Contrave (Naltrexone) Prescriptions Available Online Today

Our doctors are here to help. Contrave can treat weight loss and more. Speak to one of our board-certified doctors to see if Contrave is right for you.

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Our online doctors have treated over 415,000 patients.

An doctor at PlushCare can help you request a prescription online from your phone.

Can You Get Contrave (Naltrexone) Online?

Yes, licensed medical doctors can prescribe Contrave (Naltrexone) online after a medical evaluation.

You can speak with one of our online doctors to learn more about Contrave. Book an online appointment with one of our top doctors using your phone or computer.

During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for Contrave, they can write a prescription and electronically send it to a nearby pharmacy for pickup.

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What Is Contrave (Naltrexone)?

Contrave is a prescription weight loss medication. Contrave is an FDA-approved drug, but it is not a controlled substance, scheduled drug, or stimulant medication.

Contrave is approved for use in adults that have either a body mass index (BMI) of 30 kg/m2 and greater, or adults with a BMI of 27 kg/m2 and greater that have at least one weight-related medical problem such as:

High blood pressure

High cholesterol

Type 2 diabetes

Contrave is meant to be used in conjunction with eating changes and increased physical activity. This medication is not a magical pill, but it can be part of a long-term solution to reduce weight along  with diet and exercise. 

You can get a Contrave prescription online from an online doctor with PlushCare, if you qualify. 

1. Book

Visit with a doctor on your smartphone or computer.

2. Chat

Visit with a doctor on your smartphone or computer.

3. Pick up

We can send prescriptions to any local pharmacy or by mail.

Contrave FAQs

How Does Contrave Work?

Contrave for weight loss is a pill that contains a combination of two drugs: naltrexone hydrochloride and bupropion hydrochloride. These two medications work together to affect the brain in different ways that can impact weight loss. 

  • Bupropion: Bupropion can decrease appetite by affecting the hypothalamus, or hunger center of the brain. This medication can also be used as an antidepressant, and to help people quit smoking. .
  • Naltrexone: Naltrexone can curb hunger and food cravings. It works by altering signals in the mesolimbic circuit in the brain, which is part of the brain’s reward system that can create powerful food cravings, even when you aren’t hungry. 

These two medications together can help to reduce hunger, as well as control cravings, which can lead to sustainable long-term weight loss. Both of these medications have been used separately in other drugs for over 30 years, and have proven to be generally safe for use. 

Although there are other applications for these medications, the Contrave medication combination is NOT FDA-approved to treat:

  • Weight related medical conditions, like high blood pressure or diabetes
  • Depression or other mental illnesses
  • Alcohol or opioid dependency
  • People who need help to quit smoking

How Much Weight Can You Lose On Contrave?

The amount of weight that you can lose on Contrave depends on factors like initial weight, body mass index (BMI), your diet, and your amount of exercise, among other things. Contrave has been through multiple clinical trials in which the efficacy and safety were assessed, along with how much weight was typically lost. 

Of the three clinical trials conducted by the makers of Contrave, each was 56 weeks long, with 2,322 patients total enrolled. Across the studies, the data showed that patients taking Contrave, along with diet and exercise, lost two to four times more weight than with just diet and exercise alone over one year. 

How Quickly Does Contrave Work?

Contrave works relatively quickly, and often results are seen within 12 weeks of starting the medication. If the person taking Contrave has not lost at least 5% of body weight during that time, it is less likely that the drug will cause clinically meaningful weight loss. If there is no change in weight over 12 weeks, Contrave may not be the right drug for you, and your doctor may talk to you about other possibilities to assist in your weight loss efforts.

What Are The Contrave Side Effects?

As with all prescription drugs, Contrave has some side effects. Most side effects are mild and don’t require immediate medical attention, however, there are some possible side effects that are serious and may require immediate evaluation by an in-person physician. 

Common and more mild Contrave side effects may include:

  • Nausea 
  • Vomiting 
  • Diarrhea
  • Constipation
  • Headache
  • Dizziness
  • Dry mouth
  • Sleep problems

More serious and unusual Contrave side effects can include: 

  • Suicidal behavior and ideation 
  • Seizures 
  • Increase in blood pressure and heart rate 
  • Allergic reactions including rashes or anaphylaxis
  • Angle-closure glaucoma 
  • Risk of opioid overdose 
  • Sudden opioid withdrawal 
  • Liver damage or hepatitis 

It is recommended to immediately stop taking Contrave and call your doctor if you experience any of the following: 

  • Severe headache, blurred vision, pounding in your neck or ears, fast heartbeats
  • Seizures
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Changes in mood or behavior – anxiety, depression, panic attacks, trouble sleeping, agitation, thoughts about suicide or hurting yourself;
  • Manic episodes – racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative
  • Liver problems – upper stomach pain, tiredness, dark urine, or jaundice
  • Severe skin reaction – fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling

What Is The Usual Contrave Dose?

Contrave is available in the form of extended-release tablets at the dosage of 8 mg naltrexone/90 mg bupropion. Your doctor will explain the dosage regimen to you, but the table below shows the initial dose and subsequent increases which may be recommended to you. You must take Contrave exactly as prescribed by your doctor. 

You will start with one tablet a day and may increase to four tablets a day by week four if recommended by your physician. This slow increase of the amount of medication you take daily is to reduce the chance of side effects.  

During the first few weeks of taking medication, your doctor will do a re-evaluation to determine if Contrave is working for you and to evaluate any side effects you may be having. And if you haven’t lost at least 5% of body weight after 12 weeks on medication, Contrave may not be the right choice for you. 

Contrave is taken by mouth, with food, but not with high-fat meals, or it could cause side effects. Because it is an extended-release, it has a film coating and cannot be cut, chewed, or crushed, so it must be swallowed whole.

How Much Does Contrave Cost?

A number of factors can impact the cost of Contrave, namely insurance coverage, and where you get your prescription from. If you are insured and your insurance company offers coverage for weight loss medications, your insurance may cover the entire cost, or a large majority of it.

If you are uninsured, discuss Contrave prescription options with your doctor.

Can You Get Contrave Online?

You can get a Contrave prescription online with PlushCare if you qualify. Obesity is now recognized by the US government as a major national health threat. In 2013, obesity was reclassified as a disease with physiological impairments requiring a range of medical interventions for treatment and prevention by the American Medical Association. The reclassification of obesity as a disease has helped reduce stigma and increase the availability of weight management treatments by doctors.


Telehealth is not appropriate for serious conditions that require immediate attention or emergency care. If you experience any life-threatening issues, call 911 or go to an emergency room immediately.


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