Ziac (hydrochlorothiazide/bisoprolol) prescription available online 

If you are suffering from high blood pressure, Ziac can help. Get a new prescription or refill of Ziac from a board-certified doctor online.*

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FDA-approved to treat high blood pressure

Available as a tablet

Request Ziac in as little as 15 minutes, with or without insurance*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Ziac (hydrochlorothiazide/bisoprolol)

Ziac is a combination of hydrochlorothiazide and bisoprolol. Hydrochlorothiazide is a diuretic (water pill), which increases urination. Bisoprolol is a beta-blocker, which blocks the effects of certain chemicals on the heart and blood vessels.

Ziac is used to treat high blood pressure. Ziac is available only by prescription. It is available in a generic formulation as hydrochlorothiazide and bisoprolol.

Ziac may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Ziac, be sure to complete the full course of the combination therapy unless your doctor specifically tells you to stop. If you don’t complete your prescription, the medication may not fully treat your high blood pressure.

Ziac uses

There is one FDA-approved use for Ziac, but your healthcare provider may also prescribe it off-label to treat other medical conditions.

Your doctor may prescribe Ziac for any of the following reasons, or other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • High blood pressure

    Ziac is FDA-approved to treat high blood pressure. Hydrochlorothiazide helps the body get rid of excess salt and water, which helps relax blood vessels and improve blood flow. Bisoprolol slows your heartbeat, lowers blood pressure, and reduces strain on the heart.

Ziac side effects

  • The side effects of Ziac are typically mild. Most Ziac side effects are associated with dizziness.

    Ziac has some common side effects. They may include:

    • Dizziness and lightheadedness

    • Feeling weak or tired

    • Diarrhea, nausea, or indigestion

    Other side effects, which are less common but might be more severe, could include:

    • Allergic reactions

    • Fast, slow, or uneven heartbeat

    • Chest pain

    • Low blood sugar

    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. The use of Ziac is not recommended for children under 18.

How to take Ziac

Your pharmacist will provide you with instructions on how to take your Ziac prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Ziac can come in different doses, so be sure to follow the specific instructions on your prescription. The initial Ziac dosage for adults is bisoprolol 2.5 mg-hydrochlorothiazide 6.25 mg orally once a day.

What to avoid while taking Ziac

Ziac has 587 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications, supplements, and other drugs.

Possible drug interactions with Ziac include:

  • Insulin or oral diabetes medication

  • Lithium

  • Sedatives or narcotic medicine

  • Other heart or blood pressure medicine

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

  • Steroid medicine

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly to prevent a fall.

Ziac can increase your sensitivity to the sun. Wear protective clothing and sunscreen when outdoors.

Because alcohol can lower blood pressure, drinking alcohol while taking Ziac may lead to an increased risk of adverse reactions. Talk to your doctor before drinking alcohol.

Medication alternatives to Ziac

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other beta-blockers or diuretics another drug class. Here are some common doctor-recommended alternatives based on your condition:

Ziac prescription FAQs

  • How much does Ziac cost?

    Depending on your pharmacy, Ziac costs around $270 for thirty 10 mg-6.25 mg tablets without insurance. Fortunately, generic brands, such as hydrochlorothiazide and bisoprolol, may offer an affordable alternative. Price varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my Ziac prescription?

    To refill your Ziac prescription, book a virtual appointment with one of our board-certified doctors. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy, if you qualify.

  • Who should not take Ziac?

    Avoid taking Ziac if you have certain medical conditions, such as:

    • Congestive heart failure or coronary artery disease

    • Sick sinus syndrome or AV block

    • Peripheral vascular disease

    • Allergic reaction to sulfa drugs

    • Kidney or liver disease

    • Thyroid disorder

    • Asthma or other breathing disorder

    • Impaired renal function

  • Does Ziac lower heart rate? 

    Yes, Ziac can lower heart rate. Bisoprolol, one of the active ingredients, is a beta-blocker that blocks the effects of certain chemicals on the heart and blood vessels, which lowers heart rate.

  • Is Ziac good for blood pressure?

    Yes, Ziac is an effective medication to lower blood pressure. It combines two medications, a beta-blocker and a diuretic (water pill), into a single pill for convenience.

  • Can Ziac raise blood sugar?

    Yes, Ziac can raise blood sugar. Talk to your doctor before you begin combination therapy if you have diabetes.

  • What happens if I miss a dose of Ziac?

    If you miss a dose of Ziac, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Ziac?

    If you've taken too much Ziac, seek emergency medical attention or contact your local poison control center.

3 simple steps to request your Ziac prescription today 

Step 1: Book an appointment

Step 1

Book a Ziac prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Ziac prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Ziac prescription.

We can send prescriptions to any local pharmacy.

Ziac prescription pricing details

How pricing works

To get a new or refill on your Ziac prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.