HydroDiuril (hydrochlorothiazide) prescription available online

If you are suffering from high blood pressure or edema, HydroDiuril (hydrochlorothiazide) can help. Get a new prescription or refill of HydroDiuril from a board-certified doctor online.*

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FDA-approved to treat hypertension and edema

Help prevent heart attacks and strokes

Reduces extra fluid in the body

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About HydroDiuril (hydrochlorothiazide) 

HydroDiuril is considered a diuretic, which helps the body get rid of excess salt and water. Like other water pills, hydrodiuril also reduces extra fluid in the body.

Some conditions that HydroDiuril is known to treat include high blood pressure, fluid retention (edema), and urinary calcium excretion. Hydrodiuril is available only by prescription. It is available in a generic formulation as hydrochlorothiazide, as well as under different brand names.

HydroDiuril may be prescribed as as a tablet, capsule, or oral suspension. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage.

If you are prescribed HydroDiuril, be sure to complete the full course of the diuretic therapy unless your doctor directs you to stop. If you don’t complete your prescription, the diuretic may not fully treat your high blood pressure or fluid retention.

HydroDiuril uses

There are several FDA-approved uses for HydroDiuril, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your health care provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online physician or pharmacist.

  • High blood pressure (hypertension)

    HydroDiuril is FDA-approved to treat hypertension, which can help prevent heart attacks, strokes, and kidney problems.

  • Edema (fluid retention)

    HydroDiuril is FDA-approved to treat edema caused by congestive heart failure, cirrhosis of the liver, or kidney disorders. It can also be used to treat edema caused by taking steroids or estrogen.

HydroDiuril side effects

  • The side effects associated with taking HydroDiuril are typically mild. Most HydroDiuril side effects are associated with gastrointestinal discomfort. Common side effects of HydroDiuril may include:

    • Pain or discomfort in your upper stomach

    • Tiredness

    • Feeling like you might pass out

    Other side effects, which are less common but might be more severe, could include:

    • Dehydration

    • Pale skin, easy bruising, or unusual bleeding

    • Shortness of breath

    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. The use of HydroDiuril is not recommended in children under 1.

How to take HydroDiuril

Your pharmacist will provide you with instructions on how to take your HydroDiuril prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

HydroDiuril can come in different forms and doses, so be sure to follow the specific instructions on your prescription.

Follow your doctor’s directions about how to take HydroDiuril. The dosage of HydroDiuril (hydrochlorothiazide) can range from 25 mg to 100 mg daily, taken once or in divided doses. Your doctor may also advise you to take HydroDiuril as infrequently as once a week depending on your medical history.

What to avoid while taking HydroDiuril

Hydrodiuril has 446 drug interactions. Do not change what you are taking without checking with your doctor or pharmacist. That includes other prescription medication or supplements, as well as over-the-counter drugs.

Possible drug interactions with HydroDiuril include:

  • Nonsteroidal anti-inflammatory drugs, such as naproxen (Aleve) and ibuprofen (Motrin, Advil)

  • Insulin or other drugs for diabetes mellitus

  • Other blood pressure medications

  • Lithium

  • Steroid medications

Please note that this is not a complete list of possible drug interactions.

Alcohol may have additive effects in lowering your blood pressure, which can lead to dizziness, lightheadedness, and fainting. Avoid drinking alcohol while taking HydroDiuril.

Medication alternatives to HydroDiuril

If your physician prefers to put you on another treatment altogether, they may suggest other thiazide diuretics or antihypertensives in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

HydroDiuril prescription FAQs

  • How much does HydroDiuril cost?

    Depending on your pharmacy, HydroDiuril costs around $13 for thirty 12.5 mg capsules. Generic brands, such as hydrochlorothiazide, might offer a more affordable alternative. Price may also vary with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my HydroDiuril prescription?

    To refill your HydroDiuril prescription, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your doctor will send your prescription to your local pharmacy for pickup.

  • Who should not take HydroDiuril?

    To make sure HydroDiuril is safe for you, tell your doctor if you have:

    • Diabetes mellitus

    • Asthma

    • Electrolyte imbalance

    • Kidney or liver disease

    • Low blood pressure

    • Acute transient myopia

    • Glucose intolerance

  • What happens if I miss a dose of HydroDiuril?

    If you miss a dose of HydroDiuril, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much HydroDiuril?

    If you've taken too much HydroDiuril, seek emergency medical attention or contact your local poison control center.

  • What are the benefits of HydroDiuril?

    HydroDiuril helps lower blood pressure and relieve swelling caused by problems with the liver, kidneys, or heart. HydroDiuril also helps reduce your risk having a stroke or heart attack by lowering blood pressure.

3 simple steps to request your HydroDiuril prescription today 

Step 1

Book a HydroDiuril prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your HydroDiuril prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your HydroDiuril prescription.

We can send prescriptions to any local pharmacy.

HydroDiuril prescription pricing details

How pricing works

To get a new or refill on your HydroDiuril prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.