Ziac (Hydrochlorothiazide / Bisoprolol) Prescriptions Available Online Today

Our doctors are here to help. Ziac can treat high blood pressure and more. Speak to one of our board-certified doctors to see if Ziac is right for you.

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Our online doctors have treated over 415,000 patients.

An doctor at PlushCare can help you request a prescription online from your phone.

Can You Get Ziac (Hydrochlorothiazide / Bisoprolol) Online?

Yes, licensed medical doctors can prescribe Ziac (Hydrochlorothiazide Bisoprolol) online after a medical evaluation.

You can speak with one of our online doctors to learn more about Ziac. Book an online appointment with one of our top doctors using your phone or computer.

During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for Ziac, they can write a prescription and electronically send it to a nearby pharmacy for pickup.

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What Is Ziac?

Ziac is a combination medication for the treatment of high blood pressure. It combines hydrochlorothiazide (a water pill that prevents your body from retaining too much salt) with bisoprolol (a beta-blocker that improves blood flow through arteries and veins). This combination helps lower blood pressure with one pill instead of two.

1. Book

Visit with a doctor on your smartphone or computer.

2. Chat

Visit with a doctor on your smartphone or computer.

3. Pick up

We can send prescriptions to any local pharmacy or by mail.

How Does Ziac Work?

Ziac works in two ways. It helps your kidneys flush out more salt and water, which reduces edema (fluid retention) that can be caused by high blood pressure. It also prevents certain chemicals in your body (like adrenaline) from working on your heart and blood vessels, which help lower high blood pressure.

Ziac Dosage and Treatment

The starting dose of Ziac is usually one tablet per day that contains 2.5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide. Dosages may go as high as one tablet daily that has 20 mg of bisoprolol and 12.5 mg of hydrochlorothiazide. You should always follow the dosage prescribed by your doctor and written on your medication.

Benefits of Ziac

Ziac has two primary benefits: it reduces fluid retention (edema) and lowers blood pressure. Fluid retention can cause swollen, painful hands, feet, or legs. Ziac also lowers blood pressure. High blood pressure can lead to stroke, kidney problems, or heart attack. Ziac is a combination pill and allows you to take one pill instead of two for these conditions.

Side Effects of Ziac

As with any medication, Ziac has been determined to be generally safe. However, it does carry a risk of side effects. Some side effects you may experience on Ziac include:

  • Headache
  • Upset stomach
  • Lightheadedness
  • Nausea
  • Fatigue
  • Dizziness
  • Constipation
  • Diarrhea
  • Cough
  • Drowsiness
  • Low blood sugar
  • Low blood pressure
  • Low potassium
  • Trouble sleeping
  • Reduced heart rate
  • Increased blood glucose
  • Cold feet or hands
  • Impotence
  • Dehydration
  • Heart block
  • Congestive heart failure
  • Abnormal heart rhythms
  • Severely reduced heart rate
  • Bronchospasms
  • Serious skin reactions

Considerations and Precautions of Ziac

While Ziac is generally considered safe, it isn’t right for everybody. Always tell your doctor about your current medications and medical history to prevent potentially serious complications.

Always be sure to tell your doctor your full medical history. Ziac may cause complications with certain medical conditions. Especially be sure to mention if you have or have had any of the following:

  • Heartbeats slow enough to make you faint
  • Uncontrolled or severe heart failure
  • Inability to urinate
  • Serious heart condition
  • Asthma or other breathing disorder
  • Diabetes
  • Glaucoma
  • Thyroid problems
  • Liver disease
  • Kidney disease
  • Peripheral vascular disease
  • Gout
  • Lupus
  • Allergy to penicillin or sulfa drugs

Ziac Interactions

Ziac may cause serious interactions with certain medications. This may mean that you shouldn’t take Ziac, or your doctor may choose to adjust the dosage of one or both of the medications. Always tell your doctor about every medication you take, including vitamins, supplements, and over the counter drugs. Especially be sure to mention if you take any of the following:

  • Rifampin
  • Calcium channel blockers (CCBs) like diltiazem (Cardizem, Tiazac) and verapamil (Calan, Isoptin)
  • Digoxin (Lanoxin)
  • Lithium
  • Corticosteroids
  • Cholestyramine (Questran)
  • Colestipol (Colestid)
  • NSAIDs like naproxen (Aleve) or ibuprofen [Advil, Motrin)

Can You Buy Ziac Online?

Yes you can buy Ziac online. Book an appointment online with one of PlushCare’s licensed doctors, who can electronically send a prescription to your trusted pharmacy if they determine it’s right for you.

When you book your appointment, you will input all your medications and medical history. That helps your doctor better understand your condition. Next, you will talk to one of our trusted doctors. If they decide that Ziac is right for you, or that you would benefit from a different medication, they will electronically send the prescription to the pharmacy of your choice, where you can pick it up as soon as it’s ready.


Telehealth is not appropriate for serious conditions that require immediate attention or emergency care. If you experience any life-threatening issues, call 911 or go to an emergency room immediately.


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