ED medication prescriptions available online today

Learn how erectile dysfunction medication can help with a consultation from one of our board-certified doctors online. Get a new prescription for ED medication or refill an existing prescription today.

Book an appointment
Book an appointment

Learn how erectile dysfunction medication can help with a consultation from one of our board-certified doctors online. Get a new prescription for ED medication or refill an existing prescription today.

Medication services available for adults and kids (3+)

Top quality, board-certified doctors

Insurance accepted, but not required

Prescriptions sent to your local pharmacy*

*Prescriptions provided at doctor’s discretion

We accept these insurance plans and many more!

Most patients with in-network insurance pay $30 or less. Otherwise, new patient visits are $129, and follow-ups are only $69 for members.

Don’t see your provider listed? Email [email protected]  or call  (888) 564-4454  to talk to a PlushCare specialist.

3 simple steps to getting ED medication online 

Step 1

Book an appointment to discuss ED medication.

Book a same day appointment from anywhere.

Step 2

Talk to your doctor online.

See a doctor on your smartphone or computer.

Step 3

Pick up your ED medication prescription from your online doctor.

We can send ED medication to any local pharmacy.

ED medication pricing details

How pricing works

To get ED medication online, join our monthly membership and get discounted visits.

Paying with insurance



First month free

First visit


For all visits

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free

First visit


Repeats only $69

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129 and follow-ups are only $69 for active members.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

About erectile dysfunction medication

ED medications are medications designed to reverse erectile dysfunction (ED) by improving blood flow. They’re often prescribed to help treat erectile dysfunction, but they’re used for other conditions as well. There are 4 types of prescription ED medication. 

What ED medication treats

The most common condition treated with ED medication is erectile dysfunction. The drugs are designed to enhance the effects of nitric oxide, a naturally occurring chemical in the body.

Nitric oxide dilates or widens blood vessels and relaxes penile muscles to allow more blood to flow to chambers in the penis and produce an erection.

Other conditions are also treated with erectile dysfunction medications. Pulmonary hypertension, for example, can be treated with sildenafil, a common ED medication. Below, you can see how ED pills help treat pulmonary arterial hypertension and several other health problems.

  • Pulmonary hypertension

    For the treatment of pulmonary hypertension, a condition that causes high blood pressure in the lungs, sildenafil relaxes blood vessels and thereby lowers blood pressure. As a result, it becomes easier for the heart to pump blood to the rest of the body.

  • Benign prostatic hyperplasia

    Benign prostatic hyperplasia (BPH), or enlarged prostate, is a condition wherein the prostate gland and the surrounding tissue expands. While the enlargement of the prostate is noncancerous, men experience lower urinary tract symptoms that affect their quality of life.

    One of the off-label uses of ED drugs is the management of urinary symptoms associated with BPH. At the same time, these medications can also improve erectile function in men with an enlarged prostate. The mechanism of action is likely vasodilating effect of nitric oxide.

  • Ureteral stones

    Ureteral stones are kidney stones in one of the ureters that connect the bladder to the kidney. This mineral mass may not cause symptoms, but it can cause a great deal of pain when it starts to move or pass.

    Erectile dysfunction medications may help pass ureteral stones by relaxing the ureter muscles. That way, the ureter widens and is able to pass the stone more easily.

  • Female sexual arousal disorder

    Female sexual arousal disorder happens when a woman’s body doesn’t respond to sexual stimulation. A woman with this disorder has little to no interest in sexual intercourse and doesn’t respond subjectively or physically to sexual stimulation.

    The use of ED drugs could lead to smooth-muscle relaxation in clitoral tissue, which is why they could be beneficial for the management of female sexual arousal disorder.

Types of ED medication available online

The 4 types of ED medication medications are called sildenafil, vardenafil, tadalafil, and avanafil.

  • Sildenafil ED medication

    Sildenafil is most often used to treat erectile dysfunction, a common male sexual dysfunction. These drugs belong to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Their main function is to prevent the PDE5 enzyme from working too much.

    One of the areas where this enzyme function is the penis. For the treatment of erectile dysfunction, it’s best to take sildenafil about an hour before sexual intercourse, but it is also okay to take it anywhere from four hours to 30 minutes before sexual activity. It is most effective when taken on an empty stomach. Sildenafil works for four to five hours after ingestion.

    This ED drug issometimes taken with other medications used to to treat erectile difficulties. A good example is a combination of sildenafil and doxazosin for the management of non-organic ED. It may also be used with medications such as tamsulosin to manage BPH symptoms, and combined with drugs such as dapoxetine to treat premature ejaculation. Since sildenafil may interact with these medications, you should never combine them on your own.

    A healthcare provider is the one who recommends safe dosage to take. Sometimes combining them is the best option for a patient.

    ED medication you can get online:

  • Vardenafil ED medication

    Vardenafil is often used to treat male sexual problems such as impotence or erectile dysfunction. It is a powerful and highly selective PDE5 inhibitor. It increases blood flow to produce an erection, but not without physical activity such as that taking place during sexual intercourse.

    Like sildenafil, it is most effective when taken an hour before sexual intercourse and it can be taken with or without food.

    Examples of vardenafil include:

  • Tadalafil ED medication

    Tadalafil is used to treat erectile problems such as ED, but also for symptoms of enlarged prostate. It belongs to a class of PDE5 inhibitors drugs. Compared to other PDE5 inhibitors, tadalafil has a significantly larger timeframe of effectiveness.

    For instance, sildenafil can work for a few hours after the medication is taken, but tadalafil can be effective for up to 36 hours after a single dose. Tadalafil can be taken with or without food one to two hours before sex.

    Examples of tadalafil include:

  • Avanafil ED medication

    Avanafil is often used to treat problems achieving and maintaining erection strong enough for satisfactory intercourse. It belongs to the same class of medications are the abovementioned drugs i.e. avanafil is a PDE5 inhibitor. The effects of this drug last for up to six hours.

    Examples of avanafil include:

How ED medications work

Erectile dysfunction medications function by increasing blood flow to the penile area. More precisely, PDE5 inhibitors (the only class of oral medications for ED approved in the US) work by protecting a chemical called cyclic guanosine monophosphate (cGMP).

The main function of cGMP is to encourage erection by holding blood in the penile tissue during sexual stimulation. In terms of structure, PDE5 inhibitors are similar to cGMP. At the same time, these drugs inhibit the PDE5 enzyme in penile tissues and blood vessels to enhance the effects of nitric oxide and promote blood flow to the penile area.

More precisely, blood fills corpora cavernosa, two tubes of spongy tissue. Once filled with blood, these tissues swell, thus making the penis larger and stiffer. Then, veins narrow to trap the blood and maintain the erection.

Side effects of ED medication

When taken as prescribed, ED medications are generally well tolerated. However, they can still cause some side effects.

  • The more common side effects of ED medication include:

    • Headache

    • Flushing

    • Stuffy or runny nose

    • Back pain/body aches and pain

    • Indigestion

    • Visual changes e.g. blurred vision, sensitivity to light, blue tinge to vision

    • Upset stomach

    • Diarrhea

    • Rash

    • Dizziness

    In rare cases, ED medication may cause serious side effects. These can include:

    • Hearing loss

    • Vision loss

    • Priapism (persistent erection that doesn’t go away on its own)

ED medication risks

ED medications are generally safe, but there are some risks if you have other medical conditions or take certain medications.

  • Before you take a prescribed ED medication, be sure to tell your doctor if you have any of the following conditions or issues:

    • High risk of heart attack and stroke

    • History of congestive heart failure, a common cardiovascular disease

    • Unstable angina or chest pain

    • Uncontrolled high blood pressure

    • Low blood pressure

    • Arrhythmia

    • Blood vessel problems e.g., aortic stenosis

    • Retinal disorders

    • Hyperlipidemia (high fats in the blood)

    • History of stomach ulcers

    • Severe kidney or liver disease

    • Sickle-cell anemia

  • ED medication drug interactions 

    When you begin a new medication, make sure to tell your doctor about any other medications, supplements, or herbs you’re taking. Some medications that might interact with ED medication include:

    • Blood thinners or anticoagulation medications such as warfarin and enoxaparin

    • Medicines called alpha-blockers, including doxazosin and prazosin

    • HIV protease inhibitors and other drugs for the treatment of HIV infection

    • Medicines called nitrates i.e. vasodilators treat angina (chest pain)

    • Some antibiotics

    • Other medications for ED

ED medication FAQs

  • How should I take ED medication? 

    You should take ED pills according to the instructions written on the box. Generally speaking, these medications can be taken with or without food. Eating a high-fat meal can slow down the absorption of some medications such as vardenafil. It’s necessary to take ED pills at least 30 minutes up to two hours before sexual activity, depending on the specific drug you’re taking.

  • Who shouldn’t take ED medication?

    Oral ED medication is not right for everyone. In fact, some medical conditions make taking oral ED medication extremely dangerous. ED drugs should not be mixed with the following conditions and/or medications:

    • People taking nitrates, including isosorbide dinitrate and isosorbide mononitrate

    • People who have had a heart attack or stroke in the past 6 months

    • People who have high blood pressure

    This is not a complete list of conditions and it is extremely important to disclose your entire medical history and prescription history to your doctor before being prescribed ED medication.

  • How long does it take for ED medication to work?

    The answer to this question varies from one type of ED medication to another. For example, Viagra and Levitra (sildenafil and vardenafil) take around 30 minutes to work, and their effects can last up to four hours. Tadalafil (Cialis) doesn’t work as fast as Viagra, and it may take one to two hours to work.

    Avanafil (Stendra) is the fastest-acting ED medication. In doses of 100mg and 200mg, Stendra can start working in 15 minutes only. For the 50mg dose, it takes around 30 minutes for Stendra to work.

  • What should I avoid with ED medication?

    You should avoid combining ED pills with certain drugs such as medicines called nitrates, blood thinners, alpha-blockers, and HIV protease inhibitors i.e. medications for the treatment of HIV to reduce the risk of interactions.

    You may also want to avoid taking your ED medication with a large and high-fat meal due to slower absorption, which could impair its effectiveness. Also, you should avoid using ED medication with alcohol. Additionally, you should avoid tweaking the doses or combining your ED pills with other drugs for erectile dysfunction hoping the results would be better.

    Strive to avoid combining prescription drugs that treat ED with unsafe products that promise miraculous results. Focus on a healthy lifestyle instead.

  • Can you buy ED medications over the counter?

    There are over-the-counter ED treatments available; however, they are proven to be less effective than prescription ED medications such as Viagra. After ruling out underlying causes of ED such as heart disease, oral ED medications are often the first line of treatment. Speak with a PlushCare doctor to learn more about getting an online ED prescription.

  • What causes ED?

    There are many potential causes of ED. It’s important to speak with a doctor to make sure an underlying medical condition, such as heart disease, is not causing your ED. Some common causes of ED are: aging, medical conditions, obesity, medication side effects, psychological conditions, drug or alcohol use, tobacco use, injuries.

  • Does ED medication work and what is the safest ED medication?

    Studies show ED medication is effective for about 7 out of 10 men. FDA-approved ED medications, such as Cialis, Viagra, Levitra, and Stendra, are considered safe. While all medications come with the risk of side effects, when prescribed and monitored by a doctor, ED meds are safe. To ensure your safety, always take your ED prescription exactly as instructed by your doctor.

ED medication resources