Ziac (Hydrochlorothiazide / Bisoprolol) Prescriptions Available Online Today
Our doctors are here to help. Ziac can treat high blood pressure and more. Speak to one of our board-certified doctors to see if Ziac is right for you.
Book an appointmentOur doctors are here to help. Ziac can treat high blood pressure and more. Speak to one of our board-certified doctors to see if Ziac is right for you.
Medication services available for adults and kids (3+)
Top quality, board-certified doctors
No insurance required
Same-day prescriptions available*
* Prescriptions provided at doctor’s discretion.
We accept these insurance plans and many more!
Most patients with in-network insurance pay $30 or less. Otherwise, new patient visits are $129, and follow-ups are only $69 for members.
Don’t see your provider listed? Email [email protected] or call (888) 564-4454 to talk to a PlushCare specialist.
3 simple steps to request your prescription online today

Step 1
Book
Visit with a doctor on your smartphone or computer.

Step 2
Chat
Visit with a doctor on your smartphone or computer.

Step 3
Pick up
We can send prescriptions to any local pharmacy.
Can You Get Ziac (Hydrochlorothiazide / Bisoprolol) Online?
Yes, licensed medical doctors can prescribe Ziac (Hydrochlorothiazide Bisoprolol) online after a medical evaluation.
You can speak with one of our online doctors to learn more about Ziac. Book an online appointment with one of our top doctors using your phone or computer.
During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for Ziac, they can write a prescription and electronically send it to a nearby pharmacy for pickup.
What Is Ziac?
Ziac is a combination medication for the treatment of high blood pressure. It combines hydrochlorothiazide (a water pill that prevents your body from retaining too much salt) with bisoprolol (a beta-blocker that improves blood flow through arteries and veins). This combination helps lower blood pressure with one pill instead of two.
Ziac prescription FAQs
How Does Ziac Work?
Ziac works in two ways. It helps your kidneys flush out more salt and water, which reduces edema (fluid retention) that can be caused by high blood pressure. It also prevents certain chemicals in your body (like adrenaline) from working on your heart and blood vessels, which help lower high blood pressure.
Ziac Dosage and Treatment
The starting dose of Ziac is usually one tablet per day that contains 2.5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide. Dosages may go as high as one tablet daily that has 20 mg of bisoprolol and 12.5 mg of hydrochlorothiazide. You should always follow the dosage prescribed by your doctor and written on your medication.
Benefits of Ziac
Ziac has two primary benefits: it reduces fluid retention (edema) and lowers blood pressure. Fluid retention can cause swollen, painful hands, feet, or legs. Ziac also lowers blood pressure. High blood pressure can lead to stroke, kidney problems, or heart attack. Ziac is a combination pill and allows you to take one pill instead of two for these conditions.
Side Effects of Ziac
As with any medication, Ziac has been determined to be generally safe. However, it does carry a risk of side effects. Some side effects you may experience on Ziac include:
Upset stomach
Lightheadedness
Nausea
Fatigue
Dizziness
Constipation
Diarrhea
Cough
Drowsiness
Low blood sugar
Low blood pressure
Low potassium
Trouble sleeping
Reduced heart rate
Increased blood glucose
Cold feet or hands
Dehydration
Heart block
Congestive heart failure
Abnormal heart rhythms
Severely reduced heart rate
Bronchospasms
Serious skin reactions
Considerations and Precautions of Ziac
While Ziac is generally considered safe, it isn’t right for everybody. Always tell your doctor about your current medications and medical history to prevent potentially serious complications.
Always be sure to tell your doctor your full medical history. Ziac may cause complications with certain medical conditions. Especially be sure to mention if you have or have had any of the following:
Heartbeats slow enough to make you faint
Uncontrolled or severe heart failure
Inability to urinate
Serious heart condition
Asthma or other breathing disorder
Glaucoma
Liver disease
Kidney disease
Peripheral vascular disease
Lupus
Allergy to penicillin or sulfa drugs
Ziac Interactions
Ziac may cause serious interactions with certain medications. This may mean that you shouldn’t take Ziac, or your doctor may choose to adjust the dosage of one or both of the medications. Always tell your doctor about every medication you take, including vitamins, supplements, and over the counter drugs. Especially be sure to mention if you take any of the following:
Rifampin
Calcium channel blockers (CCBs) like diltiazem (Cardizem, Tiazac) and verapamil (Calan, Isoptin)
Digoxin (Lanoxin)
Lithium
Corticosteroids
Cholestyramine (Questran)
Colestipol (Colestid)
NSAIDs like naproxen (Aleve) or ibuprofen [Advil, Motrin)
Can You Buy Ziac Online?
Yes you can buy Ziac online. Book an appointment online with one of PlushCare's licensed doctors, who can electronically send a prescription to your trusted pharmacy if they determine it’s right for you.
When you book your appointment, you will input all your medications and medical history. That helps your doctor better understand your condition. Next, you will talk to one of our trusted doctors. If they decide that Ziac is right for you, or that you would benefit from a different medication, they will electronically send the prescription to the pharmacy of your choice, where you can pick it up as soon as it’s ready.