Caplyta (lumateperone) prescription available online

If you are suffering from schizophrenia or bipolar depression, Caplyta can help. Get a new prescription or refill of Caplyta from a board-certified doctor online.*

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Multiple FDA-approved uses

Improve your mood and thinking

Treat schizophrenia and bipolar disorder

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Caplyta (lumateperone)

Caplyta is considered an antipsychotic medicine, which rebalances dopamine, serotonin, and glutamate to improve thinking, mood, and behavior.

Caplyta is used to treat schizophrenia and depressive episodes associated with bipolar disorder. Caplyta is available only by prescription. It is available in a generic formulation under different brand names, including lumateperone.

Caplyta may be prescribed as an oral capsule. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Caplyta, complete the entire course of the antipsychotic medicine unless your doctor specifically tells you to stop. If you don’t complete your prescription, the antipsychotic may not fully treat your schizophrenia or bipolar depression.

Caplyta (lumateperone) uses

There are several FDA-approved uses for Caplyta, but healthcare professionals may also prescribe it off-label to treat other medical conditions.

Your PlushCare doctor may prescribe Caplyta for the following reasons or other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Schizophrenia

    Caplyta is FDA-approved for the treatment of schizophrenia in adults. It can help improve both positive and negative symptoms of schizophrenia, including hallucinations, delusions, and disorganized thinking.

  • Bipolar disorder

    Caplyta is FDA-approved to treat bipolar I and bipolar II depression. It may also be prescribed as an adjunctive therapy with lithium or valproate.

Caplyta side effects

  • The side effects associated with taking Caplyta are typically mild. Most Caplyta side effects are associated with gastrointestinal discomfort. Caplyta has some common side effects. The most common adverse reactions include:

    • Nausea

    • Weight gain

    • Dizziness or drowsiness

    Other side effects, which are less common but might be more severe, could include:

    • Feeling unsteady, like you're about to pass out

    • Uncontrolled body movements

    • Trouble breathing or speaking

    • Neuroleptic malignant syndrome

    You should call your doctor if you notice any adverse effects or develop any other new or concerning symptoms. Caplyta is not approved for older adults with dementia-related psychosis or children under 18. Caplyta may increase the risk of suicidal thoughts in young adults under 24.

How to take Caplyta

Your pharmacist will provide you with instructions on how to take your Caplyta prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Caplyta can come in different forms and doses, so follow the specific instructions on your prescription. The recommended dosage of Caplyta is 42 mg once daily, with or without food.

Caplyta can lead to an increased risk of decreased blood pressure. Be careful getting up from a sitting or lying position and performing hazardous activities until you know how Caplyta affects you.

What to avoid while taking Caplyta

Caplyta has 566 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Caplyta include:

  • Antibiotics, antifungals, and antivirals

  • Blood pressure medication

  • Bronchodilator asthma medication

  • Cold or allergy medicine, including Benadryl

  • Medications used to treat depression, anxiety, or other mental illness

  • St. John's wort

Talk to your doctor before drinking alcohol. Drinking alcohol while taking Caplyta can increase your risk of adverse effects, such as dizziness, confusion, and difficulty concentrating. In addition, avoid consuming grapefruit or grapefruit juice while taking Caplyta.

Medication alternatives to Caplyta

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other antipsychotic drugs or mood stabilizers in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Schizophrenia

    Abilify (Aripiprazole)


    Quetiapine (Seroquel)

    Vraylar medication

    Clozaril (clozapine)

  • Bipolar depression

    Lithobid (lithium)

    Depakene (valproic acid)

    Depakote (divalproex sodium)

Caplyta prescription FAQs

  • How much does Caplyta cost?

    Depending on your pharmacy, Caplyta costs around $1,570 for thirty 42 mg capsules without insurance. Fortunately, generic brands, such as lumateperone, offer an affordable alternative.

  • How can I refill my Caplyta prescription?

    To refill your Caplyta prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy.

  • What is Caplyta used for?

    Caplyta is used for the treatment of schizophrenia and bipolar depression associated with bipolar I and bipolar II disorder.

  • Is Caplyta a mood stabilizer?

    No, Caplyta is not a mood stabilizer. Caplyta is an atypical antipsychotic medicine used to treat schizophrenia and bipolar depression. However, many patients treated with Caplyta notice statistically significant improvement in their mood.

  • What type of drug is Caplyta?

    Caplyta is an atypical antipsychotic.

  • Does Caplyta help depression?

    Caplyta can help treat depressive episodes in adults with bipolar I and bipolar II disorder. Caplyta is not approved to treat major depressive disorder (MDD).

  • Who should not take Caplyta?

    Avoid taking Caplyta if you have certain medical conditions, such as:

    Patients with dementia-related psychosis should avoid taking Caplyta. Elderly patients with dementia-related psychosis treated with Caplyta may face an increased risk of death.

  • What happens if I miss a dose of Caplyta?

    If you miss a dose of Caplyta, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Caplyta?

    If you've taken too much Caplyta, seek immediate medical attention or contact your local poison control center.

3 simple steps to request your Caplyta prescription today 

Step 1: Book an appointment

Step 1

Book a Caplyta prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Caplyta prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Caplyta prescription.

We can send prescriptions to any local pharmacy.

Caplyta prescription pricing details

How pricing works

To get a new or refill on your Caplyta prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.