Pros
Once-daily dosing
Reduces food cravings and appetite
Helps individuals achieve significant weight loss
Targets two areas of the brain involved in hunger and reward systems
Contrave® is a prescription-only, FDA-approved weight loss pill that may help obese adults with a body mass index (BMI) of 30 kg/m2 or greater lose weight and keep it off. The medication combines two older drugs: naltrexone (an opioid antagonist used to treat alcohol and drug dependence) and bupropion (an antidepressant also used as an adjunct for smoking cessation).
Together, these drugs target both hunger cues and cravings in the brain, helping people to eat less and feel more satisfied after eating. Contrave® is NOT approved to treat depression or other mental illnesses.
Contrave® is available only by prescription.
Contrave® may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.
There is one FDA-approved use for Contrave®, but it may also be used off-label to treat other conditions. Your online clinician may prescribe it for the following reasons. It’s also possible that your healthcare provider may prescribe it for different reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.
Together with diet and exercise, Contrave® is FDA-approved for use as a weight loss medication for :
Adults with body mass index (BMI) of 30 kg/m2 or greater
Adults with a BMI of 27 kg/m2 or greater with at least one weight-related comorbidity (e.g. type 2 diabetes mellitus)
Although there are other applications for these medications, the Contrave® is NOT approved to treat:
Weight-related medical conditions, like high blood pressure or diabetes
Depression or other mental illnesses
Alcohol or opioid dependency
People who need help to quit smoking
Once-daily dosing
Reduces food cravings and appetite
Helps individuals achieve significant weight loss
Targets two areas of the brain involved in hunger and reward systems
May increase the risk of suicidal thoughts
Can interact with many other medications
Can be expensive, especially out-of-pocket
May cause nausea, constipation, headache, vomiting, and insomnia
The side effects associated with taking Contrave® are typically mild. Contrave® has some common side effects. Common possible side effects may include:
Vomiting
Dizziness
Dry mouth
Trouble sleeping
More serious side effects can include:
Increased risk of suicidal thoughts in some children, teenagers, and young adults
Seizures
Increase in blood pressure and heart rate
Chest pain
Allergic reactions, including rashes or anaphylaxis
Angle-closure glaucoma
Risk of opioid overdose
Sudden opioid withdrawal
Liver damage or hepatitis
Increased risk of low blood sugar levels in patients taking type 2 diabetic medication
You should call your doctor if you notice any of these adverse effects or unusual behavior changes.
The FDA has not approved the use of Contrave® in young children under the age of 18.
Your pharmacist will provide you with instructions on how to take your Contrave® prescription.
Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.
According to FDA, Contrave® can come in an extended-release tablet that contains 8 mg naltrexone and 90 mg bupropion, so be sure to follow the specific instructions on your prescription. According to the FDA, Contrave® should be taken orally in the morning and the evening. Below is the recommended dosing schedule:
Week 1: One tablet in the morning
Week 2: One tablet in the morning and one tablet in the evening
Week 3: Two tablets in the morning and one tablet in the evening
Week 4 and onward: Two tablets in the morning and two tablets in the evening
Other specific instructions may include:
Do not cut, chew, or crush the tablets.
Daily doses should not exceed 32 mg/360 mg (two tablets twice daily).
Contrave® can be taken with meals but not high-fat meals.
It is essential to take Contrave® precisely as your healthcare professional prescribes, as higher or more frequent doses can increase the risk of side effects.
Contrave® has 700 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other prescription drugs or supplements, as well as over-the-counter medications.
Here's a list of things you should avoid while taking Contrave®:
Don't drink alcohol. It can increase the risk of seizures.
Don't take other medications that also contain bupropion. This includes Wellbutrin/Wellbutrin XL/Wellbutrin SR.
Don't take Contrave® if you have an eating disorder.
Don't take Contrave® if you're pregnant or planning to become pregnant. It's unknown if the medication passes into breast milk and could harm a nursing baby.
Don't take Contrave® if you have kidney problems.
Don't take Contrave® if you are on monoamine oxidase inhibitors (MAOIs).
Don't take Contrave® if you are on opioid pain medicines. Discontinue these opioid-containing medicines 7 - 10 days before taking Contrave® to avoid opioid withdrawal symptoms. There is also the risk of opioid overdose.
In some cases, your clinician may prefer to put you on another treatment altogether. In that case, they may suggest a weight loss medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:
There are a few weight loss medication alternatives to Contrave®. These include:
This drug is used to treat diabetes primarily. The other use of this medicine is indicated to aid weight management in adults with excess weight or obesity.
This medication can be prescribed to achieve clinically meaningful weight loss in obese adults with high cholesterol or BP problems.
Contrave® is only available by prescription, so you will need to see a board-certified doctor for a prescription. To begin, book a virtual appointment with one of our top rated board-certified doctors. Attend the visit with one of our clinicians from the comfort of your phone or computer. After a qualifying evaluation, they will send a prescription to your local pharmacy for pickup.
Contrave® is a combination of naltrexone, an opioid antagonist, and bupropion, an antidepressant also used for smoking cessation.
In conjunction, these drugs address cravings and hunger cues in the brain. This can help individuals reduce their food intake and feel more full after meals.
According to the manufacturer of Contrave®, Currax Pharmaceuticals, the cost of 30 day supply of Contrave® through their CurAccess program is $90. It can be even lower with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.
It usually takes a few weeks for Contrave® to kick in. You may see the medication's full effect once you have taken it for several months, together with diet and exercise.
Following your healthcare provider's directions, patients typically begin with pills in the morning during the first week and slowly increase their dosage to 2 pills twice a day by week 4.
Contrave® is not recommended for people that
Are taking bupropion-containing medicines such as Wellbutrin, Aplenzin, or Zyban
Have or have had an eating disorder
Have developed a physical dependence on opioid pain medicines or are in opioid withdrawal
Drink high amounts of alcohol
Are on medications such as monoamine oxidase inhibitors (MAOIs)
Are allergic to naltrexone, bupropion, or any of the ingredients in Contrave®
Have uncontrolled hypertension
Have or have had seizures
You should not take Contrave® if you have an eating disorder, kidney disease, or are pregnant or breastfeeding. You should also avoid taking Contrave® if taking other medications containing bupropion.
If you miss a dose of Contrave®, skip the missed dose and take your next dose at the regular time. Do not take two doses of Contrave® at the same time.
Taking too much Contrave® can increase the risk of side effects, including seizures. If you think you have taken too much Contrave®, call healthcare professionals or Poison Control Center immediately.
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Step 3
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How pricing works
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PlushCare is dedicated to providing you with accurate and trustworthy health information.
CONTRAVE (naltrexone HCl and bupropion HCl), Extended-Release Tablets Label, Accessed October 10, 2023, https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/200063s000lbl.pdf
Contrave (n.d.). Accessed October 10, 2023, https://contrave.com/
National Library of Medicine, "Naltrexone/Bupropion ER (Contrave)" Accessed October 10, 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771085/
DailyMed. "Drug Label Information: [Include Set ID]." National Institutes of Health, U.S. National Library of Medicine. Accessed October 10, 2023, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=485ff360-32c8-11df-928b-0002a5d5c51b
PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.