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Chronic Care Diabetes Xigduo XR
Chronic Care Diabetes Xigduo XR

Xigduo XR (dapagliflozin/metformin) prescription available online

If you are suffering from type 2 diabetes mellitus, Xigduo XR can help. Get a new prescription or refill of Xigduo XR from a board-certified doctor online.*

Treats type 2 diabetes mellitus in adults Available as an extended-release tablet Most effective in combination with diet and exercise
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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.
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About Xigduo XR (dapagliflozin/metformin)

Xigduo XR is an oral diabetes medication. Xigduo extended-release tablets contain a combination of dapagliflozin and metformin, which help control blood sugar levels by getting rid of excess glucose and lowering glucose production in the liver.

 

Xigduo XR is used to treat type 2 diabetes mellitus. It also helps lower the risk of hospitalization for heart failure in adults with type 2 diabetes, heart disease, and chronic kidney disease. Xigduo XR is available only by prescription. It is available in a generic formulation under different brand names, including dapagliflozin/metformin.

 

Xigduo XR may be prescribed as an extended-release tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

 

If you're prescribed Xigduo XR, complete the entire course of the oral diabetes medication unless your doctor specifically tells you to stop. If you don’t complete your prescription, the diabetes medication may not fully treat your type 2 diabetes mellitus.

Xigduo XR (dapagliflozin / metformin) uses

There are several FDA-approved uses for Xigduo XR, but your healthcare provider may also prescribe it off-label to treat other medical conditions.

 

Your PlushCare doctor may prescribe Xigduo XR for the following reasons or other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

Type 2 diabetes mellitus

Xigduo XR is used to treat type 2 diabetes mellitus in adults in combination with diet and exercise. Dapagliflozin helps the kidneys eliminate excess glucose from the bloodstream, while metformin lowers glucose production in the liver.

 

Xigduo XR is also used to lower the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and heart disease. It also reduces the risk of worsening kidney disease and death due to heart failure in adults with type 2 diabetes mellitus and chronic kidney disease.

 

Xigduo XR is not suitable for adults with type 1 diabetes mellitus or diabetic ketoacidosis.

Xigduo XR side effects

The side effects associated with taking Xigduo XR are typically mild. Most Xigduo XR side effects are associated with gastrointestinal discomfort. Xigduo XR has some common side effects. They may include:

  • Nausea, vomiting, or diarrhea

  • Yeast infections and urinary tract infections (UTIs)

  • Headache


Other side effects, which are less common but might be more severe, could include:

  • Little or no urination

  • Dehydration symptoms

  • Lactic acidosis (stomach pain, trouble breathing, unusual muscle pain, feeling unusual weakness or tiredness)


You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Be sure to tell your doctor if any lactic acidosis symptoms occur.

The use of Xigduo XR is not approved for children under 18 years old.

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How to take Xigduo XR

Your pharmacist will provide you with instructions on how to take your Xigduo XR prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

 

Xigduo XR can come in different forms and doses, so be sure to follow the specific instructions on your prescription. When initiating Xigduo XR therapy, your starting dose will depend on your treatment plan. Your maximum dose should not exceed dapagliflozin 10 mg and metformin 2000 mg per day.

 

Xigduo XR is typically used with diet, exercise, and regular blood sugar testing to control blood glucose levels.

What to avoid while taking Xigduo XR

Xigduo XR has 447 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

Possible drug interactions with Xigduo XR include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

  • Lanoxin (digoxin)

  • Rifampin

  • Phenytoin

  • Diuretics ("water pills")

  • Insulin and other diabetes medications

 

Drinking alcohol may affect blood sugar, leading to low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia), depending on how much you drink. Xigduo XR-treated patients should avoid drinking alcohol.

Medication alternatives to Xigduo XR

Xigduo XR is a combination medication containing two active ingredients, dapagliflozin and metformin. If you cannot take Xigduo XR, several other medications may be used as alternatives. Here are a few examples:

Type 2 diabetes mellitus

Jardiance (empagliflozin) Rybelsus® Glucotrol (glipizide)

Xigduo XR prescription FAQs

How much does Xigduo XR cost?

Depending on your pharmacy, Xigduo XR costs around $587 for thirty 10 mg-500 mg tablets without insurance. Fortunately, generic brands, such as dapagliflozin/metformin, offer an affordable alternative.

How can I refill my Xigduo XR prescription?

To refill your Xigduo XR prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy.

Who should not take Xigduo XR?

Avoid taking Xigduo XR if you have certain medical conditions, such as:

  • Severe kidney disease

  • Severe metabolic acidosis or diabetic ketoacidosis

  • Low blood pressure

  • Pancreatic insulin deficiency

  • Severe renal impairment

What is Xigduo XR used for?

Xigduo XR is used in combination with diet and exercise to improve blood glucose control in adults with type 2 diabetes mellitus.

What is the best time to take Xigduo XR?

Xigduo XR should be taken with or immediately after food in the evening. Take Xigduo XR at the same time each day.

Can you take Xigduo on an empty stomach?

No, you should not take Xigduo XR on an empty stomach. Take Xigduo XR with a meal unless otherwise directed.

What happens if I miss a dose of Xigduo XR?

If you miss a dose of Xigduo XR, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

What happens if I take too much Xigduo XR?

If you've taken too much Xigduo XR, seek medical help or contact your local poison control center. You may experience severe hypoglycemia (low blood sugar).

3 simple steps to request your Xigduo XR prescription today

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Step 1

Book a Xigduo XR prescription request appointment.

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Step 2

Talk to your medical provider regarding your Xigduo XR prescription.

Visit with a doctor on your smartphone or computer.
How It Works Step 3
Step 3

Pick up your Xigduo XR prescription.

We can send prescriptions to any local pharmacy.

Xigduo XR prescription pricing details

To get a new or refill on your Xigduo XR prescription, join our monthly membership and get discounted visits.

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  • Prescription discount card to save up to 80%
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*If we're unable to treat you, we'll provide a full refund. Please note that any medication or lab work costs are not included. Please refer to our refund policy for additional information.

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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.