About Novolin N (NPH insulin)
Novolin N is considered a man-made intermediate-acting insulin drug, which functions by lowering levels of blood glucose (sugar). Like other human insulin medications, Novolin N is not effective for the treatment of diabetic ketoacidosis.
Novolin N is used to treat diabetes mellitus. Novolin N is available only by prescription. It is available in a generic formulation as well as under different brand names, including neutral protamine Hagedorn insulin (NPH insulin).
Novolin N may be prescribed as an injection or suspension. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.
If you're prescribed Novolin N, be sure to complete the full course of the human insulin unless your doctor specifically tells you to stop. If you don’t complete your prescription, NPH insulin may not fully treat your diabetes mellitus.
Novolin N uses
There are several FDA-approved uses for Novolin N, but it may also be used off-label to treat other conditions. Your online healthcare provider may prescribe it for any of the following common reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.
Diabetes mellitus
Novolin N is FDA-approved for the treatment of adult and pediatric patients with diabetes mellitus. As an intermediate-acting insulin, Novolin N promotes blood glucose control by lowering blood sugar.
Novolin N side effects
The side effects associated with taking Novolin N are typically mild. Most Novolin N side effects are associated with low blood sugar. Novolin N has some common side effects. They may include:
Low blood sugar
Weight gain, or swelling in the hands or feet
Itching or mild skin rash
Other side effects, which are less common but might be more severe, could include:Fluid retention (edema)
Serious allergic reaction
Low potassium levels
You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. The use of Novolin N is safe and effective for the pediatric population.
How to take Novolin N
Your pharmacist will provide you with instructions on how to take your Novolin N prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.
Novolin N can come in different forms and doses, so be sure to follow the specific instructions on your prescription. Your healthcare provider will work with you to choose a proper dose to treat high blood sugar. Insulin dose adjustment may be required.
Novolin N is injected under the skin. Your healthcare provider can show you how to properly inject your insulin dose by yourself. Avoid injecting Novolin N into damaged skin, and use a different injection site each time you give yourself an insulin dose.
What to avoid while taking Novolin N
Novolin N has 378 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.
Possible drug interactions with Novolin N include:
Novolin R (insulin regular)
Gabapentin
Furosemide
Ask your doctor for medical advice before drinking alcohol. Alcohol can lead to an increased risk of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar) depending on how much you drink.
Medication alternatives to Novolin N
If your healthcare provider prefers to put you on another treatment altogether, they may suggest another human insulin drug or diabetes medicine in another drug class. Here are some common doctor-recommended alternatives based on your health issue:
Novolin N prescription FAQs
How much does Novolin N cost?
Depending on your pharmacy, Novolin N costs around $155 for a supply of 10 mL without insurance. Fortunately, generic brands, such as NPH insulin, may offer an affordable alternative.
How can I refill my Novolin N prescription?
Novolin N is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.
Who should not take Novolin N?
To make sure Novolin N is safe for you, tell your doctor if you have:
Liver or kidney disease
Diabetic ketoacidosis
Low potassium levels
Low blood sugar
Allergic reactions to insulin
How long does Novolin N stay in your system?
Novolin N can stay in your system for up to 24 hours.
How long is Novolin N good out of the fridge?
Opened vials of Novolin N can be stored at room temperature for 42 days. Unopened vials of Novolin N can be stored at room temperature for 28 days.
What happens if Novolin N is taken after food?
Taking Novolin N after eating can increase your risk of low blood sugar (hypoglycemia). To treat low blood sugar quickly, drink fruit juice or non-diet soda.
What happens if you shake Novolin N?
Shaking a vial of Novolin N can cause insulin particles to stick to the vial, which can reduce the effectiveness of human insulin.
What happens if I miss a dose of Novolin N?
If you miss a dose of NPH insulin, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.
What happens if I take too much Novolin N?
If you've taken too much Novolin N, seek emergency medical attention or contact your local poison control center. An insulin overdose can cause life-threatening severe hypoglycemia (low blood sugar).
3 simple steps to request your Novolin N prescription today

Step 1
Book a Novolin N prescription request appointment.
Book a same day appointment from anywhere.

Step 2
Talk to your medical provider regarding your Novolin N prescription.
Visit with a doctor on your smartphone or computer.

Step 3
Pick up your Novolin N prescription.
We can send prescriptions to any local pharmacy.
Novolin N prescription pricing details
How pricing works
To get a new or refill on your Novolin N prescription, join our monthly membership and get discounted visits.
Paying with insurance
Membership
$14.99/month
First month free
First visit
Copay
For all visits
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price with insurance
Often the same as an office visit. Most patients with in-network insurance pay $30 or less!
We accept these insurance plans and many more:
Paying without insurance
Membership
$14.99/month
First month free
First visit
$129
Repeats only $99
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price without insurance
Initial visits are $129 and follow-ups are only $99 for active members.
If we're unable to treat you, we'll provide a full refund.
Novolin N prescription resources
Sources:
PlushCare is dedicated to providing you with accurate and trustworthy health information
American Diabetes Association. Insulin Basics. Accessed on November 18, 2022. https://diabetes.org/health-wellness/medication/insulin-basics
Food and Drug Administration. Novolin N prescription label. Accessed on November 18, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/019959s082lbl.pdf
Mayo Clinic. Insulin Human Isophane (Nph) (Subcutaneous Route). Accessed on November 18, 2o22. https://www.mayoclinic.org/drugs-supplements/insulin-human-isophane-nph-subcutaneous-route/description/drg-20484120
PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.