Xenical (Orlistat) Prescriptions Available Online Today

Our doctors are here to help. Xenical (Orlistat) is prescribed for weight loss and weight management. Speak to one of our board-certified doctors to see if Xenical (Orlistat) is right for you.

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Can You Get Xenical (Orlistat) Online?

Yes, licensed medical doctors can prescribe Xenical (Orlistat) online after a medical evaluation.

You can speak with one of our online doctors to learn more about Xenical (Orlistat). Book an online appointment with one of our top doctors using your phone or computer.

During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for Xenical (Orlistat), they can write a prescription and electronically send it to a nearby pharmacy for pickup.

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What Is Xenical (Orlistat)?

Orlistat is a prescription weight loss medication used in conjunction with diet and exercise to meet weight loss goals. The United States Food and Drug Administration (FDA) approved Orlistat capsules, branded as Alli, as an over-the-counter treatment for excess weight in adults in 2007, while the drug had previously been approved in 1999 as the prescription weight loss aid, with the brand name Xenical. Orlistat, Xenical, and Alli are all made up of the exact same chemical. The difference between the prescription and over-the-counter version is just the dosage.

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We can send prescriptions to any local pharmacy or by mail.

Orlistat is prescribed in a pill form and is taken by mouth. Alli is the over-the-counter version of Orlistat and is dosed at 60 mg. Xenical, the prescription version, is dosed at 120 mg and is FDA-approved in people with excess weight as well as weight-related problems like high blood pressure, diabetes, abnormal cholesterol, or heart disease. Both Alli and Orlistat are meant to be used as part of a comprehensive weight-loss plan that includes diet changes and regular physical activity. 

Orlistat works by blocking fat absorption of foods ingested. It does this by blocking activity of the enzyme lipase, which breaks down fats in the intestine, allowing the fat molecules to be absorbed by the body.  

Therefore, Orlistat promotes weight loss by decreasing the amount of dietary fat absorbed in your intestines by about 25%. This fat which is not absorbed is eliminated through bowel movements. 

Because Orlistat helps to reduce the amount of fat your body absorbs, in theory this would mean that you burn off existing fat stores in your body for energy rather than the fat you consume, resulting in weight loss. 

Studies show that taking Orlistat may be able to help reduce your body mass by up to 3% to 5%, which may help reduce the risk of weight-related problems like cardiovascular diseases. Orlistat is associated with small but significant weight loss when compared to diet alone in overweight and obese people. Orlistat may be prescribed for those who struggle with weight loss or maintaining weight loss.

Because Orlistat affects the absorption of fat within your body, some side effects may occur. Most side effects subside over time with the appropriate dose and dietary modifications. Side effects may include:

  • Abdominal pain
  • Oily discharge from the anus
  • Gas with oily anal discharge
  • Oily stools
  • Frequent bowel movements
  • Urgent or hard-to-control bowel movements
  • Headache
  • Back pain
  • Upper respiratory infection

To limit side effects, it is advised that your daily fat should not exceed 30% of your total calorie intake each day. This means no more than 15 grams of fat per meal (3 meals) should be consumed per day.  Because of this, Orlistat may not work well with higher-fat eating plans including keto or paleo diets.

Before taking Orlistat, you should notify your doctor of all of your medical conditions and which prescription medications you take. Some conditions may be negatively impacted by Orlistat. Some interactions may occur if you take medications to treat:

  • Thyroid disease – Orlistat may decrease the serum concentration of thyroid medications
  • Cardiovascular disease or irregular heartbeat – Orlistat may increase or decrease the concentration of heart medications.
  • Seizures – Orlistat may increase the serum concentration of anticonvulsant medications
  • HIV – Orlistat may increase the serum concentration of antiretroviral agents
  • Vitamin deficiencies like vitamin D – Orlistat may further aggravate this condition.

Orlistat interactions may occur if you have underlying conditions. It is important to notify your doctor if you have the following conditions, because Orlistat can make these conditions worse by interfering with the breakdown of fats in the intestine:

If frequent diarrhea results from your use of Orlistat, there is also the potential for dehydration, which can be serious. Prior to taking any over-the-counter medications, always contact your doctor to check in to make sure that the medication is right for you.

Orlistat is available online through a doctor’s prescription as the prescription drug Xenical. You can request Xenical (Orlistat) during a medical evaluation with a licensed doctor.

If you are concerned about excess weight and are looking to discuss a prescription medication to help you reach your weight loss goal, make an appointment to speak with an online medical doctor at PlushCare. Our highly experienced doctors can speak with you online, assess your symptoms and medical concerns, and discuss weight management and prescription options for those who qualify. Book an appointment to speak with a doctor online today.


Telehealth is not appropriate for serious conditions that require immediate attention or emergency care. If you experience any life-threatening issues, call 911 or go to an emergency room immediately.


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