We accept these insurance plans and many more!
Most patients with in-network insurance pay $30 or less. Paying without insurance? New patient visits are $129, and follow-ups are only $99 for members.
Don’t see your provider listed? Email [email protected] or call (888) 564-4454 to talk to a PlushCare specialist.
3 simple steps to request your Cymbalta prescription today

Step 1
Book a Cymbalta prescription request appointment.
You can book a same-day appointment from anywhere.

Step 2
Talk to your medical provider regarding your Cymbalta prescription.
You can visit a doctor on your smartphone or computer.

Step 3
Pick up your Cymbalta prescription.
We can send prescriptions to any local pharmacy.
Cymbalta prescription pricing details
How pricing works
To get a new or refill on your Cymbalta prescription, join our monthly membership and get discounted visits.
Paying with insurance
Membership
$14.99/month
First month free
First visit
Copay
For all visits
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price with insurance
Often the same as an office visit. Most patients with in-network insurance pay $30 or less!
We accept these insurance plans and many more:
Paying without insurance
Membership
$14.99/month
First month free
First visit
$129
Repeats only $99
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price without insurance
Initial visits are $129 and follow-ups are only $99 for active members.
If we're unable to treat you, we'll provide a full refund.
Cymbalta prescription FAQs
How much does Cymbalta cost?
Depending on your pharmacy, Cymbalta capsule delayed-release prescriptions cost approximately $296 for a supply of thirty 30 mg capsules without insurance. Fortunately, generic brands, such as duloxetine, offer an affordable alternative.
How can I refill my Cymbalta prescription?
To refill your Cymbalta prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your symptoms, your doctor can send an electronic prescription to your local pharmacy.
Who should not take Cymbalta?
You should avoid taking Cymbalta if you have any of the following medical conditions:
Heart problems, including high blood pressure
Pregnancy
Eye problems, such as glaucoma
Kidney or liver disease
Bleeding problems
Substance use disorder
Low sodium levels
What happens if I miss a dose of Cymbalta?
If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and take the next dose at the regular time. Avoid taking two doses of Cymbalta to make up for a missed dose.
What happens if I take too much Cymbalta?
If you overdose on Cymbalta, call your doctor or seek medical attention immediately. You may require emergency medical care.
Are Cymbalta and Xanax the same thing?
No, Cymbalta and Xanax are different medications.
Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, and chronic pain. Meanwhile, Xanax (alprazolam) is a benzodiazepine used to treat anxiety and panic disorders. Unlike Xanax, Cymbalta is not a controlled substance, so it can be prescribed online.
About Cymbalta (duloxetine)
Cymbalta (duloxetine) is an antidepressant medication that affects the brain. As a serotonin and norepinephrine reuptake inhibitor (SNRI), Cymbalta helps re-establish the balance of hormones in the brain to regulate neurotransmitter imbalances due to depression and anxiety.
Cymbalta is available only by prescription. It is also available in a generic formulation under duloxetine. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.
If you're prescribed Cymbalta, complete the entire course of the SNRI unless your doctor specifically tells you to stop. If you don’t complete your prescription, the SNRI may not fully treat your depression, anxiety, or nerve pain.
Cymbalta uses
There are several FDA-approved uses for Cymbalta, but your healthcare provider may also prescribe it off-label to treat other medical conditions.
Your PlushCare doctor may prescribe Cymbalta for the following reasons or other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.
Depression and anxiety
Cymbalta is FDA-approved to treat the major depressive disorder (MDD) and generalized anxiety disorder (GAD). Like other norepinephrine reuptake inhibitors, Cymbalta helps increase serotonin and norepinephrine availability in the brain to regulate mood.
Neuropathic pain (nerve pain)
Cymbalta is FDA-approved to help regulate neuropathic pain, including chronic musculoskeletal pain caused by diabetic neuropathy. Cymbalta regulates the activity of neurotransmitters in the central nervous system, which helps reduce pain perception and improve mood.
Fibromyalgia and arthritis
Cymbalta is FDA-approved to treat fibromyalgia and chronic musculoskeletal pain, including chronic lower back pain and osteoarthritis.
Cymbalta side effects
The side effects associated with taking Cymbalta are typically mild. Individuals taking Cymbalta report a variety of side effects, and side effects may vary from patient to patient.
The side effects of Cymbalta include:Nausea
Headache
Dry mouth
Tiredness and fatigue
Trouble sleeping
Constipation
Dizziness
Other side effects, which are less common but might be more severe, could include:Allergic reaction
Serotonin syndrome
Suicidal thoughts
Vision changes
Liver problems
Tell your doctor if you notice any adverse effects or if you develop any other new or worsening symptoms. Cymbalta is not recommended in pediatric patients, as it can increase the frequency of suicidal thoughts.
How to take Cymbalta
Your pharmacist will provide instructions on how to take your Cymbalta prescription. Make sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.
Cymbalta capsules are taken 1–2 times daily with or without food. While the typical initial dose for patients with mental illness usually ranges from 40 mg to 60 mg daily, the initial dose for neuropathic pain often starts at 60 mg.
Cymbalta is a delayed-onset medication. As a result, you may not notice any symptom improvements until after 4 weeks of consistent use.
You should not stop taking Cymbalta unless you develop serious side effects. If you decide to stop Cymbalta treatment, your doctor will help you gradually reduce your dosage to avoid withdrawal symptoms.
What to avoid while taking Cymbalta
Cymbalta has several drug interactions. Don't stop taking your medications without talking to your doctor or pharmacist. That includes other medications, supplements, and other drugs.
Some possible drug interactions with Cymbalta include:
Lisinopril
Lyrica (pregabalin)
Omeprazole
Tramadol
If you drink alcohol, talk to your doctor before starting Cymbalta treatment. When taking Cymbalta, alcohol can increase your risk for liver problems, such as liver failure.
Medication alternatives to Cymbalta
If your healthcare provider prefers to prescribe another medication, they may suggest another SNRI or antidepressant medication to treat your medical condition. Some common doctor-recommended alternatives to Cymbalta include:
Anxiety and depression
Neuropathic pain
AmitriptylineTramadol
Fibromyalgia
Osteoarthritis