Diuril (chlorothiazide) prescription available online

If you are suffering from edema or high blood pressure, Diuril (chlorothiazide) can help. Get a new prescription or refill of Diuril from a board-certified doctor online.*

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Helps lower blood pressure and prevent fluid retention

Available as an oral suspension or intravenous injection

Several FDA-approved uses

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Diuril (chlorothiazide)

Diuril (chlorothiazide) is a type of diuretic used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or kidney disease. It's also used to treat high blood pressure.

Diuril is available only by prescription. It is available in a generic formulation as chlorothiazide.

Diuril may be prescribed as an oral suspension or intravenous injection. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Diuril, be sure to complete the full course of the diuretic unless your doctor specifically tells you to stop. If you don’t complete your prescription, the diuretic may not fully treat your edema or high blood pressure.

Diuril uses

There are several FDA-approved uses for Diuril, but your healthcare provider may also prescribe it off-label to treat other medical conditions.

Your doctor may prescribe Diuril for any of the following reasons or other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Edema

    Diuril is FDA-approved to treat edema (fluid retention) in people with congestive heart failure, liver disease, and corticosteroid and estrogen therapy. It can also help treat edema associated with kidney disease, incuding renal dysfunction, nephrotic syndrome, and chronic renal failure.

    Diuril is not recommended for edema during pregnancy, as it may cause fetal harm.

  • High blood pressure

    Diuril is FDA-approved to treat high blood pressure (hypertension) alone. Diuril can help reduce the risk of stroke, heart attack, and kidney problems.

    In patients taking other blood pressure medications, it can enhance the effectiveness of those antihypertensive drugs to treat more severe forms of high blood pressure.

Diuril side effects

The side effects associated with taking Diuril are typically mild. Most Diuril side effects are associated with dizziness.

  • Diuril has some common side effects. They may include:

    • Dizziness or spinning sensation

    • Numbness or tingling

    • Stomach and muscle cramps

    Other side effects, which are less common but might be more severe, could include:

    • Dark-colored urine

    • Allergic reaction

    • Easily bruising or bleeding

    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. Diuril may be prescribed off-label to treat chronic lung disease in pediatric patients.

How to take Diuril

Your pharmacist will provide you with instructions on how to take your Diuril prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Diuril can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The usual adult dosage is 500–1000 mg (10 mL to 20 mL) once or twice daily.

Shake the oral suspension before measuring a dose. Use the dosing syringe provided, or use a medicine dose-measuring device.

Diuril IV injection is given as an infusion. Your healthcare provider will administer the injection in a hospital setting if you cannot take the medication by mouth.

In diabetic patients, dosage adjustments of insulin may be required.

What to avoid while taking Diuril

Diuril has 419 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications, supplements, and drug therapy.

Possible drug interactions with Diuril include:

  • Other antihypertensive drugs

  • Cholestyramine or colestipol

  • Lithium

  • Insulin or oral diabetes medicine

  • Steroid medicine

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

Because alcohol can lower blood pressure, drinking alcohol while taking Diuril may increase the risk of adverse reactions. Talk to your doctor before drinking alcohol while on Diuril.

Medication alternatives to Diuril

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another diuretic therapy or blood pressure medicine in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Diuril prescription FAQs

  • How much does Diuril cost?

    Depending on your pharmacy, Diuril costs around $83 for 240 mL of oral suspension without insurance. Fortunately, generic brands, such as chlorothiazide, can offer a more affordable alternative. Price varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my Diuril prescription?

    To refill your Diuril prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your symptoms, your doctor can send an electronic prescription to your local pharmacy.

  • Does Diuril lower blood pressure?

    Yes, Diuril helps lower blood pressure. It reduces the amount of water in the body by increasing urination, which helps lower blood pressure and prevent fluid retention.

  • Does Diuril deplete potassium?

    Yes, thiazide diuretic therapy, such as Diuril, tends to deplete the body of potassium. Your doctor may encourage you to eat potassium-rich foods to prevent an electrolyte imbalance.

  • Who should not take Diuril?

    Avoid taking Diuril if you have certain medical conditions, such as:

    • Allergic reaction to sulfa drugs

    • Inability to urinate

    Tell your doctor if you've ever had:

    • Kidney disease

    • Liver disease or renal disease

    • Gout

    • Diabetes

    • High cholesterol or triglycerides

    • Cardiovascular disease

  • How long does it take Diuril to work?

    Diuril starts working around two hours after your first dose, causing an increase in urination.

  • What happens if I miss a dose of Diuril?

    If you miss a dose of Diuril, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Diuril?

    If you've taken too much Diuril, call your doctor immediately or contact your local poison control center.

3 simple steps to request your Diuril prescription today 

Step 1

Book a Diuril prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Diuril prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Diuril prescription.

We can send prescriptions to any local pharmacy.

Diuril prescription pricing details

How pricing works

To get a new or refill on your Diuril prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.