Zofran (ondansetron) prescription available online 

If you are suffering from nausea or vomiting, Zofran (ondansetron) can help. Get a new prescription or refill of Zofran from a board-certified doctor online.*

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Quick and rapid relief

Available as orally disintegrating tablets

Ease nausea and upset stomach

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Zofran (ondansetron)

Zofran is considered an antiemetic, which is used to treat or prevent nausea, vomiting, and upset stomach. Antiemetics are prescription-only medications used to treat nausea and upset stomach.

Some conditions that Zofran is known to treat include generalized nausea, nausea and vomiting caused by chemotherapy, postoperative nausea, gastroparesis, pregnancy-associated nausea, gastroenteritis, and more. Zofran is available only by prescription. It is available in a generic formulation as ondansetron and is well known under the brand name, Zofran.

Zofran (ondansetron) is commonly prescribed as orally disintegrating tablets. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage that you are prescribed.

If you are prescribed Zofran, be sure to complete the full course of the antiemetic unless your doctor specifically tells you to stop. The antiemetic may not fully treat or prevent nausea and vomiting if you don't complete your prescription. 

Zofran uses

Zofran has many FDA-approved uses, but it may also be used off-label to treat other conditions. Your online clinician may prescribe it for any of the following common reasons. It’s also possible that your doctor may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed

  • Nausea and vomiting

    Zofran is approved for the prevention of nausea and vomiting before surgery, to reduce chemotherapy-induced nausea, to treat nausea caused by radiation therapy, and to treat stomach-virus-induced nausea.

Zofran (ondansetron) side effects

  • The side effects associated with taking ondansetron are typically mild to moderate. Most ondansetron side effects are associated with generalized symptoms. Common side effects of Zofran include:

    Other side effects, which are less common but might be more severe, could include:

    • Trouble passing urine

    • Signs of an allergic reaction like hives, rash, itching, redness, or peeling skin

    • Dizziness

    • Sudden chest pain or chest tightness

    Although it may be rare, some people may have very bad side effects. Tell your doctor and seek medical help immediately if you have any of these side effects or if you develop any other new or concerning symptoms.

How to take Zofran

Your pharmacist will provide you with instructions on how to take your Zofran prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Zofran can come in different forms and doses, so be sure to follow the specific instructions on your prescription. It is typically prescribed as needed as an orally disintegrating tablet every 4 to 12 hours. The frequency you are able to take oral ondansetron depends on the dose and your prescription. Make sure to follow instructions closely and read all information that is given to you.

What to avoid while taking Zofran

Zofran has several interactions with certain medications. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. Some common drug interactions include:

  • Zoloft (sertraline)

  • Tramadol

  • Desyrel (trazodone)

  • Cymbalta (duloxetine)

It is important to tell your doctor if you have a long QT on an ECG when taking Zofran.  

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Zofran. Some research shows that regular alcohol consumption may alter the way medications work.

Medication alternatives to Zofran (ondansetron)

If your physician prefers to put you on another treatment altogether, they may suggest another antiemetic or a nausea medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Nausea and vomiting

    Compazine (prochlorperazine)

    Reglan (metoclopramide)

    Motilium (domperidone)

Zofran prescription FAQs

  • What is Zofran used for?

    Zofran is used to treat nausea, prevent vomiting, and treat upset stomach.

  • How often can you take Zofran?

    Depending on the dose, you can take Zofran as needed every 4 to 12 hours.

  • How long does Zofran take to work?

    Zofran can begin working within 30 minutes after taking the first dose.

  • How long does Zofran last?

    The effects of Zofran peak about two hours after the first dose. Zofran stays in your system anywhere from 2-12 hours.

  • What is ondansetron mainly used for?

    Ondansetron is mainly used to treat nausea and prevent vomiting.

  • Is ondansetron and Zofran the same drug?

    Ondansetron is the generic version of Zofran. They consist of the same drug.

  • Does Zofran stop nausea immediately?

    Zofran can start working to treat nausea in less than 30 minutes after taking the initial dose.

  • Is Zofran generic over the counter?

    Zofran is a prescription-only medication.

  • How much does Zofran cost?

    The generic for Zofran, ondansetron, costs around $15 for a 20-tablet supply of 4 mg tablets. PlushCare members can find the lowest price at nearby pharmacies and save up to 80% on prescriptions with our in-app Rx Price Finder and prescription discount card.

  • How can I refill my Zofran prescription?

    Zofran is only available by prescription, so you can book an appointment with one of our board-certified doctors to get a refill on your prescription online. Your prescription will then be sent to your local pharmacy for pickup if you qualify.

  • What happens if I take too much Zofran?

    Too much Zofran can cause abnormal heartbeats, liver failure, kidney failure, or possibly a life-threatening condition called serotonin syndrome. If you've taken too much Zofran, contact your local poison control center or seek emergency medical attention immediately.

  • How do I get ondansetron (generic Zofran) over the counter?

    Ondansetron (the generic version of Zofran) is not available over the counter and requires a prescription from a doctor. While managing nausea and vomiting can be frustrating, getting a proper diagnosis and treatment is key. A doctor's supervision ensures you get the right medication and dosage to effectively relieve your nausea and vomiting.

    Our board-certified physicians are available 24/7 for convenient virtual doctor consultations. Your doctor will help identify the underlying cause of your nausea and vomiting, which might require additional treatment. They will also take your full health history and consider any potential side effects of ondansetron specific to you and ensure it doesn't interact with any other medications or supplements you're taking.

3 simple steps to request your Zofran prescription today 

Step 1

Book a Zofran prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your clinician regarding your Zofran prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Zofran prescription.

We can send prescriptions to any local pharmacy.

Zofran prescription pricing details

How pricing works

To get a new or refill on your Zofran prescription online, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.