Zaroxolyn (metolazone) prescription available online

If you are suffering from high blood pressure or edema, Zaroxolyn can help. Get a new prescription or refill of Zaroxolyn from a board-certified doctor online.*

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Aids in eliminating excess water from the body

Treats high blood pressure and fluid retention

Multiple FDA-approved uses

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Zaroxolyn (metolazone)

Zaroxolyn is a diuretic (water pill) that increases urination, which helps the body get rid of excess water. Zaroxolyn is used to treat high blood pressure and fluid retention (edema) associated with congestive heart failure or kidney disease.

Zaroxolyn is available only by prescription. It is available in a generic formulation as well as under different brand names, including metolazone.

Zaroxolyn may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Zaroxolyn, be sure to complete the full course of the diuretic unless your doctor specifically tells you to stop. If you don’t complete your prescription, the water pill may not fully treat your high blood pressure or fluid retention.

Zaroxolyn uses

There are several FDA-approved uses for Zaroxolyn, but your physician may also prescribe it off-label to treat other medical conditions.

Your doctor may prescribe Zaroxolyn for any of the following reasons, or other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • High blood pressure

    Zaroxolyn is FDA-approved to treat high blood pressure alone or with other antihypertensive drugs. Lowering blood pressure can help reduce the risk of strokes, heart attacks, and kidney problems.

  • Edema (fluid retention)

    Zaroxolyn is FDA-approved to treat fluid retention associated with congestive heart failure or renal disease, including a kidney disorder known as nephrotic syndrome.

Zaroxolyn side effects

The side effects associated with taking Zaroxolyn are typically mild. Most Zaroxolyn side effects are associated with dizziness or tiredness.

  • Zaroxolyn has some common side effects. They may include:

    • Dizziness or spinning sensation

    • Drowsiness

    • Joint or muscle pain

    Other side effects, which are less common but might be more severe, could include:

    • Chest pain

    • Irregular heartbeats

    • Easy bruising or bleeding

    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. The use of Zaroxolyn is not recommended in children under 18.

How to take Zaroxolyn

Your pharmacist will provide you with instructions on how to take your Zaroxolyn prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Zaroxolyn can come in different doses, so be sure to follow the specific instructions on your prescription. The starting dose of Zaroxolyn can range from 5 mg to 20 mg once daily for edema, while starting doses typically range from 2.5 mg to 5 mg once daily for hypertension.

What to avoid while taking Zaroxolyn

Zaroxolyn has 424 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Zaroxolyn include:

  • Other blood pressure medicine

  • Furosemide or other diuretics

  • Insulin or oral diabetes medication

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

Because this medication can lower blood pressure, drinking alcoholic beverages can increase your risk of adverse reactions. Ask your doctor for medical advice before drinking alcohol.

Medication alternatives to Zaroxolyn

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another diuretic or an antihypertensive drug in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Zaroxolyn prescription FAQs

  • How much does Zaroxolyn cost?

    Depending on your pharmacy, Zaroxolyn costs around $65 for one hundred 2.5 mg tablets without insurance. Fortunately, generic brands, such as metolazone, may offer a more affordable alternative. Price also varies with insurance coverage. Our prescription discount card can help members save up to 80% on prescriptions.

  • How long does it take for Zaroxolyn to work?

    When taken for edema, Zaroxolyn starts working within one hour to increase urination. It can take between 3–4 days to 3–6 weeks to start treating high blood pressure.

  • Can Zaroxolyn cause dryness?

    Yes, Zaroxolyn may cause constipation, increased thirst, and dry mouth. These are normal side effects.

  • Does Zaroxolyn affect blood pressure?

    Yes, Zaroxolyn is used to treat high blood pressure. Metolazone helps the kidney get rid of excess fluid in the body to lower swelling and blood pressure.

  • How can I refill my Zaroxolyn prescription?

    To refill your Zaroxolyn prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your symptoms, your doctor can send an electronic prescription to your local pharmacy if you qualify.

  • Who should not take Zaroxolyn?

    Avoid taking metolazone if you have certain medical conditions, such as:

    • Liver disease

    • Systemic lupus erythematosus

    • Allergic reaction to sulfa drugs

    • Diabetes

    • Gout

    • Kidney disease

    Taking this medication during pregnancy can cause side effects in the newborn baby, such as blood cell problems and jaundice (yellowing of the skin or eyes). Tell your doctor if you're pregnant or become pregnant while taking Zaroxolyn.

  • What happens if I miss a dose of Zaroxolyn?

    If you miss a dose of Zaroxolyn, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Zaroxolyn?

    If you've taken too much Zaroxolyn, call your doctor immediately or contact your local poison control center. If you experience overdose symptoms, such as severe dizziness, seek emergency medical help.

3 simple steps to request your Zaroxolyn prescription today 

Step 1

Book a Zaroxolyn prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Zaroxolyn prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Zaroxolyn prescription.

We can send prescriptions to any local pharmacy.

Zaroxolyn prescription pricing details

How pricing works

To get a new or refill on your Zaroxolyn prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.