Zoloft (Sertraline) Prescriptions Available Online Today

Our doctors are here to help. Zoloft (Sertraline) can treat depression, anxiety, and more. Speak to one of our board-certified doctors to see if Zoloft is right for you.

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Our doctors are here to help. Zoloft (Sertraline) can treat depression, anxiety, and more. Speak to one of our board-certified doctors to see if Zoloft is right for you.

Medication services available 24/7 for adults and kids (3+)

Top quality, board-certified doctors

No insurance required

Same-day prescriptions available*

* Prescriptions provided at doctor’s discretion.

3 simple steps to request your prescription online today

Step 1


Visit with a doctor on your smartphone or computer.

Step 2


Visit with a doctor on your smartphone or computer.

Step 3

Pick up

We can send prescriptions to any local pharmacy.

We accept these insurance plans and many more!

Most patients with in-network insurance pay $30 or less. Otherwise, new patient visits are $129 and follow-ups are only $69 for members.

Don’t see your provider listed? Email [email protected]  or call  (888) 564-4454  to talk to a PlushCare specialist.

Can You Get Zoloft Online?

Yes, licensed medical doctors can prescribe Zoloft online. You can legally and safely get a Zoloft prescription online after a consultation with an online doctor.

At PlushCare, you can meet with an online doctor and see if Zoloft (sertraline) is right for you. If the doctor thinks Zoloft can help, they can write you a prescription.

What Is Zoloft (Sertraline)?

Zoloft, also known as sertraline HCl, is a medication that belongs to a class of antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs).  Read on to learn more about how Zoloft can treat depression, generalized anxiety disorder, and other mental health conditions.

Zoloft prescription FAQs

  • What is Zoloft used for?

    Zoloft and other SSRIs are commonly used to treat depression, anxiety, and other mental health conditions.

    Other conditions that Zoloft may be used to treat include premenstrual dysphoric disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorder.

  • How can I get Zoloft prescribed online?

    An online doctor can write you an electronic Zoloft prescription after evaluating you and send it to your local pharmacy. You can book an appointment with one of our board-certified doctors to request a Zoloft prescription from an online doctor.

    Zoloft for depression, anxiety, obsessive compulsive disorder, and other mental health conditions is prescription only, so you will need to speak with a doctor before obtaining any medication.

    PlushCare offers online consultations with doctors and provides prescriptions for medications such as Zoloft (sertraline).

    You can schedule an appointment to consult with a trusted doctor at PlushCare via video chat to see if Zoloft is the right medication for you.

  • Can I get Zoloft without insurance?

    Yes, you can get Zoloft without insurance. Without insurance, brand name Zoloft medication can be quite pricey, but its generic, sertraline HCl, is affordable, ranging from about $7-30 for a monthly supply, depending on if you use a coupon. Talk to one of our PlushCare doctors today to see if Zoloft is right for you.

  • How does Zoloft work?

    Zoloft works by restoring the chemical balance of neurotransmitters in your brain. As a selective serotonin reuptake inhibitor, Zoloft is commonly used in the treatment of mood disorders, such as depression, which are believed to be caused by an imbalance between serotonin and other neurotransmitters in your brain.

    Zoloft can improve your mood, decrease your anxiety, and reduce unwanted thoughts. It can help to improve your sleeping patterns, treat panic attacks, increase your energy level, and bring back your interest in daily tasks.

    Sleep, energy, or appetite may show some improvement within the first 1-2 weeks, according to the National Alliance on Mental Illness. Improvement in these physical symptoms can be an important early signal that the medication is working.

  • What are the side effects of Zoloft?

    Side effects of Zoloft are generally minimal. The most common side effects include:

    • Headache

    • Nausea

    • Loss of appetite

    • Diarrhea

    • Dizziness

    • Constipation

    • Sleepiness

    • Decreased libido

    This is not a complete list of side effects. Always talk to your doctor about potential side effects and drug interactions before taking a new medication. While extremely rare, if you take Zoloft and develop symptoms of an allergic reaction such as a rash, hives, swelling, or trouble breathing, see a doctor to seek medical attention immediately.

    Zoloft pills and other SSRI medications should not be taken in conjunction with monoamine oxidase inhibitor (MAOI) antidepressants.

  • What should you not take with Zoloft?

    Before starting Zoloft, be sure to talk to your doctor if you're currently taking any other medication to avoid potential interactions. Common Zoloft interactions include:

    • St. John's wort

    • Monoamine oxidase inhibitors (MAOIs)

    • Tryptophan

    • Meperidine

    • Tramadol

    • Cimetidine

    • Pimozide

    • Warfarin

    • Nonsteroidal anti inflammatory drugs (NSAIDs)

  • What is the typical Zoloft dosage?

    The typical starting dosage of Zoloft is 50mg taken at the same time, once a day, with or without food. Based on your response to the treatment, the doctor may increase your dosage to 50-200mg per day.

    It is important to keep taking Zoloft even if you feel better.

  • What Zoloft precautions should I be aware of?

    You should not stop taking Zoloft until you consult with your doctor. Stopping Zoloft medication abruptly can cause unwanted side effects and withdrawal symptoms, such as:

    • Headache

    • Tiredness

    • Sleep changes

    • Mood swings

    • Flu-like symptoms

    • Memory impairment

  • Can you get serotonin syndrome on Zoloft?

    Getting serotonin syndrome while taking Zoloft alone is rare. Serotonin syndrome is mainly a concern if you take Zoloft in addition to other medications that contain serotonin, such as other selective serotonin reuptake inhibitors. In most cases, unless you are taking multiple serotonin medications, it is not a risk with Zoloft.

    Seek medical attention immediately if you feel symptoms such as fever, tremors, confusion, or an increased heart rate while taking Zoloft.

  • How does Sertraline work?

    Mood disorders are caused by an imbalance between serotonin and other neurotransmitters in your brain. Medications such as sertraline work by restoring your chemical balance of neurotransmitters.

    When serotonin is taken up by the nerves and then released, this process is known as a re-uptake. SSRIs like sertraline block the reuptake of serotonin. This helps maintain the balance of neurotransmitters in your brain.