Humulin R (Human Recombinant) prescription available online 

If you are suffering from diabetes, Humulin R can help. Get a new prescription or refill of Humulin R today from a board-certified doctor online.*

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Take control of your blood sugar level

Available as an insulin human injection

Multiple FDA-approved uses for Humulin R

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Humulin R 

Humulin R is a intermediate acting insulin that belongs to the class of drugs called insulin. It is used to treat conditions such as diabetes by regulating the level of sugar in the blood. Humulin R is available only by prescription, in generic liquid injection formulations, and under different brand names like Novolin R.

Humulin R is prescribed as an insulin human injection. It is always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed. The most common side effects include low blood sugar levels (hypoglycemia), weight gain, and injection site reactions.

If you are prescribed Humulin R, be sure to complete the full course of the insulin unless your doctor specifically tells you to stop. If you don’t complete your prescription, it may not fully treat your condition.

Humulin R uses

There are several FDA-approved uses for Humulin R, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Diabetes

    For people with diabetes, Humulin R is used to help control blood sugar levels. It works by replacing the insulin your body can no longer produce on its own. Also, it helps your body use sugar more effectively. For kids, it's not allowed to be used as the first diabetes treatment.

  • Gestational Diabetes

    Humulin R is sometimes prescribed off-label to help in blood sugar control in women with gestational diabetes. Insulin therapy is usually needed when diet and exercise aren't effective in lowering blood sugar to a safe level.

  • Diabetic Ketoacidosis

    In people with type 1 diabetes, diabetic ketoacidosis can happen when there's insufficient insulin in the body. This can lead to a build-up of acids in the blood, known as ketones. Diabetic ketoacidosis is a serious condition that requires immediate medical treatment. Humulin R can help treat diabetic ketoacidosis (off-label) by helping to reduce ketone production.

  • Hyperosmolar Hyperglycemic State

    Hyperosmolar hyperglycemic state (HHS) is a serious complication of diabetes that can occur with an elevation of blood glucose. With hyperosmolarity with little or no ketosis, the body's cells become dehydrated, leading to organ damage and coma. Off-label Humulin R can be used to help treat HHS by replenishing human insulin levels and helping to reduce blood sugar.

Humulin R side effects

The side effects associated with taking Humulin R are typically mild. Most Humulin R side effects are associated with injection site discomfort. Humulin R has some common side effects. They may include:

    • Injection site reactions (pain, redness, irritation)

    • Weight gain

    • Low blood sugar (hypoglycemia)

    • High blood sugar (hyperglycemia)

    • Muscle cramps

    • Weakness

    • Irregular heartbeat

    Other side effects, which are less common but might be more severe, could include:

    • Allergic reaction

    • Dizziness

    • Trouble breathing

    • Signs of low potassium levels in the blood

    If any of the above side effects last or get worse, contact your doctor or pharmacist.

How to take Humulin R

Your pharmacist will provide you with instructions on how to take your Humulin R prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Humulin R can come in different forms and doses, so follow the specific instructions on your prescription. Some specific instructions may include injecting the insulin into the stomach area, the thigh, the buttocks, or the back of the upper arm. It is typically prescribed to be taken before meals.

Be sure to disinfect the injection site with rubbing alcohol before each insulin dose. Changing where you inject each time is important to reduce the risk of damage under the skin. The insulin should be clear and colorless. Do not inject the Humulin R if it is discolored or contains particles.

Also, do not inject Humulin R into red, swollen, itchy, or damaged skin. Injecting into a vein or muscle can cause very low blood sugar (severe hypoglycemia). Avoid rubbing the area after the injection.

Remember not to share your pen device under any circumstances. Doing so can cause a serious infection.

What to avoid while taking Humulin R

Humulin R has several drug interactions and it is important to check with your doctor or pharmacist before changing your medications. Tell your doctor if you're taking oral medications containing pioglitazone or rosiglitazone for diabetes as it may increase your risk of heart problems.

You should not use insulin if you're having a episode of hypoglycemia and always check the medicine label to avoid medication errors. Avoid drinking alcohol as it can interfere with your diabetes treatment. Frequent blood glucose monitoring along with insulin dosage and glycemic control will help.

Medication alternatives to Humulin R

If your healthcare provider prefers to put you on another treatment, they may suggest Farxiga or insulin in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Farxiga

    Farxiga is an oral medication used alongside diet and exercise to lower blood glucose levels in people with type 2 diabetes, often in addition to other medications. It may also be given to reduce the risk of worsening renal function, end-stage kidney disease, and cardiovascular or renal death in people with chronic kidney disease (CVD). Increased risk of genital and urinary tract infections is a possible side effect of short-acting insulin with a blood glucose-lowering effect.

  • Metformin

    Helping the body to better respond to insulin, metformin is commonly prescribed for type 2 diabetes. Side effects may include taste disturbances, diarrhea, and other stomach-related issues. Weight gain is unlikely. It's mainly used to treat type 2 diabetes but may also be prescribed to treat conditions such as insulin resistance syndrome, polycystic ovary syndrome, and diabetes type 3c off-label.

Humulin R prescription FAQs

  • How Much Does Humulin R Cost?

    Humulin R insulin (human recombinant 100 units/mL) injectable solution costs approximately $56 for a supply of 3 milliliters. The cost may vary depending on the pharmacy. Also, be sure to check if your insurance covers the cost of Humulin R.

  • How Can I Refill My Humulin R Prescription?

    You can follow the instructions for refilling your Humulin R prescription from your healthcare provider. You can refill your Humulin R prescription online with PlushCare.

    Our doctors can refill your prescription online if you qualify. Simply book an appointment with one of our doctors, attend the visit with one of our clinicians on your phone or computer, and then they can electronically send a refill to your nearest pharmacy.

  • Who Should Not Take Humulin R?

    For children under the age of 2 with diabetes mellitus, Humulin R is not approved for use. Additionally, Humulin R should not be used to treat type 2 diabetes in children of any age. Also, for individuals who are allergic to insulin or having an episode of hypoglycemia (low blood sugar), Humulin R should not be used.

  • How Long Can Humulin R Be Unrefrigerated?

    As long as it is kept as cool as possible (below 30°C or 86°F), Humulin R can be left unrefrigerated. However, in-use vials must be used within 31 days or discarded, even if they still contain Humulin R U-100. Keeping your insulin cool will help ensure that it works properly.

  • What Happens If Insulin Gets Too Cold?

    If insulin gets too cold, it can lose its potency and will not work as well to lower blood sugar levels. It is important to keep your insulin at a cool temperature, but do not freeze it. Also, never use insulin that has been frozen.

  • How Long Is Humulin R Good For After Opening?

    Once a vial of Humulin R has been opened, it can be used for up to 31 days as long as it is kept at a cool temperature. Also, keep them away from heat and light. Discard the vial if it is not used within 31 days or if it has been frozen.

  • What Happens If I Miss a Dose of Humulin R?

    Following insulin regimen is essential but if you miss a dose of Humulin R, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses of Humulin R at the same time.

  • What Happens If I Take Too Much Humulin R?

    If you take too much Humulin R, your blood sugar level may drop too low (hypoglycemia). Symptoms of hypoglycemia include dizziness, sweating, shakiness, hunger, fast heartbeat, and feeling anxious or irritable. If you experience any of these symptoms, test your blood sugar level and seek medical help immediately.

3 simple steps to request your Humulin R prescription today 

Step 1

Book a Humulin R prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Humulin R prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Humulin R prescription.

We can send prescriptions to any local pharmacy.

Humulin R prescription pricing details

How pricing works

To get a new or refill on your Humulin R prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.