesauce or mix the contents into water.

    If you miss a dose of Linzess, skip the missed dose and take the next dose at your regular dosing schedule.

  • What to avoid while taking Linzess

    Linzess has 59 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other prescription drugs, over-the-counter medicines, and other drugs.

    Linzess is not known to interact with alcohol. However, taking Linzess with food may increase GI side effects such as stomach pain, diarrhea, and gas.

Medication alternatives to Linzess

  • Plecanatide (Trulance)

    Prucalopride (Motegrity)

    Zelnorm (tegaserod)

What to know about Linzess

  • How long does it take for Linzess to work?

    Linzess helps treat chronic constipation within 24 hours of taking your first dose. It may take up to two weeks to experience the full effects of Linzess.

  • How long does Linzess stay in your system?

    Linzess typically stays in your system from 24 hours to 72 hours.

  • How much does Linzess cost?

    Depending on your pharmacy, Linzess costs around $552 for thirty 72 mcg mg capsules without insurance. Fortunately, generic brands, such as linaclotide, offer an affordable alternative.

  • What does Linzess do for your stomach?

    Linzess treats certain types of bowel problems by increasing intestinal fluid secretion. This increased intestinal fluid helps accelerate the movement of food through the gut.

  • Which is better: MiraLAX or Linzess?

    Linzess is generally more effective than MiraLAX when taken with water.

3 steps to get your Linzess prescription today

Step 1: Book an appointment

Step 1

Book a Linzess prescription appointment.

Book a same-day appointment from anywhere.

Step 2

Talk to your clinician regarding a Linzess prescription.

Talk to a doctor about your abdominal discomfort symptoms on your smartphone or computer.

Step 3

Pick up your Linzess prescription.

We can send prescriptions to any local pharmacy.

Linzess prescription pricing details

How it works

To get a new or refill on your Linzess prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.