Glucophage (metformin hydrochloride) prescription available online 

If you are suffering from type 2 diabetes mellitus, Glucophage (metformin hydrochloride) can help. Get a new prescription or refill of Glucophage from a board-certified doctor online.*

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Control high blood sugar

Available as an oral tablet or oral solution

Tailored type 2 diabetes treatment

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Glucophage (metformin hydrochloride)

Glucophage, an oral anti-hyperglycemic drug, works by restoring the body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver produces and that your stomach and intestines absorb.

Glucophage is used to treat type 2 diabetes mellitus. Glucophage is available only by prescription. It is available in a generic formulation as well as under different brand names, including metformin hydrochloride.

Glucophage may be prescribed as an oral tablet or oral solution. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Glucophage, be sure to complete the full course of the oral anti-hyperglycemic unless your doctor specifically tells you to stop. If you don’t complete your prescription, the anti-hyperglycemic may not fully treat your type 2 diabetes mellitus.

Glucophage uses

There is 1 FDA-approved use for Glucophage, but your healthcare provider may also prescribe it off-label to treat other medical conditions.

Your doctor may prescribe Glucophage for any of the following reasons, or other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Type 2 diabetes mellitus

    Glucophage is FDA-approved to treat type 2 diabetes mellitus in adult and pediatric patients. Glucophage is used together with diet and exercise to improve blood sugar control and insulin sensitivity.

    Glucophage is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis.

Glucophage side effects

The side effects associated with taking Glucophage are typically mild. Most Glucophage side effects are associated with nausea.

  • Glucophage has some common side effects. They may include:

    • Low blood sugar levels

    • Nausea or upset stomach

    • Diarrhea

    Other side effects, which are less common but might be more severe, could include:

    • Stomach pain or vomiting

    • Lightheadedness

    • Unusual muscle pain

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms.

    In very rare cases, Glucophage can lead to an increased risk of lactic acidosis. If you have decreased kidney function or other risk factors for lactic acidosis, your doctor will monitor you regularly to make sure Glucophage is safe for you.

How to take Glucophage (metformin hydrochloride)

Your pharmacist will provide you with instructions on how to take your Glucophage prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Glucophage can come in different forms and doses, so be sure to follow the specific instructions on your prescription.

For patients with normal renal function, the initial starting dose for immediate-release Glucophage is typically 500 mg orally twice daily or 850 orally once daily, while the starting dose for Glucophage XR (extended-release) ranges from 500 to 1000 mg orally once daily.

What to avoid while taking Glucophage

Glucophage has 355 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Glucophage include:

  • Crestor (rosuvastatin)

  • Cymbalta (duloxetine)

  • Lasix (furosemide)

  • Norvasc (amlodipine)

  • Prilosec (omeprazole)

Excessive alcohol intake should be avoided when taking metformin therapy. Excessive alcohol intake while taking metformin can increase your risk of lactic acidosis. Alcohol may also affect your blood glucose levels.

Medication alternatives to Glucophage

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another oral anti-hyperglycemic drug or blood glucose control medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Glucophage prescription FAQs

  • How much does Glucophage cost?

    Depending on your pharmacy, Glucophage costs around $34 for thirty 500 mg tablets. Fortunately, generic brands, such as metformin, can offer an affordable alternative. Price varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my Glucophage prescription?

    Glucophage is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Who should not take Glucophage?

    Avoid taking metformin if you have certain medical conditions, such as:

    • Severe kidney disease or impaired kidney function

    • Metabolic acidosis or diabetic ketoacidosis

    • Liver disease or decreased liver function

    • Heart disease or congestive heart failure

    Tell your doctor if you have a severe infection, excessive alcohol intake, renal impairment, or if you're 65 or older, as these risk factors can increase your risk of lactic acidosis.

  • What time of day should Glucophage be taken?

    Take Glucophage with a meal unless your doctor tells you otherwise. Glucophage XR should be taken once daily following your evening meal.

  • Why should Glucophage be taken at night?

    Taking metformin at night can help improve glycemic control by reducing morning hyperglycemia (high blood sugar).

  • What happens if I miss a dose of Glucophage?

    If you miss a dose of Glucophage, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Glucophage?

    If you've taken too much Glucophage, seek emergency medical attention or contact your local poison control center. An overdose of Glucophage can cause a medical emergency, such as severe hypoglycemia (low blood sugar) or lactic acidosis.

3 simple steps to request your Glucophage prescription today 

Step 1

Book a Glucophage prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Glucophage prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Glucophage prescription.

We can send prescriptions to any local pharmacy.

How to talk to your doctor about Glucophage (metformin hydrochloride):

At Plushcare, our priority is making sure you receive the information and advice you need when making decisions about your health and wellness. Our board-certified doctors are here to help you every step of the way, focusing on genuine patient connection to help you feel confident and secure in your treatment journey.

The following are some questions to ask your doctor about Glucophage and type 2 diabetes mellitus:

  • What dosage of Glucophage is right for me, and are we able to adjust it as needed?

  • How long do you think I will need to be on this medication?

  • How can I best manage the side effects of Glucophage?

  • Will Glucophage interact with any of my current medications?

  • In addition to this medication, what additional treatments can help manage my diabetes?

  • How often should I monitor my blood sugar while taking this medication?

  • Will Glucophage affect my diet and exercise needs?

  • How will we track if this medication is working for me, and how often will I need to make follow up appointments?

Glucophage prescription pricing details

How pricing works

To get a new or refill on your Glucophage prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.