- Chronic Care
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Glyxambi
Glyxambi (Empagliflozin/Linagliptin) prescription available
If you are suffering from type 2 diabetes mellitus, Glyxambi can help. Get a new prescription or refill of Glyxambi today from a board-certified doctor online.*
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Treat type 2 diabetes mellitus in adults
Recommended to take at the same time each day
Not effective in treating type 1 diabetes mellitus
*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.
About Glyxambi
Glyxambi is a combination of empagliflozin and linagliptin, which are oral diabetes medications that help control blood sugar. Empagliflozin helps the kidneys get rid of glucose from your bloodstream, while linagliptin regulates insulin produced by your body after eating.
Glyxambi is used to treat type 2 diabetes mellitus. It can also lower the risk of cardiovascular death from heart attack, stroke, or heart failure in adults with type 2 diabetes and established cardiovascular disease. Glyxambi is available only by prescription. It is available in a generic formulation as well as under different brand names, including empagliflozin and linagliptin.
Glyxambi may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.
If you're prescribed Glyxambi, be sure to complete the full course of the diabetes treatment unless your doctor specifically tells you to stop. If you don’t complete your prescription, the diabetes treatment may not fully treat your type 2 diabetes mellitus.
Glyxambi uses
There are several FDA-approved uses for Glyxambi, but it may also be used off-label to treat other conditions. Your online healthcare professional may prescribe it for any of the following common reasons.
It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.
Type 2 diabetes mellitus
Glyxambi is FDA-approved to improve glycemic control in adults with type 2 diabetes when treatment with both empagliflozin and linagliptin is appropriate. Glyxambi should be part of a comprehensive treatment plan that also includes diet and exercise.
Glyxambi can also help lower the risk of cardiovascular death from heart attack, stroke, or heart failure in adults with type 2 diabetes and established cardiovascular disease.
Glyxambi is not effective in treating type 1 diabetes mellitus or diabetic ketoacidosis.
Glyxambi side effects
The side effects associated with taking Glyxambi are typically mild. Most Glyxambi side effects are associated with urinary tract infections. Glyxambi has some common side effects. They may include:
Upper respiratory tract infections (sore throat, sneezing, runny nose)
Other side effects, which are less common but might be more severe, could include:Dehydration
Fast heartbeat
Rapid breathing
Tell your doctor if you notice any adverse effects or develop any other new or concerning symptoms. Glyxambi (empagliflozin/linagliptin) is not approved for blood sugar control in children under 18.
How to take Glyxambi
Your pharmacist will provide you with instructions on how to take your Glyxambi prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.
Glyxambi can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The typical starting dose of Glyxambi is 10 mg empagliflozin/5 mg linagliptin taken once daily in the morning, with or without food. If additional blood sugar control is needed, the dose may be increased to 25 mg empagliflozin/5 mg linagliptin taken once daily.
Your doctor will regularly monitor your blood sugar levels to ensure Glyxambi is safe. Be careful when getting up from a sitting or lying position or you may feel dizzy.
What to avoid while taking Glyxambi
Glyxambi has 432 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other drugs or supplements, as well as over-the-counter medicines.
Possible drug interactions with Glyxambi include:
Insulin or other oral diabetes medicine
Rifampin
Drinking alcohol while taking Glyxambi can increase the risk of low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia), depending on how much you drink. Talk to your doctor before you drink alcohol.
Medication alternatives to Glyxambi
If your healthcare provider prefers to put you on another treatment, they may suggest another diabetes medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:
Type 2 diabetes mellitus
Invokamet (canagliflozin and metformin)Synjardy (empagliflozin and metformin)
Xigduo XR (dapagliflozin and extended-release metformin)
Glyxambi prescription FAQs
How much does Glyxambi cost?
Depending on your pharmacy, Glyxambi costs around $610 for thirty 10 mg/5 mg tablets without insurance. Fortunately, generic brands, such as empagliflozin and linagliptin, offer an affordable alternative.
How can I refill my Glyxambi prescription?
To refill your Glyxambi prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your medical history, your doctor can send an electronic prescription to your local pharmacy.
Who should not take Glyxambi?
Avoid taking Glyxambi if you have certain medical conditions, such as:
Serious allergic reaction to empagliflozin or linagliptin
Diabetic ketoacidosis or type 1 diabetes
Severe kidney problems, such as end-stage renal disease
Bladder infection or urination problems
Heart failure
If you're on a low-salt diet
What is the best time to take Glyxambi?
The best time to take Glyxambi is in the morning, with or without food. However, you can safely take Glyxambi at any time of the day.
Does Glyxambi cause kidney damage?
In rare cases, Glyxambi can cause kidney problems. Kidney damage is more likely to occur if you already have kidney problems, heart failure, or take certain medications for blood pressure.
Can you take Glyxambi at night?
Glyxambi can be taken at any time of the day, with or without food. Make sure to take Glyxambi at the same time each day.
What happens if I miss a dose of Glyxambi?
If you miss a dose of Glyxambi, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.
What happens if I take too much Glyxambi?
If you've taken too much Glyxambi, seek emergency medical attention or contact your local poison control center.
3 simple steps to request your Glyxambi prescription today
Step 1
Book a Glyxambi prescription request appointment.
Book a same day appointment from anywhere.
Step 2
Talk to your medical provider regarding your Glyxambi prescription.
Visit with a doctor on your smartphone or computer.
Step 3
Pick up your Glyxambi prescription.
We can send prescriptions to any local pharmacy.
Glyxambi prescription pricing details
How pricing works
To get a new or refill on your Glyxambi prescription, join our monthly membership and get discounted visits.
Paying with insurance
Membership
$16.99/month
First month free
Visits
Copay
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price with insurance
Often the same as an office visit. Most patients with in-network insurance pay $30 or less!
- We accept these insurance plans and many more:
Paying without insurance
Membership
$16.99/month
First month free
Visits
$129
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price without insurance
Initial visits are $129.
If we're unable to treat you, we'll provide a full refund.
Glyxambi prescription resources
Sources:
PlushCare is dedicated to providing you with accurate and trustworthy health information.
Food and Drug Administration. Glyxambi empagliflozin/linagliptin prescription label. Accessed on October 25, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/206073s022lbl.pdf
Mayo Clinic. Empagliflozin And Linagliptin (Oral Route). Accessed on October 25, 2022. https://www.mayoclinic.org/drugs-supplements/empagliflozin-and-linagliptin-oral-route/description/drg-20137736
National Library of Medicine. Glyxambi (Empagliflozin/Linagliptin): A Dual-Acting Oral Medication Approved for the Treatment of Patients with Type 2 Diabetes. Accessed on October 25, 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665058/
PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.