Amaryl (glimepiride) prescription available online 

If you are suffering from type 2 diabetes mellitus, Amaryl (glimepiride) can help. Get a new prescription or refill of Amaryl from a board-certified doctor online.*

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Effective in combination with diet and exercise

Treats adults with type 2 diabetes mellitus

Take control of your blood sugar levels

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Amaryl 

Amaryl, a sulfonylurea, helps lower blood sugar by promoting the release of your body's natural insulin. In combination with a healthy diet and exercise, Amaryl can help control blood sugar levels in adults with type 2 diabetes mellitus.

Amaryl is available only by prescription. It is available in a generic formulation as glimepiride, as well as under different brand names.

Amaryl may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you are prescribed Amaryl, be sure to complete the full course of the diabetes drug unless your doctor specifically tells you to stop. If you don’t complete your prescription, the sulfonylurea may not fully treat your type 2 diabetes mellitus.

Amaryl uses

There is one FDA-approved use for Amaryl, but your healthcare professional may also prescribe it off-label to treat other medical conditions.

Your PlushCare doctor may prescribe Amaryl for any of the following reasons, or other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Type 2 diabetes mellitus

    Amaryl is FDA-approved to treat type 2 diabetes in adults. Amaryl is prescribed in combination with a healthy diet and exercise to improve blood sugar. It is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis.

Amaryl side effects

  • The side effects associated with taking Amaryl are typically mild. Most Amaryl side effects are associated with dizziness.

    Amaryl has some common side effects. They may include:

    • Dizziness or weakness

    • Headache

    • Low blood sugar

    • Nausea

    Other side effects, which are less common but might be more severe, could include:

    • Severe low blood sugar (hypoglycemia)

    • Confusion

    • Pale, yellow skin or dark-colored urine

    • Fever

    • Allergic reaction

    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. The use of Amaryl is not recommended in children, as it can cause extreme weight gain and severe hypoglycemia (low blood sugar).

How to take Amaryl

Your pharmacist will provide you with instructions on how to take your Amaryl prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Amaryl can come in different doses, so be sure to follow the specific instructions on your prescription. The recommended starting dose for adults with type 2 diabetes is 1–2 mg orally once a day.

What to avoid while taking Amaryl

Amaryl has 449 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications, supplements, and other drugs.

Possible drug interactions with Amaryl include:

  • Aspirin

  • Lasix (furosemide)

  • Lipitor (atorvastatin)

  • Norvasc (amlodipine)

  • Plavix (clopidogrel)

If you're also taking colesevelam, take your Amaryl dose at least four hours before taking colesevelam.

Amaryl can increase your sensitivity to sunlight. Wear protective clothing and use sunscreen when outdoors.

Drinking alcohol can affect blood glucose levels in people with diabetes, which can lead to an increased risk of low blood sugar or high blood sugar. Talk with your doctor before drinking alcohol while taking Amaryl.

Medication alternatives to Amaryl

If your healthcare provider prefers to put you on another treatment altogether, they may suggest diabetes medications in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Amaryl prescription FAQs

  • How much does Amaryl cost?

    Depending on your pharmacy, Amaryl costs around $150 for one hundred 1 mg tablets without insurance. Fortunately, generic brands, such as glimepiride, may offer an affordable alternative. Price varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • What is the best time to take Amaryl?

    You should take your Amaryl dose with breakfast or your first substantial meal of the day. It's best to take Amaryl tablets at the same time each day.

  • How can I refill my Amaryl prescription?

    Amaryl is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • How many Amaryl can you take in a day?

    The initial dose for adults is 1–2 mg once a day. Your doctor may adjust your dose until your blood sugar is controlled. Always take your medication as directed by your healthcare professional.

  • Is Amaryl hard on kidneys?

    No, Amaryl doesn't harm your kidneys. However, if you have kidney disease, Amaryl may increase your risk of severe low blood sugar.

  • Who should not take Amaryl?

    You shouldn't take Amaryl for blood sugar control if you have certain medical conditions, such as:

    • Allergic reactions to sulfonylureas

    • Type 1 diabetes

    • Diabetic ketoacidosis

    To make sure Amaryl is safe for you, talk to your doctor if you have a history of:

    • Heart disease

    • Kidney or liver disease

    • Enzyme deficiency (glucose-6-phosphate dehydrogenase deficiency (G6PD))

  • What happens if I miss a dose of Amaryl?

    If you miss a dose of Amaryl, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Amaryl?

    If you've taken too much Amaryl, call your doctor immediately or contact your local poison control center. If you experience any symptoms of low blood sugar, drink fruit juice, honey, or non-diet soda.

3 simple steps to request your Amaryl prescription today 

Step 1: Book an appointment

Step 1

Book an Amaryl prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Amaryl prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Amaryl prescription.

We can send prescriptions to any local pharmacy.

Amaryl prescription pricing details

How pricing works

To get a new or refill on your Amaryl prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Amaryl prescription resources


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.