Lotrel for high blood pressure: online prescription available (same-day)

If you are suffering from high blood pressure (hypertension), Lotrel can help. Lotrel combines two active ingredients, amlodipine and benazepril, which work together to help relax blood vessels and improve blood flow, helping to lower blood pressure. Get a new prescription or refill of Lotrel from a caring, board-certified doctor online.*

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Combination of amlodipine and benazepril

FDA-approved for hypertension

Follow full course for effective hypertension treatment

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Lotrel (amlodipine and benazepril)

Lotrel is a combination of amlodipine and benazepril, a calcium channel blocker and angiotensin-converting enzyme (ACE) inhibitor, respectively. Amlodipine relaxes blood vessels and improves blood flow, while benazepril prevents the body from retaining water.

Lotrel is used to treat high blood pressure (hypertension). Lotrel is available only by prescription. It is available in a generic formulation as well as under different brand names, including amlodipine and benazepril.

Lotrel may be prescribed as an amlodipine and benazepril capsule. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Lotrel, be sure to complete the full course of the blood pressure medicine unless your doctor specifically tells you to stop. If you don’t complete your prescription, the blood pressure medicine may not fully treat your high blood pressure.

Lotrel for high blood pressure

Lotrel is FDA-approved to treat high blood pressure. Your doctor may also prescribe it off-label to treat other conditions. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • High blood pressure

    Lotrel is FDA-approved to treat high blood pressure. Lotrel is not typically prescribed as a first-line treatment for hypertension. Instead, it's given to hypertensive patients treated with another hypertensive agent who have not achieved adequate blood pressure control.

Lotrel side effects

The side effects associated with taking Lotrel are typically mild. Most Lotrel side effects are associated with dizziness. Lotrel has some common side effects. They may include:

    • Dizziness

    • Sweating

    • Swelling in your hands or feet

    Other side effects, which are less common but might be more severe, could include:

    • New or worsened chest pain

    • Signs of liver problems (severe stomach pain, unusual tiredness, dark urine)

    • High potassium levels

    • Rapid weight gain

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. It is not known whether amlodipine and benazepril are safe and effective in young children.

How to take Lotrel (benazepril/amlodipine)

Your doctor or pharmacist will provide you with instructions on how to take your Lotrel prescription. Be sure to read your Lotrel prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Lotrel can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The initial dose of Lotrel is typically 2.5 mg and 10 mg of amlodipine and benazepril once daily, respectively. Your doctor may increase your dose as needed to treat your high blood pressure.

What to avoid while taking Lotrel

Lotrel has 649 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with amlodipine and benazepril include:

Talk to your doctor before drinking alcohol. Drinking alcohol while taking amlodipine and benazepril can cause low blood pressure. Avoid driving or hazardous activity until you know how Lotrel affects you.

Medication alternatives to Lotrel

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another blood pressure medicine in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Lotrel prescription FAQs

  • How much does Lotrel cost?

    Depending on your pharmacy, Lotrel (5 mg/10 mg) costs around $1,059 for 100 capsules without insurance. Fortunately, generic brands, such as amlodipine and benazepril, can offer an affordable alternative. Price also varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How long does it take for Lotrel to lower blood pressure?

    Lotrel typically takes 1–2 weeks to lower blood pressure.

  • Can you drink alcohol while taking Lotrel?

    Talk to your doctor before drinking alcohol while on Lotrel. Alcohol can have additive blood pressure-lowering effects, which can lead to adverse reactions.

  • Does Lotrel cause weight gain?

    Yes, weight gain is a possible side effect of Lotrel. Talk to your doctor if you experience rapid weight gain while taking this prescription medication.

  • How can I refill my Lotrel prescription?

    To refill your Lotrel prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your medical history, your doctor can send an electronic prescription to your local pharmacy if you qualify.

  • What medications should not be taken with Lotrel?

    Possible drug interactions with Lotrel include:

    • Nonsteroidal anti-inflammatory drugs, including aspirin, Advil (ibuprofen), and Aleve (naproxen)

    • Other heart or blood pressure medicine

    • Antibiotic, antifungal, or antiviral medications

    • Insulin or oral diabetes medicine

    • Diuretics (water pills)

    • Potassium supplements

    You should not take Lotrel if you've recently taken a heart medicine called sacubitril. Diabetic patients should not take amlodipine and benazepril with any medication that contains aliskiren.

  • Who should not take Lotrel?

    To make sure amlodipine and benazepril are safe for you, tell your doctor if you have:

    • Angioedema (hives or swelling of deep skin tissues due to an allergic reaction)

    • Serious allergic reactions to calcium channel blockers or ACE inhibitors

    • Heart disease or congestive heart failure

    • High potassium levels

    • Kidney disease or acute renal failure

    • Liver disease

    • Diabetes

  • What happens if I miss a dose of Lotrel?

    If you miss a dose of Lotrel, take the missed dose as soon as you remember. Skip the missed dose if you're over 12 hours late for the missed dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Lotrel?

    If you've taken too much Lotrel, seek emergency medical attention or contact your local poison control center.

3 simple steps to request your Lotrel prescription for high blood pressure

Step 1

Book a Lotrel prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Lotrel prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Lotrel prescription.

We can send prescriptions to any local pharmacy.

Lotrel prescription pricing details

How pricing works

To get a new or refill on your Lotrel prescription, join our monthly membership and get discounted visits.

Paying with insurance



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30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.