Antifungal prescriptions available online

Learn how antifungal medications can help treat fungal infections with a consultation from one of our board-certified doctors online. Get a new prescription or refill for antifungal medications from a top-rated doctor online.*

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About antifungal medications

Antifungal medications are medications designed to treat fungal infections. They’re often prescribed to help treat yeast infections, ringworm, and skin and nail infections, they're used for other fungal infections as well. There are many types of prescription antifungal medications. 

What antifungal medications treat

The most common condition treated with antifungal medications is fungal skin infections. Antifungals are medicines that kill or prevent the growth of fungi. By targeting structures or functions that are necessary in fungal cells but not in human cells, antifungal drugs can fight a fungal infection without damaging your body's cells. When the fungal cell membrane or fungal cell wall becomes compromised, the fungal cell will die.

While most fungi cause no problems and infections are easily treatable, people with a weakened immune system are more likely to develop serious fungal infections. Other conditions also treated with antifungals include Candida infections, athlete's foot, and oral thrush.

Types of antifungal medications available online

The main types of antifungal medications are called azoles, polyenes, allylamines and echinocandins.

  • Azoles

    Azoles are most often used to treat skin and mucous membrane infections. As some of the most commonly used antifungal drugs, azoles interfere with an enzyme that's important for creating the fungal cell membrane. As a result, the fungal cell becomes unstable, leading to cell death.

    Examples of azoles include:

    Diflucan (fluconazole)

    Nizoral (ketoconazole)

    Lotrimin AF (clotrimazole)

    Terazol (terconazole)

    Sporanox (itraconazole)

  • Polyenes

    Polyenes kill fungal cells by increasing the porosity of the fungal cell wall. In turn, polyenes compromise the fungal cell, which makes the cell prone to bursting. Polyene antifungal medicines are often used to treat Candida yeast infections, including mucosal or invasive Candida infections.

    Examples of polyenes include:

    Ambisone (amphotericin B)

    Nystop (nystatin)
  • Allylamines

    Allylamines are a class of antifungal drugs that inhibit the enzyme squalene epoxidase, which is necessary for the synthesis of ergosterol, an important component of fungal cell membranes. This results in an accumulation of squalene and a deficiency of ergosterol within the fungal cell leading to cell death.

    Examples of allylamines include:

    Lamisil (terbinafine)

  • Echinocandins

    Echinocandins are a newer type of antifungal drug. Echinocandins inhibit an enzyme that makes up the fungal cell wall, which leads to cell death. Similar to polyene antifungal medicines, they're often used to treat invasive fungal infections, such as Candida infections. This drug class is typically administered by intravenous infusion and not available as a prescription at PlushCare.

    Examples of echinocandins include:

    Eraxis (anidulafungin)

    Cancidas (caspofungin)

    Mycamine (micafungin)

How antifungal medications work

Antifungals work by killing or preventing the growth of fungi, which commonly affect the skin, hair, and nails. Antifungal drugs target the fungal cell membrane and fungal cell wall, which surround and protect fungal cells. When these structures are compromised, the cell bursts open, causing the contents to leak out and eventually die.

  • Side effects of antifungal medications

    When taken as prescribed, antifungal medicines are generally well tolerated. However, they can still cause some side effects.

    The more common side effects of antifungal drugs include:

    • Abdominal pain, upset stomach, and diarrhea

    • Skin rash, itchy skin, or burning sensation

    In rare cases, antifungal medicines may cause serious side effects. These can include:

    • Signs of liver damage, such as jaundice

    • Severe allergic reaction

    • Severe skin reactions, such as blisters and peeling skin

  • Antifungal medications risks

    Antifungal medications are generally safe, but there are some risks if you have other medical conditions or take certain medications.

    Before you take a prescribed antifungal, be sure to tell your doctor if you have any of the following conditions or issues:

    • Liver disease

    • Heart problems

    • Immune disorders, such as HIV/AIDS or lupus

    • Allergic reaction to antifungal drugs

  • Antifungal medications drug interactions 

    When you begin a new medication, make sure to tell your doctor about any other medications, supplements, or herbs you’re taking. Some medications that might interact with an antifungal include:

    • Other antibiotic, antifungal, or antiviral medicines

    • Blood thinners

    • Cholesterol medication

    • Oral diabetes medicine

    • Heart or blood pressure medication

    • Nonsteroidal anti-inflammatory drugs (NSAIDs)

Antifungal medications FAQs

  • How should I take antifungal medications? 

    Always take antifungal medicine as prescribed by your healthcare provider. There are over-the-counter (OTC) and prescription antifungal medicines available. Make sure to talk to your healthcare professional to determine the best treatment for your fungal infection.

    Antifungal drugs come in several forms, including:

    • Injections (shots) or IV

    • Oral pills and liquids

    • Topical treatment, including skin creams, ointments, gels, and sprays

    • Vaginal suppositories

    The length of antifungal treatment will depend on the fungal infection. While most fungal diseases, such as ringworm, clear up in a few weeks, other infections can take months or years to go away. More serious fungal infections, including blood and lung infections, may require long-term treatment.

  • Who shouldn’t take antifungal medications?

    The safety of antifungal medicine varies depending on the drug. Make sure to tell your healthcare professionals if you have certain medical conditions, such as:

    • You're currently pregnant or breastfeeding

    • Liver or kidney disease

    • Heart rhythm disorder

    • History of QT prolongation

    • Immune disorders, such as HIV/AIDs, lupus, or cancer

    • Allergic reaction to antifungals

    You should not take an antifungal medicine to treat a viral or bacterial infection. After reviewing your medical history and fungal infection symptoms, your healthcare provider can determine whether it's safe for you to take an antifungal drug.

  • How long does it take for antifungal medications to work?

    For vaginal yeast infections or fungal balanitis, an antifungal typically starts working within one to three days. If a single antifungal dose does not help improve symptoms or if the infection is severe, your healthcare provider may prescribe additional doses.

    If your symptoms continue after short-term antifungal treatment, your healthcare provider may choose to prescribe the medication for an extended period of time. If you have a weakened immune system caused by cancer treatment, bone marrow transplant, or immune disorders such as AIDs, you may require long-term treatment to prevent more serious fungal infections.

  • What should I avoid with antifungal medications?

    Avoid taking certain medications while taking an antifungal, such as:

    • Other antifungal drugs, antibiotics, or antiviral medications

    • Cholesterol and blood pressure medication

    • Oral diabetes medicine

    • Nonsteroidal anti-inflammatory drugs (NSAIDs)

    • Blood thinners

    Talk to your doctor before drinking alcohol on antifungals. Alcohol may increase your risk of adverse effects, such as nausea, diarrhea, and upset stomach.

    Always take your antifungal medicine as directed by your doctor. Improper use of antifungals can lead to antifungal resistance, which can make it harder for your body to fight a fungal infection.

  • What does an antifungal do?

    In general, antifungals fight fungal infections in two ways: by directly killing fungal cells or preventing cells from growing and multiplying. Antifungal drugs target structures that are necessary in fungal cells but not in human cells. In turn, they can fight fungal infections without harming your body's cells.

    Antifungal medicines commonly target the fungal cell membrane and cell wall. When these structures become damaged, they cannot protect the fungal cell, causing the cell to burst open and die. Other antifungal medications work by stopping the creation of the cell membrane.

  • What are some of the types of antifungal drugs?

    Some of the types of antifungal medications include azoles, polyenes, allylamines and echinocandins. Each type of antifungal medicine works differently to treat fungal infections. After discussing your symptoms and medical history with your healthcare provider, your doctor can help you choose the best antifungal treatment for your fungal infection.

  • What is a natural antifungal?

    Natural antifungals are natural supplements that can help you avoid the side effects and antifungal resistance that comes with synthetic drugs. Popular antifungal drugs include grapefruit seed extract, oregano oil, and caprylic acid. Although adding natural antifungals to your diet may help with treatment, be sure to talk to your doctor before using natural antifungals in place of medication to treat a fungal infection.

3 simple steps to getting antifungal medications online 

Step 1

Book an appointment to discuss antifungal medications.

Book a same day appointment from anywhere.

Step 2

Talk to your doctor online.

See a doctor on your smartphone or computer.

Step 3

Pick up your antifungal medications.

We can send antifungal medications to any local pharmacy.

Antifungal medications pricing details

How pricing works

To get antifungal medications online, join our monthly membership and get discounted visits.

Paying with insurance



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  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

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  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.