Cymbalta (duloxetine) online prescription available

If you are living with depression, anxiety, or nerve pain, the medication Cymbalta (duloxetine) can help. Get a same-day prescription or refill of Cymbalta today with a caring, board-certified primary care doctor online.*

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*Warning: Certain antidepressants to treat the major depressive disorder (MDD) in adolescents may increase the risk of suicidal ideations and behaviors. While taking antidepressants, mental health can change in unexpected ways. You should call a doctor right away if you experience any suicidal thoughts. Always talk to a doctor about the risks and benefits of taking antidepressant medication before beginning treatment. *Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how to save up to 80% with our prescription discount card. Not all mental health visits are best suited for primary care physicians or telehealth. To get you the best possible care, our doctors may recommend referrals to psychiatry or other in-person services and will help guide you to those with referrals and resources.  

About Cymbalta (duloxetine) medication 

Cymbalta (duloxetine) is an antidepressant medication that helps treat anxiety and depression. As a serotonin and norepinephrine reuptake inhibitor (SNRI) medication, Cymbalta helps increase levels of those neurotransmitters, improving imbalances that contribute to feelings of depression and anxiety. 

Cymbalta is available only by prescription. It is also available in a generic formulation as duloxetine. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed. 

Cymbalta uses

There are several FDA-approved uses for Cymbalta, but your healthcare provider may also prescribe it off-label to treat other medical conditions. Off-label means it’s been studied as safe and effective for those treatments, but not formally studied by the FDA (Food and Drug Administration). 

Your PlushCare doctor may prescribe Cymbalta for the following reasons or other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Depression and anxiety

    Cymbalta is FDA-approved to treat the major depressive disorder (MDD) and generalized anxiety disorder (GAD). Like other norepinephrine reuptake inhibitors, Cymbalta helps increase serotonin and norepinephrine availability in the brain to regulate mood.

  • Neuropathic pain (nerve pain)

    Cymbalta is FDA-approved to help regulate neuropathic pain, including chronic musculoskeletal pain caused by diabetic neuropathy. Cymbalta regulates the activity of neurotransmitters in the central nervous system, which helps reduce pain perception and improve mood.

  • Fibromyalgia and arthritis

    Cymbalta is FDA-approved to treat fibromyalgia and chronic musculoskeletal pain, including chronic lower back pain and osteoarthritis.

Cymbalta side effects

  • The side effects associated with taking Cymbalta are typically mild. Individuals taking Cymbalta report a variety of side effects, and side effects may vary from patient to patient. 

    The side effects of Cymbalta include:

    • Nausea

    • Headache

    • Dry mouth

    • Tiredness and fatigue

    • Trouble sleeping

    • Constipation

    • Dizziness

    Other side effects, which are less common but might be more severe, could include:

    • Allergic reaction

    • Serotonin syndrome

    • Suicidal thoughts

    • Vision changes

    • Liver problems

    Tell your doctor if you notice any adverse effects or if you develop any other new or worsening symptoms. Cymbalta is not recommended in children under 7, as it can increase the frequency of suicidal thoughts.

How to take Cymbalta

Your pharmacist will provide instructions on how to take your Cymbalta prescription. Make sure to read your prescription label and follow the instructions. Call your doctor or if you have any questions.

Cymbalta capsules are taken 1–2 times daily with or without food. While the typical initial dose for patients with mental illness usually ranges from 40 mg to 60 mg daily, the initial dose for neuropathic pain often starts at 60 mg.

Cymbalta is a delayed-onset medication. As a result, you may not notice any symptom improvements until after 4 weeks of consistent use.

You should not stop taking Cymbalta unless you develop serious side effects. If you decide to stop Cymbalta treatment, your doctor will help you gradually reduce your dosage to avoid withdrawal symptoms. 

What to avoid while taking Cymbalta

Cymbalta has several drug interactions. Don't stop taking your medications without talking to your doctor or pharmacist. That includes other medications, supplements, and other drugs.

Some possible drug interactions with Cymbalta include:

If you drink alcohol, talk to your doctor before starting Cymbalta treatment. When taking Cymbalta, alcohol can increase your risk for liver problems, such as liver failure. 

Medication alternatives to Cymbalta

If your healthcare provider prefers to prescribe another medication, they may suggest another SNRI or antidepressant medication to treat your medical condition. Some common doctor-recommended alternatives to Cymbalta include:

Cymbalta prescription FAQs

  • How much does Cymbalta cost?

    Depending on your pharmacy, brand name Cymbalta capsule delayed-release prescriptions cost approximately $296 for a supply of thirty 30 mg capsules without insurance. Fortunately, generic brands, such as duloxetine, offer an affordable alternative.

  • How can I refill my Cymbalta prescription?

    To refill your Cymbalta prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your symptoms, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Cymbalta?

    You should avoid taking Cymbalta if you have any of the following medical conditions: 

    • Heart problems, including high blood pressure

    • Pregnancy 

    • Eye problems, such as glaucoma

    • Kidney or liver disease

    • Bleeding problems

    • Substance use disorder

    • Low sodium levels 

  • What happens if I miss a dose of Cymbalta?

    If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and take the next dose at the regular time. Avoid taking two doses of Cymbalta to make up for a missed dose.

  • What happens if I take too much Cymbalta?

    If you overdose on Cymbalta, call your doctor or seek medical attention immediately. You may require emergency medical care. 

  • Are Cymbalta and Xanax the same thing?

    No, Cymbalta and Xanax are different medications.

    Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, and chronic pain. Meanwhile, Xanax (alprazolam) is a benzodiazepine used to treat anxiety and panic disorders. Unlike Xanax, Cymbalta is not a controlled substance, so it can be prescribed online.

3 simple steps to request your Cymbalta prescription today

Step 1

Book a Cymbalta prescription request appointment.

You can book a same-day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Cymbalta prescription.

You can visit a doctor on your smartphone or computer.

Step 3

Pick up your Cymbalta prescription, if provided by your doctor.

We can send prescriptions to any local pharmacy.

Cymbalta prescription pricing details

How pricing works

To get a new or refill on your Cymbalta prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.