Diflucan (fluconazole) prescription available online

If you are suffering from fungal infections, including vaginal yeast infections in women or thrush, Diflucan (fluconazole) can help. Get a new prescription or refill of Diflucan from a board-certified doctor online.*

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FDA-approved yeast infection pills

Safely prescribed for various fungal infections*

Request Diflucan in as little as 15 minutes, with or without insurance*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card. Physician review is for medical accuracy and not for the endorsement of any particular drug.

About Diflucan (fluconazole)

Diflucan is considered an azole antifungal medication, which functions by inhibiting the growth of particular kinds of fungus. Like other antifungal medications, this drug can only be used to treat a fungal infection. It is ineffective against bacterial infections, such as urinary tract infections, because it will not work on bacteria. It will not work on viral infections either.

Some conditions that Diflucan is known to treat include yeast infections, including oropharyngeal, esophageal, and vaginal candidiasis. Diflucan is available only by prescription. Pfizer is the company that manufactures Diflucan. Other names for fluconazole include Azoflune, Afungil, Difluzol, and Candizol. The generic for Diflucan is called fluconazole.

Diflucan may be prescribed as a tablet, injectable, or oral suspension. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage that you are prescribed. Over-the-counter Diflucan is not available, as it is only available by prescription.

If you are prescribed Diflucan, be sure to complete the full course of the antifungal unless your doctor specifically tells you to stop. If you don’t complete your prescription, the medication may not fully treat your fungal infection. 

Diflucan (fluconazole) uses

There are several FDA-approved uses for Diflucan, but it may also be used off-label to treat other conditions. Your doctor may prescribe it for any of the following common reasons. It’s also possible that your health care provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Fungal infections

    Diflucan treats various fungal infections of the mouth, throat, esophagus, and vagina. It is usually used to cure candida infections that grow in the vaginal and oral areas. These infections can include:

  • Cryptococcal meningitis

    Diflucan can be prescribed to treat cryptococcal meningitis, a brain infection caused by a fungus called Cryptococcus.

  • Post-operation

    If there is a risk of developing a fungal infection after an operation, your doctor may prescribe fluconazole.

What are the pros and cons?



  • Treats many fungal infections

  • Can prevent fungal infections in people with weakened immune systems

  • A single dose is enough for some infections


  • Rarely can cause liver damage

  • Not safe for pregnancy

  • May cause headaches, dizziness, and upset stomach

Diflucan side effects

  • The side effects associated with taking Diflucan are typically mild to moderate. Most Diflucan side effects are associated with reaction to the antifungal. Diflucan has some common side effects. They may include:

    • Headache

    • Abdominal pain

    • Nausea

    • Dizziness

    • Skin rash

    • Diarrhea

    Other side effects, which are less common but might be more severe, could include:

    • Dark urine

    • Seizures

    • Swelling 

    • Exfoliative skin disorders

    • Bloating of face

    • Difficulty breathing

    • Loss of appetite

    You should tell your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms.

How to take Diflucan

Your pharmacist will provide you with instructions on how to take your Diflucan prescription.

Be sure to read your prescription label and follow the instructions for the fluconazole dosage. Call your doctor or pharmacy if you have any questions.

Diflucan can come in different forms and doses, so be sure to follow the specific instructions on your prescription. It is typically prescribed 1 time a day.

According to Pfizer manufacturers for Diflucan tablets (fluconazole oral):

  • Dose for vaginal candidiasis infection: Diflucan is a one-time oral dose of a 150 mg tablet for vaginal candidiasis.

  • Dose for oropharyngeal candidiasis: Diflucan prescribed for oropharyngeal candidiasis is a 200 mg tablet for the first day and, afterward, a 100 mg tablet per day.

  • Dose for candidiasis of the esophagus: Diflucan is prescribed for esophageal candidiasis at a dose of 400 mg for the first day, afterward 200-400 mg per day.

What to avoid while taking Diflucan

Diflucan has interactions with many drugs. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Diflucan can cause interactions with other drugs, including:

  • Antibiotics

  • Birth control

  • Statins for cholesterol

  • Erythromycin-containing drugs

  • Hismanal (astemizole)

  • Juxtapid (lomitapide)

  • Lozol (indapamide)

This is not a complete list of drug interactions with Diflucan. Be sure to talk to your doctor about all current and past medications.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Diflucan.

While Diflucan (fluconazole) have not been shown to interact with alcohol, drinking alcohol may cause an increased risk of some side effects, including stomach pain and nausea.

Medication alternatives to Diflucan

If your healthcare provider prefers to put you on another treatment altogether, they may suggest generic fluconazole or an antifungal in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Diflucan prescription FAQs

  • How can I get Diflucan over the counter?

    It is not possible to get Diflucan OTC in the United States, as it is only available by prescription. However, it is easy to get a prescription for Diflucan from one of our board-certified doctors online, after a qualifying evaluation. After reviewing your symptoms and medical history, if you are eligible, your doctor will send a prescription to your local pharmacy.

  • How long is Diflucan prescribed for?

    Depending on your history and the severity of your infection, Diflucan is often only prescribed as a one time dose, for just one day. However, you may need to take an additional dose or two, in the following days depending on your specific case and symptoms.

  • What is Diflucan used for?

    Diflucan is used to treat many forms of fungal infections, including oral thrush, skin, and vaginal fungal infections.

  • Can you buy Diflucan online?

    Yes, it is possible to get a prescription for Diflucan online from one of our board-certified doctors and pick it up at your local pharmacy, following a qualifying appointment. Simply book an appointment with one of our trusted doctors online. After reviewing your symptoms and medical history, if you qualify, your doctor will send a prescription for Diflucan to your local pharmacy for pickup.

  • How much does Diflucan cost?

    The price often ranges from $8-15 for a dose of fluconazole, Diflucan in generic form. Cost may vary by pharmacy and insurance coverage.

  • How can I refill my Diflucan prescription?

    Follow the instructions for refilling your Diflucan prescription from your healthcare provider. You can refill your prescription online by booking an appointment with one of our board-certified doctors.

    Simply book an appointment with one of our doctors, attend the visit with one of our clinicians on your phone or computer, and if you qualify, they can electronically send a refill to your local pharmacy.

  • What should I avoid when taking Diflucan?

    Diflucan can cause drug interactions with medications, including:

    • Antibiotics

    • Statins for cholesterol

    • Birth control

    • Erythromycin-containing drugs

    • Hismanal (astemizole)

    • Juxtapid (lomitapide)

    • Lozol (indapamide)

    This is not a complete list of drugs that may have interactions with Diflucan.

  • When should you not take Diflucan?

    You should not take Diflucan if you have the following conditions:

    • Chronic liver disease

    • Low magnesium and potassium level in the blood,

    • Pregnant or may become pregnant

    • Kidney disease

    • Allergic to azoles, the drug class of fluconazole

  • How many days of Diflucan can you take?

    This depends on the type of infection that it was prescribed for. For some cases, it might only be one day, whereas for others, it might be a few weeks. Please take Diflucan according to your prescription or doctor's advice.

  • How soon after taking Diflucan can you take another?

    Diflucan has a relatively long half-life, so it can last, on average, six to nine days in your system. It is important to note that everyone will metabolize the drug differently. Because it stays in the body so long, it is common for yeast infections to be cleared after a single dose.

  • What happens if I miss a dose of Diflucan?

    If you forget to take a dosage of this medication, take it immediately. However, if your next dose is approaching, omit the missed dose. Avoid taking a double dose unless directed by your doctor.

  • What happens if I take too much Diflucan?

    This drug can concentrate in your body, causing adrenal gland and heart problems. If you take too much fluconazole, call your local poison control center immediately.

3 simple steps to request your Diflucan prescription today 

Step 1: Book an appointment

Step 1

Book a Diflucan prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Diflucan prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up Diflucan.

We can send prescriptions to any local pharmacy. Prescriptions are provided at the doctor's discretion.

Diflucan prescription pricing details

How pricing works

To get a new or refill on your Diflucan prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.