
Rybelsus® prescription available online
Rybelsus® is proven to lower A1C in type 2 diabetes patients. Get a new prescription or refill of Rybelsus® today from a board-certified doctor online.*
About Rybelsus® (semaglutide) prescription medicine
Rybelsus® is known to treat type 2 diabetes. Rybelsus® is available only by prescription. The medication uses the active ingredient semaglutide. It is important to note that Rybelsus® is not available under any generic names or options. It is only possible to find this drug in its brand name.
This medication usually comes in the form of an oral tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.
If you are prescribed Rybelsus®, be sure to complete the entire course of the anti-diabetic drug unless your doctor specifically tells you to stop.
If you don’t complete your prescription, the glucagon-like peptide-1 (GLP-1) agonist may not fully treat your type 2 diabetes. This is generally a long-term treatment solution, and there are precise instructions that you need to follow if you want to see improvements in your diabetes management.
Rybelsus® (semaglutide) prescription uses
There is only one FDA-approved use for Rybelsus®. It is important to note that Rybelsus® is generally not used for off-label purposes due to the specific actions that the drug performs. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.
Type 2 diabetes
The FDA has provided approval for the use of Rybelsus® in patients who have been diagnosed with type 2 . With this said, Rybelsus® is usually not a first-line treatment option for people with this condition. Instead, it may be an excellent alternative to other medications generally considered the first line of defense against type 2 diabetes. If the patient has difficulty controlling their sugar levels with first-line medications such as metformin, a physician may consider adding Rybelsus® as an additional medication to their treatment plan.
Our doctors craft tailored solutions for each patient. While Rybelsus® (semaglutide) stands out as a top-tier choice, we believe in empowering our patients to select the treatment that best aligns with their unique health journey. Our physicians, mindful of availability and individual requirements, may recommend or prescribe a different GLP-1 for type 2 diabetes management. Explore these GLP-1 options below:
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Mounjaro® (tirzepatide): This unique medication has dual GLP-1 and GIP receptor activity. This innovative approach may resonate with patients looking for a holistic strategy for managing their diabetes.
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Ozempic® (semaglutide): Ozempic® remains a standout with its once-weekly injectable format, delivering reliability and efficiency in blood sugar management. Its ability to reduce cardiovascular risk adds another layer of appeal.
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Semaglutide: Due to shortages, compounded semaglutide may be prescribed as an alternative to branded Ozempic® as long as it remains on the FDA drug shortages list. Although compounded semaglutide is not FDA-approved, our pharmacy provider complies with pertinent federal and state laws and FDA regulations.*
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Trulicity® (dulaglutide): Trulicity® also comes with a pre-filled disposable pen for its once-weekly injection, ideal for those who want ease of use without compromising consistent blood sugar control.
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Victoza® (liraglutide): This daily injectable provides a trusted solution for diabetes management.
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Bydureon® (exenatide): Bydureon® has an extended-release formulation, requiring just one weekly injection.
For patients with insulin resistance or a semaglutide allergy, your doctor may suggest alternatives to GLP-1 anti-diabetic medications. Individuals with insulin resistance and difficult-to-control sugars may also receive a different medication as part of their treatment plan, such as metformin or NovoLog (insulin aspart). For patients with a semaglutide allergy, medications such as Jardiance (empagliflozin) or Glucotrol (glipizide) may be considered.
*Compounded semaglutide prescriptions are limited to residents in the following states: AZ, CA, CO, CT, DE, FL, GA, HI, IA, ID, IL, KS, MA, MD, ME, MO, MS, MT, NC, ND, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, TN, TX, UT, VA, VT, WA, WI, WV, Washington D.C., WY.
What are the pros and cons?
Cons
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Must be taken on an empty stomach
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Only for type 2 diabetes
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May have more gastrointestinal side effects when compared to other GLP-1s
Rybelsus® (semaglutide) prescription side effects
The side effects of Rybelsus® are typically mild. Most Rybelsus® side effects are associated with the digestive tract. Rybelsus® has some common side effects. They may include:
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Vomiting
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Pain in the abdomen
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A reduction in appetite
It is common for people to experience nausea, as well as constipation, when they first start the medication. These side effects of Rybelsus® will often reemerge when the patient has a change in the dose they take.
Other side effects of Rybelsus®, which are less common but might be more severe, can consist of a rapid heartbeat, gallbladder problems, and even a severe allergic reaction. Here we look at the more serious side effects of Rybelsus®:
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Thyroid problems: There is a rare risk of problems developing with the Thyroid gland. This gland plays a vital role in metabolism and several other bodily functions. Some reports of Thyroid tumors have been noted among individuals who take Rybelsus®. The manufacturer has also warned about a risk of cancerous tumors on the Thyroid gland. Due to the risk of thyroid cancer, it is recommended not to take Rybelsus® for patients with a personal or family history of thyroid cancer.
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Pancreatitis: Individuals also risk experiencing inflammation in their pancreas while they take Rybelsus®. This condition may lead to severe pain that occurs in the abdomen. The pain will not go away. Some people may vomit while they experience the pain symptoms. This is a potentially life-threatening side effect. If you have symptoms of pancreatitis, it is recommended to seek medical help immediately and go to the nearest emergency room for medical care.
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Hypoglycemia: Due to the reduction in blood glucose and the increase in insulin, some patients may also experience low blood sugar when they use Rybelsus® with other medicines that can also cause low blood sugars, such as insulin or sulfonylureas. In this case, the patient is at risk of severe side effects if there is a significant drop in blood sugar levels. Some signs include dizziness, changes in mood, irritability, weakness, and a headache. Severe weakness, a very fast heartbeat, and anxiety can also happen. It is possible to experience vision problems related to low blood sugar, too. These vision problems related to hypoglycemia usually present themselves as blurred vision.
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Kidney failure: There is also a slight risk of kidney failure when using Rybelsus® daily. The risk of kidney failure is much higher among individuals who already have existing problems with their kidneys. These complications may cause dehydration, vomiting, nausea, and diarrhea.
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Gallbladder side effects: There are also some rare cases where Rybelsus® causes problems with the gallbladder. Upper abdomen pain, stool that has a clay color, a fever, and signs of jaundice can signal the presence of gallbladder issues.
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Allergic reaction: There is also a risk of an allergic reaction when a patient uses Rybelsus®. A severe allergic reaction can sometimes be fatal if the patient does not receive treatment promptly. Swelling in the mouth, such as the tongue, lips, and face, are signs of allergic reactions. An allergic reaction can also make breathing difficult, cause a rapid heartbeat, and make the person feel dizzy. Skin rashes are also common when an allergic reaction occurs. Individuals should be aware of allergic reaction symptoms when using these prescription drugs. Severe allergic reactions should be reported to the emergency department.
You should call your doctor if you notice any of these side effects or develop other new or concerning symptoms. Use of Rybelsus® in young children under age 18 is not advised as it is not FDA-approved or studied in pediatric populations.
How to take Rybelsus® (semaglutide) prescription medicine
Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.
Rybelsus® can come in different forms and doses, so follow the specific instructions on your prescription. It is typically prescribed once a day.
The usage instructions for Rybelsus® are precise. It is crucial for the patient to carefully follow these instructions to ensure the medication works effectively and as expected. Taking the medication with only a small amount of water is usually advised.
General instructions may include taking the medication early in the morning to ensure the medication works throughout the day. The patient should also wait a certain amount of time before they consume breakfast after they use the drug - but it is essential not to skip breakfast. If you have trouble swallowing the prescription medicine, talk to your doctor about these oral medicines. Crushing or chewing the prescription medication is not advised if you have difficulty swallowing it.
What to avoid while taking Rybelsus® (semaglutide)
It is essential to be careful with beta-blocker drugs when taking Rybelsus®. Combining Rybelsus® with certain beta-blockers may make it harder to identify a sudden fall in your blood glucose levels.
This is because the beta-blockers may prevent some of the symptoms, such as a fast heartbeat, that happens when you have hypoglycemia. Failure to recognize the early signs can lead to a more severe drop in blood sugar levels. Be on the lookout for sweating, excessive hunger, and dizziness in these cases. These are also signs of low blood sugar.
Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Rybelsus®.
Some research shows that regular alcohol consumption may cause changes in blood glucose levels. When the liver needs to metabolize alcohol, it may not work fast enough to process sugar. This can lead to a poor release of glucose into the blood, which can cause a drop in blood glucose levels. Thus, if you do not want to give up drinking, then make sure you limit your consumption of alcohol while you are taking Rybelsus®.
You must also check any supplements you use when prescribed a daily dose of Rybelsus®. Some herbal and dietary supplements may cause a reduction in blood glucose levels.
Combined with Rybelsus®, this can significantly increase the risk of experiencing hypoglycemia. This also accounts for over-the-counter medicines. Some over-the-counter medications may interact with the drug or affect your blood sugar levels. This may increase the risk of low blood sugar or other related complications.
If you have problems with your thyroid C cell function or previously had thyroid cancer, tell your doctor before you take Rybelsus®. This is due to the risk of thyroid cancer associated with this medication. The doctor may monitor closely for thyroid tumors or choose to use a different medicine to manage your blood sugar.
Talk to your doctor about other prescription drugs that you use. When your doctor understands the prescription and over-the-counter medications you use, it is easier for them to check for drug interactions.
Rybelsus® prescription FAQs
How much does Rybelsus® cost?
In some cases, the patient requires a more potent dose after this adjustment. Each quantity has its associated price. In addition to dosage, you also have to focus on where you get your prescription. Only some pharmacies may offer the medication at the same price. Online prescription services may also differ in terms of cost for Rybelsus®.
How can I refill my Rybelsus® prescription?
What happens if you take Rybelsus® after eating?
The ingredients you add to your prepared meals are unlikely to interact with Rybelsus®. With this said, taking Rybelsus® only a short distance from a meal is generally advised. This is because food may reduce the amount of the active chemicals your body absorbs. In turn, this can adversely affect the efficacy of the drug. Instead, wait at least 30 minutes after you consume Rybelsus® before you have a meal. This can help to improve the effectiveness that the medication provides.
What time of day should Rybelsus® be taken?
How long does it take to get used to Rybelsus®?
Who should not take Rybelsus®?
What happens if I miss a dose of Rybelsus®?
What happens if I take too much Rybelsus®?
If you digest too much of these pills, then the Rybelsus® can cause a significant drop in your blood glucose levels. This can lead to severe hypoglycemia (low blood sugar levels), which could cause you to pass out and lose consciousness. Other side effects that might occur include nausea, vomiting, constipation, and pancreatitis. If you accidentally take too much of this medication, please contact a medical professional right away or call your local poison control center.
3 simple steps to request your Rybelsus® prescription today

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Rybelsus® prescription pricing details
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Rybelsus® prescription resources
Sources:
PlushCare is dedicated to providing you with accurate and trustworthy health information.
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Rybelsus. "What to Expect with Rybelsus." Novo Nordisk, Accessed Oct. 5, 2023. https://www.rybelsus.com/taking-rybelsus/what-to-expect-with-rybelsus.html.
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"Rybelsus Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing." WebMD, Accessed Oct. 5, 2023. https://www.webmd.com/drugs/2/drug-178019/rybelsus-oral/details.
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"Rybelsus (Oral Route) Side Effects." Healthline, Accessed Oct. 5, 2023. https://www.healthline.com/health/drugs/rybelsus.
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