Cologuard prescription available online 

Cologuard is an at-home colon cancer screening test that detects colon cancer and traces of blood in the stool that precancerous polyps and colon cancer can cause. Find out how simple it is to get tested for colon cancer today.*

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Telehealth access to prescribe Cologuard kits

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Reliable colorectal cancer testing from home

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Cologuard 

Cologuard is a screening test for colorectal cancer (colon cancer and rectal cancer). Cologuard detects changes in your DNA that could indicate colon cancer or precancerous polyps, which may develop into cancer.

Cologuard is used to detect colorectal cancer. Cologuard is available only by prescription, and your doctor will need to prescribe the colorectal cancer screening test before you're able to order a Cologuard kit.

Cologuard kits include a bracket, collection bucket, probe, and lab tube set to collect your stool sample and send it back to the lab for testing. It’s always important to follow the specific instructions on your test kit.

A positive result indicates that further cancer testing is needed. A negative test result may help you avoid a colonoscopy based on your doctor's advice.

Cologuard uses

  • Cologuard is an FDA-approved colorectal cancer screening test. Cologuard is designed to detect DNA markers in cancer that are shed from the colon as part of the digestive process.

    Cologuard, which is available through healthcare providers, offers people 50 and older at average risk for colorectal cancer an easy-to-use screening test. If you have a personal or family history of colorectal cancer, your healthcare provider may recommend regular screening tests.

    After your healthcare provider prescribes your colon cancer screening kit, the kit will be sent directly to your home. Then, you can collect a stool sample and send it back to the lab for testing.

Cologuard side effects

  • Cologuard testing has potential drawbacks, mostly involving the accuracy of the screening test. According to a 2018 review, stool sample testing is not as accurate as a colonoscopy when detecting precancerous polyps or lesions.

    False positives can create unnecessary stress and worry while waiting for follow-up test results. Because Cologuard testing produces high levels of false negatives, it's important to talk to your healthcare provider before taking the test.

    A false-negative test result—or missing the presence of colorectal cancer—is also possible. In a 2014 study, the false-negative rate was higher for larger polyps. Since Cologuard tests are relatively new, there are not yet any long-term data on how this screening method will affect your outlook if you have colon cancer.

    You should call your doctor if you have any concerns about the preventive screening, or if you develop any other new or concerning symptoms.

How to take Cologuard

Your pharmacist will provide you with instructions on how to use your Cologuard prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Your test kit will come with everything you need to collect a stool sample. Using the bracket and collection bucket that comes with your Cologuard test, you can have a bowel movement that goes directly into the collection bucket. Then, you'll use the plastic probe to collect a sample and place it in the tube.

After collecting your stool sample, pour the preservation solution into the kit and screw on the lid. Make sure to fill out your personal information, including the date and time of your sample collection. Finally, ship the testing box back to the lab within 24 hours.

What to avoid while taking Cologuard

When taking your Cologuard test, don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

Avoid multitarget stool DNA testing if:

  • You have diarrhea.

  • You're currently menstruating.

  • You have rectal bleeding due to hemorrhoids.

Medication alternatives to Cologuard

If your healthcare professional prefers another type of colorectal cancer screening, they may suggest another stool sample test. Here are some common doctor-recommended alternatives based on your health issue:

  • Colon cancer screening

    • Everlywell

    • LetsGetChecked

    • Pixel by Labcorp

Cologuard prescription FAQs

  • How much does Cologuard cost?

    Cologuard test kits can range from $581 to $681 without insurance.

    Most health insurance plans, including Medicare, cover Cologuard. If you're eligible for colon cancer screening and have health insurance, you may be able to get a Cologuard prescription without any out-of-pocket costs.

  • How can I refill my Cologuard prescription?

    To refill your Cologuard prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your medical history, your doctor can send an electronic prescription to your local pharmacy.

  • When should you not use Cologuard?

    Avoid using Cologuard if:

    • You have diarrhea.

    • You're currently menstruating.

    • You have rectal bleeding due to hemorrhoids.

    Read the instructions on your test kit carefully. Wait until you're ready to have a bowel movement to use your Cologuard test. Make sure you can ship the sample within 24 hours.

  • Does Cologuard need to be refrigerated? 

    No, Cologuard does not need to be refrigerated. Store the testing box at room temperature away from direct sunlight and heat.

  • How much stool do I need for Cologuard?

    When collecting your stool sample, your sample should be no larger than the bottle of preservative.

  • What happens if I miss a dose of Cologuard?

    Because Cologuard is a colorectal testing kit, you won't miss a dose.

  • What happens if I take too much Cologuard?

    Because Cologuard is a colorectal testing kit, there's no risk of overdose.

3 simple steps to request your Cologuard prescription today 

Step 1

Book a Cologuard prescription request appointment.

You can book a same-day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Cologuard prescription.

You can visit a doctor on your smartphone or computer.

Step 3

Pick up your Cologuard prescription.

We can send prescriptions to any local pharmacy.

How to talk to your doctor about Cologuard: helpful questions to ask

Taking charge of your colon health is important. At PlushCare, we prioritize preventive care and making sure you have the information you need. If you're considering ColoGuard for colorectal cancer screening, here are some helpful questions to discuss with your doctor during your appointment:

  • What are the pros and cons of Cologuard versus other diagnostic tests? 

  • Is Cologuard helpful if I have a family history of colon cancer?

  • How long will it take to receive test results?

  • What should I do if I suspect a false positive or negative?

  • If I do receive a false result, how long should I wait before taking another test?

  • What are the limitations of an at-home test compared to a colonoscopy?

  • Are there any alternative at-home tests that you can recommend?

  • If my results are positive, what are the next steps for evaluation?

  • What can I expect from a follow-up appointment?

Cologuard prescription pricing details

How pricing works

To get Cologuard, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.