Humalog (insulin lispro) prescription available online 

If you are suffering from diabetes, Humalog can help. Get a new prescription or refill of Humalog from a board-certified doctor online.*

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Begins to take effect about 15 minutes after injection

Available as an insulin dose injection

Save up to 11% on Humalog with RX discount card*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Humalog (insulin lispro)

Humalog is a fast-acting insulin dose that starts working about 15 minutes after injection. It helps control high blood sugar levels in adults and children with type 1 or type 2 diabetes.

Humalog moves sugar from the blood into other tissues where it's used for energy. It also stops the liver from producing blood sugar and slows the liver's production of glucose.

Humalog is available only by prescription. It's available in two different forms: Humalog and Humalog Mix (combination protamine and insulin lispro). It's available in a generic formulation under the name insulin lispro.

Humalog may be prescribed as an insulin dose injection. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed insulin lispro injection (Humalog), be sure to complete the full course unless your doctor specifically tells you to stop. If you don’t complete your prescription, Humalog may not fully treat your high blood sugar levels.

Humalog uses

There are several FDA-approved uses for insulin lispro injection (Humalog), but your healthcare provider may also prescribe it off-label to treat other medical conditions.

Your doctor may prescribe Humalog for any of the following reasons, or other reasons not listed here. If you have questions about why a medication is prescribed, talk with your doctor or pharmacist.

  • Diabetes mellitus

    Humalog is FDA-approved to treat type 1 and type 2 debates. Humalog is typically used with intermediate-acting insulins or long-acting insulins. Fast-acting insulins can help cover insulin needs for meals eaten within 30 minutes of injection.

Humalog side effects

The side effects associated with taking Humalog are typically mild. Individuals taking insulin lispro (Humalog) report a variety of side effects, and side effects may vary from patient to patient.

  • The side effects of insulin lispro injection products may include:

    • Sudden weight gain

    • Low blood sugar levels

    • Low potassium

    Other side effects, which are less common but might be more severe, could include:

    • Hypokalemia (low blood potassium)

    • Hypoglycemia (severe low blood sugar)

    • Allergic reaction to insulin lispro products

    • Edema (swelling in the hands or legs)

    • Local amyloidosis at the injection site

    Call your doctor or pharmacist if you notice any adverse effects or if you develop any new or concerning symptoms. Talk with your doctor if you experience insulin weight gain while taking Humalog. Humalog is FDA-approved in children over the age of 3 with type 1 diabetes.

How to take Humalog

Your pharmacist will provide you with instructions on how to take your Humalog prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Humalog is a rapid-acting insulin dose that works faster than human insulin. You can inject Humalog under the skin using a syringe and needle, injection pen, or insulin pump.

Your doctor may prescribe Humalog or Humalog Mix (protamine and insulin lispro) to manage blood sugar. Your doctor will show you how to properly use insulin lispro by yourself. Humalog is taken within a dose window of 15 minutes before or after a meal.

What to avoid while taking Humalog

Humalog has several drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other prescription medicines, herbal supplements, and over-the-counter medicines.

Humalog (insulin lispro) injection drug interactions may include:

Tell your doctor if you're taking oral diabetes medicines, such as rosiglitazone or pioglitazone. Taking certain diabetes medications while using insulin injections can increase your risk of severe heart problems.

It's safe to drink alcohol while taking insulin lispro injectable suspension. However, you should avoid alcohol if your diabetes is not well controlled.

Never share your insulin pump or injection supplies with another person, even if the needle has been changed.

Medication alternatives to Humalog

If your healthcare provider prefers to put you on another treatment, they may suggest other insulins, such as other rapid-acting insulin analogs. Here are some common doctor-recommended alternatives based on your health issue:

Humalog prescription FAQs

  • How much does Humalog cost?

    Depending on your pharmacy, Humalog costs around $530 for a five-pack of 3 mL Humalog U-100 KwikPens without health insurance. Visit the Lilly diabetes solution center for more information about pricing options. Fortunately, generic brands, such as insulin lispro, may offer an affordable alternative.

  • How can I refill my Humalog prescription?

    To refill your insulin lispro (Humalog) prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Humalog?

    You should avoid taking Humalog if you have:

    • Low blood sugar levels (hypoglycemia)

    • A history of low blood sugar reactions

    • Allergic reactions to insulin products

  • How much Humalog can you take in a day?

    The starting dose for Humalog is about four units or about 10% of your long-acting insulin dose. You should take Humalog at your largest meal of the day.

  • How long can Humalog be unrefrigerated?

    Unopened Humalog vials should be refrigerated until you're ready to use them. Any unopened Humalog vials, cartridges, and prefilled pens should be discarded after 28 days when kept at room temperature.

  • How long does it take for Humalog to take effect?

    A fast-acting insulin dose such as Humalog starts working about 15 minutes after injection to lower blood sugar levels.

  • What is the difference between insulin lispro protamine and insulin lispro?

    Insulin lispro protamine is an intermediate-acting insulin, while insulin lispro is a fast-acting insulin.

3 simple steps to request your Humalog prescription today 

Step 1

Book a Humalog prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Humalog prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up Humalog.

We can send prescriptions to any local pharmacy.

Humalog prescription pricing details

How pricing works

To get a new or refill on your Humalog prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.