GLP-1 medications available online

GLP-1 drugs can significantly support weight loss and treat symptoms of type 2 diabetes by mimicking a hormone your body naturally uses to regulate your blood sugar and appetite. Get a new prescription or refill for GLP-1 medications from a board-certified primary care doctor today.*

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Reduces over-eating and controls appetite

Clinically proven and effective GLP-1 RXs

Enhance the body's sugar response

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy.

How do GLP-1 drugs work, and what do they treat?

GLP-1 drugs are known as GLP-1 receptor agonists. They function similarly to a natural hormone produced by your body called GLP-1, short for glucagon-like peptide-1, which regulates blood sugar and hunger signals. GLP-1 receptors are found in the brain and the pancreas.

These medications can help promote long-lasting weight loss and treat symptoms of type 2 diabetes.

Benefits of GLP-1 medications:

GLP-1s work together with your body, ensuring that your weight loss journey aligns with your needs. This targets the root causes of weight gain for sustainable, long-lasting results.

  • Medically-backed: GLP-1s use proven science to help you avoid overeating to lose weight.

  • Control your hunger: GLP-1s can make you feel full faster and longer while preventing blood sugar spikes.

  • Easy dosing: Inject GLP-1s with easy-to-use single-dose or multi-dose pens.

Most GLP-1s will take two to four weeks to start improving blood sugar. It can take eight weeks or longer to feel the full effects of GLP-1 drugs, including weight loss effects.

It is important to note that weight loss results can vary depending on the type of drug you take and your prescribed dose. Always consult your physician for personalized medical advice.

What types of GLP-1 medications are available?

We prescribe many effective GLP-1s to treat obesity and/or type 2 diabetes as part of a medically guided treatment plan. Our top-rated doctors will review your health goals and medical history to create a personalized treatment strategy, including determining which GLP-1 would work best for you.*

Qualifying patients with a BMI of 27 and at least one weight-related condition or a BMI of over 30 may be eligible for GLP-1s. The evaluation will include completing any necessary lab work and reviewing the results with your doctor.

  • FDA-approved GLP-1 medications for weight loss:

    • Patients taking Wegovy had an average weight loss of 14.9% after 68 weeks (1)

    • Patients who took Saxenda had between 5 and 10% weight loss compared with placebo after 56 weeks (2)

  • FDA-approved GLP-1 medications for type 2 diabetes:

    Several other GLP-1s are approved to treat type 2 diabetes and can also result in significant weight loss.

    It is important to note that most GLP-1s need prior authorization for your insurance to cover the cost. To find out whether your medication needs prior authorization, call your insurance company.

    Please note that prior authorization for GLP-1s that are FDA-approved for type 2 diabetes is usually to verify that the prescription is being written for type 2 diabetes. Many insurances do not cover type 2 diabetes GLP-1s, such as Ozempic or Mounjaro, for weight loss purposes.

    If your medication does need prior authorization, there's no need to worry. Your PlushCare physician and care team will contact your insurer on your behalf and handle the process of getting prior authorization for your medication. If you don't have health insurance or get denied prior authorization, you can still buy the medication at the total out-of-pocket price. However, please note that as there are no generic versions of these medications, the cost without insurance can be roughly ~$1000 per month. Read more about the process for weight management appointments, including further details about labs and prior authorization.

    *Prescriptions are based on a complete evaluation and diagnosis, including lab work, if required, to determine medical necessity. Not all FDA-approved medications may be available based on your location.

GLP-1 medication side effects and risks

Most GLP-1 side effects are associated with mild abdominal discomfort. Common side effects may include:

  • Nausea

  • Vomiting

  • Diarrhea

  • Lower appetite

  • Early feelings of fullness

GLP-1 drugs for weight management and blood sugar control may lead to low blood sugar levels (hypoglycemia). For this reason, it is essential to monitor your blood sugar levels.

GLP-1 receptor agonists can have several drug interactions, so tell your doctor about any medications, including over-the-counter drugs and supplements, before starting these medications.

GLP-1 medication FAQs

  • Which labs are required to get GLP-1 medications?

    Your doctor will order labs for you before prescribing GLP-1 medications. These labs include an obesity lab panel, which measures CBC (blood count), CMP (metabolic function), lipids (cholesterol levels), A1C (diabetes), TSH (thyroid function), and insulin. Your doctor will then review the lab results with you to see if you would benefit from treatment with GLP-1s.

  • Do I need prior authorization for my insurance to cover the cost of GLP-1s?

    As most GLP-1s require prior authorization for insurance coverage, it is likely you will need it.

    Most GLP-1a weight loss and type diabetes medications require a prior authorization (PA) from the insurance provider:

    • FDA-approved weight loss medications: Contrave®, Saxenda® (liraglutide), Wegovy® (semaglutide) Zepbound™ (tirzepatide) 

    • FDA-approved Diabetes medications: Rybelsis®, Victoza® (liraglutide), Ozempic® (semaglutide), or Mounjaro® (tirzepatide) 

    •  If your insurance company says that they cover FDA approved diabetes medications , it suggests coverage for patients with type 2 diabetes. Insurance companies typically do not cover OFF LABEL prescribing of FDA approved for type 2 diabetes for weight loss without a type 2 diabetes diagnosis. It is encouraged to discuss with your doctor the possibility of prescribing an equivalent  and/or similar medication approved for weight loss by the FDA. 

      If you’ve been prescribed an injectable medication for weight loss or type 2 diabetes, our team will automatically start compiling the necessary information. This usually takes 3-7 business days but can vary. If you’ve been prescribed a different type of medication and your pharmacy has told you a PA is needed, you can let us know by calling 1-888-729-0438 or by emailing [email protected]. You may be asked to fill out a short intake form with information about your insurance and prescription history. 

      Once your PA is submitted, you’ll receive an email titled “PRIOR AUTH SUBMISSION”. Your insurance will now review the documentation provided and issue a determination. Processing times vary, but the average is 7-14 days. We’ll notify you once we receive an outcome. If you have any questions during this time, you can reach the Prior Authorizations team directly by responding to the message titled “PRIOR AUTH SUBMISSION” or contact your pharmacy benefit plan directly. Please make sure you call your pharmacy benefit manager (PBM) as they will handle the prior authorization for your prescription and not your medical insurance network. The contact information for your PBM should be on your insurance card but may be on a separate card- common PBMs are ExpressScripts, CVS Caremark, and OptumRx. 

      If you have contacted your PBM and they do not have your prior authorization on file, even though you received communication from us confirming its submission please give us a call at 1-888-729-0438. 

  • What if my prior authorization for my GLP-1 gets denied?

    If your prior authorization is denied, the cost of your GLP-1 will not be covered by your insurance, it is important to understand the denial reason.  Common denial reasons are plan exclusion for weight loss medications, non-formulary for your medication, or need for prior diet and exercise program.  You can discuss the reason for denial at your follow-up appointment with your doctor so they can help you discuss alternatives. Some alternatives include paying cash for medications such as Contrave® or Compounded Semaglutide or Tirzepatide (in certain states).  Submitting an appeal rarely changes the outcome unless important information was not included in your original PA.

  • How do you take GLP-1s?

    Most GLP-1s are injectable medications taken using a pre-filled pen, making it easy to inject yourself. Just like you would inject insulin, you inject GLP-1s into the fat layer, just under the skin. The most common injection sites are the lower abdomen or the front thighs. Rybelsus is an oral GLP-1 medication. It is taken once daily as a pill on an empty stomach, with no more than half a cup of water. Always consult your doctor for personalized medical advice. 

  • What should I know about the GLP-1 shortages?

    Currently, there is a high demand for weight loss medications in the U.S., causing a shortage of Saxenda and Wegovy, the only two GLP-1s currently approved for weight loss (as of September 2023). The Saxenda shortage is expected to last at least until the end of 2023. The Wegovy shortage affects starter doses and is expected to last into 2024. It is not possible to start taking Wegovy at a higher dose. If you are taking Wegovy or Saxenda and would like to continue the medication, we recommend calling local or mail-order pharmacies to see if they have your dose available.

    Read more about the Wegovy shortage and alternative medication options.

  • Is there a way to save on the cost of GLP-1s if I’m paying the cash price?

    As a PlushCare member, you can use our in-app Rx price finder to find the pharmacy nearest you with the lowest cost for your medication. With our Prescription Discount Card, available in-app, patients have saved from 7-20% on GLP-1 medications.

    If your insurance does not cover these medications, or you are planning on paying out of pocket and need help covering the cost of your medication, it's worth also checking the manufacturer's website for coupons that may save you money on  Ozempic, Wegovy, or Mounjaro. It is important to acknowledge that these companies have eligibility and restrictions requirements for these coupons, and reviewing the criteria on their website is recommended to see if you qualify.*

    • For example, the Wegovy coupon on Novo Nordisk’s site may help you save up to $500 off of the full price of ~$1500 for a month's supply. 

    • For patients with type 2 diabetes, the Ozempic coupon on Novo Nordisk’s site may help you save up to $150 per month off the full price of ~$1000 for a month’s supply

    • For patients with type 2 diabetes, there is a coupon on Eli Lilly’s website for Mounjaro to help cover the out-of-pocket cost of roughly ~$1100 for a month’s supply. Keep in mind that your pharmacy will likely need to see proof of type 2 diabetes for the savings coupons from Eli Lilly or Novo Nordisk for Mounjaro or Ozempic through a diagnosis code associated with the medication order before they can apply the coupon. Prescriptions cannot be written for a diagnosis of type 2 diabetes if a patient does not have a confirmed diagnosis of type 2 diabetes.

    *Please note that the manufacturer’s coupons cannot be used in combination with the savings from our Prescription Discount Card. You can check with your pharmacy to determine which card or coupon will offer you the most savings.

  • Who shouldn’t take GLP-1 agonists?

    Talk to your doctor before taking GLP-1 medications if you have any of the following conditions:

    • A personal or family history of medullary thyroid cancer or acute pancreatitis

    • Type 1 diabetes mellitus

    • Pregnant, planning to become pregnant in the next 3 months, or nursing

    • Delivered a baby within the past 6 months

    • Ongoing heavy alcohol use

    • Active eating disorder, anorexia, or purging.

    • History of suicidal thinking

    • Non-medullary thyroid cancer

    • A family history of multiple endocrine neoplasia type 2

  • Will I gain the weight back when I stop GLP-1s?

    Because GLP-1s target the root causes of weight gain, many patients experience sustained weight loss after stopping the medication. However, GLP-1s work best with a healthy diet and exercise plan. Individuals have a higher risk of gaining the weight back if they do not keep up with the healthy lifestyle changes they made.

How to get GLP-1 medications online

Step 1: Book an appointment

Step 1

Book an appointment to discuss GLP-1 agonists.

During your first visit, your PlushCare doctor will review your medical history and health goals.

Step 2

Talk to your doctor online about your weight management or type 2 diabetes concerns.

Visit with a doctor on your smartphone or computer. Often, lab work is required, and they’ll send an order to your preferred lab. Once your results are available, your doctor will review them with you at the second visit and discuss treatment options.

Step 3

Pick up your GLP-1 medication, if prescribed.

Prescriptions are provided based on eligibility and safety. Our physicians may prescribe medications, help you set diet and exercise goals, and monitor your weight loss progress.

GLP-1 medication pricing details

How pricing works

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

*We'll provide a full refund if we cannot treat you. Please note that any medication or lab work costs are not included.


PlushCare is dedicated to providing you with accurate and trustworthy health information.

  1. The New England Journal of Medicine. Once-Weekly Semaglutide in Adults with Overweight or Obesity. Accessed on July 28, 2023 at

  2. NovoMedlink. Significant Weight Loss with Saxenda®. Accessed on July 28, 2023 at

  3. Cleveland Clinic. GLP-1 Agonists. Accessed on July 28, 2023.

  4. Mayo Clinic. GLP-1 agonists: Diabetes drugs and weight loss. Accessed on July 28, 2023.

  5. National Library of Medicine. Glucagon-like Peptide-1 Receptor Agonists. Accessed on July 28, 2023.

PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.