Insulin is the hormone we all make that regulates blood sugar. In diabetes, our bodies either do not produce insulin (type 1) or become resistant to our body’s levels of insulin (type 2). Injected insulin is necessary to treat type 1 (T1DM) and may be needed to treat type 2 diabetes (T2DM), but they’re also used for other conditions. There are 3 main types of prescription insulin.
Insulin is a hormone made by the beta cells in your pancreas. It takes glucose from carbohydrates consumed and converts it to the energy that your body uses right away or stores for later use.
It helps stabilize your blood sugar levels and keeps them from going too low (hypoglycemia) or too high (hyperglycemia).
Even though your body needs sugar for energy, the sugar usually can’t get into your cells directly. You need insulin to signal cells to soak up the sugar from your bloodstream. This process allows the sugar to enter your cells and be used for energy.
If your body absorbs more sugar than it needs, this hormone will signal it to be stored in your muscles and liver and ready for release if your blood sugar levels get too low. In other words, it helps your body balance your blood sugar levels and keeps them within normal range.
If your body can’t produce enough of this hormone, cells become resistant to how it should normally work, you can develop hyperglycemia. This can cause complications like diabetes if your blood sugar levels stay too high for too long.
What insulin treats
The most common condition treated with human insulin is diabetes. The drugs are designed to replace or supplement the body’s natural hormones.
These medicines allow blood glucose to enter cells and enable the body to store blood sugar more adequately for later use. This helps address a significant problem in people with diabetes mellitus: high blood sugar.
Other conditions are also treated with this therapy. Mild-to-moderate diabetic ketoacidosis, for example, may need management with this approach. Learn more about this and other off-label uses of this therapy below.
Diabetic ketoacidosis
Diabetic ketoacidosis is a serious and potentially life-threatening complication of diabetes. It is most common in people with T1DM, but people with T2DM can also develop it. Diabetic ketoacidosis occurs when the body doesn’t have sufficient amounts of insulin to encourage blood sugar into the cells for use as energy.
The injections can reverse ketoacidosis and are essential for successfully managing this complication. In this case, the hormone promotes glucose use by peripheral tissues and helps your body regulate energy use back to a safe level.
Gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a condition wherein a hormone made by the placenta prevents the body from using insulin properly. It develops during pregnancy. Instead of being absorbed by the cells, glucose accumulates in the blood.
What makes GDM different than T1DM is that it’s not the lack of the hormone that causes the problem but other hormones that decrease its effectiveness. Some, but not all, pregnant women need human insulin to treat GDM. The role of this therapy is to lower blood sugar levels.
Hyperosmolar hyperglycemic state
Hyperosmolar hyperglycemic state affects people with T2DM whose blood sugar levels are severe or abnormally high (sometimes over 40mmol/l). This state may develop over a few weeks or result from other problems, such as dehydration. It requires emergency medical service, i.e., immediate help.
This therapy can help with the mild-to-moderate hyperosmolar hyperglycemic state. The first line of treatment in the emergency room is aggressive fluid management, after which patients receive insulin to help lower blood sugar.