Z-Pack (azithromycin) prescription available online

If you are suffering from a bacterial infection, Z-Pack (azithromycin) can help. Get a new prescription or refill of azithromycin today from a board-certified doctor online.*

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Relief with Azithromycin

Prescription Z-pack for infections*

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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Z-Pack (azithromycin)

Azithromycin is considered one of the macrolide antibiotics which stops bacteria's growth. Like any antibiotic, you can only use this medication for bacterial infections. It is ineffective against viral infections, and it will not treat COVID, the cold, or the flu.

Some conditions that azithromycin is known to treat include infections such as bronchitis, pneumonia, ears, lungs, and other organs, respiratory infections, skin infections, sexually transmitted diseases, bacterial inflammation, and middle-ear infections in children. Azithromycin is available only by prescription. It is available in a generic formulation under different brand names, including Zithromax, Zithromax Z-Pak, Zmax, AzaSite, and Zithromax TRI-PAK.

Azithromycin may be prescribed as oral tablets, liquids, injections, and intravenous drips. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed azithromycin, be sure to complete the course of the antibiotic unless your doctor specifically tells you to stop. 

The antibiotic may only fully treat your infection if you complete your prescription. 

Z-Pack (azithromycin) uses

There are many different uses for azithromycin, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • COPD exacerbations

    Acute bacterial exacerbations of chronic obstructive pulmonary disease in adults can be treated with azithromycin.

  • Bacterial sinus infections

    While it used to be one of the first-line medications for sinus infections, azithromycin has now become an alternative medication for acute bacterial sinusitis in adults due to increasing rates of bacterial resistance to azithromycin. While it does still have some efficacy, there are other medications that have better rates of cure in the treatment of bacterial sinusitis.

  • Inflammation of the Urethra

    Urethritis can be caused by an STI in adults. Azithromycin can be prescribed to treat chlamydia in certain populations.

  • Genital chancroids

    This medication can be used for genital ulcer disease in men due to Haemophilus ducreyi (chancroid).

  • Middle Ear Infection (children)

    Azithromycin can be used to treat acute otitis media in pediatric patients as an alternative medication for those that are unable to use first-line treatment.

  • Pneumonia

    Community-acquired pneumonia in adults and pediatric patients can be treated using azithromycin.

  • Strep Throat

    Azithromycin can be used to treat pharyngitis or tonsillitis in adults and pediatric patients in patients as an alternative to first-line therapy in patients who cannot use first-line therapy.

What are the pros and cons?



  • Effective against many types of bacteria

  • Usually only taken for 5 days

  • Only one dose needed per day


  • Overuse can lead to bacterial resistance

  • May cause diarrhea and nausea

  • Ineffective against viral infections

Z-Pack (azithromycin) side effects

  • The side effects associated with taking azithromycin are typically mild. Most azithromycin side effects are associated with gastrointestinal discomfort or allergic reactions. Azithromycin has some common side effects. They may include:

    Other side effects, which are less common but might be more severe, could include:

    • Severe allergic reaction

    • Liver injury

    • Diarrhea associated with antibiotic-resistant bacteria

    • Fast or pounding heartbeats

    • Sudden cardiac death

    • Severe dizziness

    • Severe intestinal conditions

    You should call your doctor if you notice any of these side effects or develop other new or concerning symptoms. The side effects are rarely fatal, but it is always best to tell your doctor if any conditions arise. The use of azithromycin in young children six months and older is approved.

How to take Z-Pack (azithromycin) safely

Your pharmacist will provide you with instructions on how to take your azithromycin prescription.

Be sure to read your prescription label and follow the instructions. Then, call your doctor or pharmacy if you have any questions.

Azithromycin can come in different forms and doses, so follow the specific instructions on your prescription. It is typically prescribed as a five-day pill regimen with a dose of 500 mg (2 tablets of 250 mg) on the first day and 250 mg for the remaining four days.

What to avoid while taking Z-Pack (azithromycin) tablets

Azithromycin has 333 possible drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

Avoiding excessive sunlight exposure when taking azithromycin is essential as it can make you sunburn more easily.

Ask your doctor or pharmacist if consuming alcohol while taking azithromycin is acceptable.

There are no documented interactions between azithromycin and alcohol. However, drinking more alcohol is not recommended when fighting an infection because it may hinder the body’s ability to fight the disease, lead to dehydration, interrupt sleep, and worsen common side effects such as nausea, diarrhea, vomiting, and abdominal pain. It can also decrease effectiveness.

Avoid taking azithromycin if you have a specific muscle disease.

Do not take azithromycin if you take Nelfinavir. This drug can increase the amount of azithromycin in the blood. If you’re concerned about this interaction, tell your doctor to check for liver abnormalities and hearing impairment.

Do not take azithromycin if you take warfarin. Taking warfarin with azithromycin increases the blood thinning effect.

Tell your doctor or pharmacist about your medical history and other drugs you are taking before taking azithromycin.

Medication alternatives to Z-Pack (azithromycin)

If your healthcare provider prefers to put you on another treatment, they may suggest another macrolide antibiotic or a bacterial antibiotic in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Z-Pack (azithromycin) prescription FAQs

  • How much does Z-Pack (azithromycin) cost?

    The average price for azithromycin is 36 dollars which break down to $6 per pill. This cost will fluctuate based on the pharmacy and insurance.

  • How can I fill my Z-Pack (azithromycin) prescription?

    Your doctor or pharmacist can send azithromycin to any local pharmacy. Some common locations include CVS, Walmart, Rite Aid, and Walgreens.

  • What time of day should Z-Pack (azithromycin) be taken?

    Take azithromycin at the same time each day. Morning is recommended, as some users have trouble sleeping after taking azithromycin. When taking azithromycin capsules, take them at least 1 hour before food or 2 hours after eating.

  • When should you not take Z-Pack?

    You should not take azithromycin if you take any drug which interacts with azithromycin, including nelfinavir or warfarin, as the risk of adverse side effects is more significant. In addition, specific drug interactions may occur with other drugs, so always tell your doctor or pharmacist if you experience any unusual tiredness or severe dizziness.

  • What should I check before taking Z-Pack (azithromycin)?

    Observe for signs and symptoms of anaphylaxis as this can be a sign of an allergic reaction which can be severe in some patients.

  • What happens if I miss a dose of Z-Pack (azithromycin)?

    Take the missed dose as soon as possible, but skip the missed dose if it is near your current dosage time.

  • What happens if I take too much Z-Pack (azithromycin)?

    Taking too much azithromycin could cause irregular heart rhythm or liver damage. If you consume too much azithromycin, you should call your doctor, contact your local Poison Control Center, or seek emergency medical attention immediately.

  • Can I buy a Z-pack (azithromycin) over the counter?

    Antibiotics like Z-pack (azithromycin) are available by prescription only and can't be purchased over the counter. If you need treatment for an infection quickly, our online doctors are available 24/7 to help you diagnosed and have an online prescription sent immediately to your local pharmacy.

    While generally safe, antibiotics like azithromycin can interact with other medications you are taking and may carry the risk of rare but serious side effects. Antibiotics are also only effective against bacterial infections; a doctor's diagnosis is necessary to help determine if Z-pack is the right treatment. Using antibiotics for viral infections or other conditions is ineffective and can contribute to antibiotic resistance, a serious public health threat where bacteria become resistant to antibiotic treatment.

    Your doctor will also determine the right dose and duration of azithromycin treatment based on the severity of your infection and your individual health factors. Taking the wrong dosage or duration can be ineffective or even harmful.

    If you're experiencing symptoms that might indicate an infection, schedule a doctor's appointment online or locally to get a proper diagnosis and treatment plan.

3 simple steps to request your Azithromycin prescription today

Step 1: Book an appointment

Step 1

Book a Z-Pack prescription request appointment.

You can book a same-day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Z-Pack prescription.

Then, you can visit a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Z-Pack prescription.

We can send prescriptions to any local pharmacy.

How to talk to your doctor about Z-Pack (azithromycin) for bacterial infections:

At Plushcare, our priority is making sure you receive the information and advice you need when making decisions about your health and wellness. Our board-certified doctors are here to help you every step of the way, focusing on genuine patient connection to help you feel confident and secure in your treatment journey. Here are some questions that may be helpful to discuss with your doctor:

  • What type of infection do you think I have? 

  • How long does it typically take for infection to clear up with a course of Z-pack?

  • Is there a chance my infection won’t respond to this treatment?

  • Will Azithromycin interact with any of my other current medications?

  • What should I do if I experience negative side effects?

  • If the infection isn’t improving with this treatment, what are the next steps?

  • What food or drink should I avoid while taking Azithromycin?

  • Should I take this medication with food?

  • Are there additional ways to clear up symptoms alongside medication?

  • When should I schedule a follow up appointment?

Z-Pack (azithromycin) prescription pricing details

How pricing works

To get a new or refill on your azithromycin prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Z-Pack (Azithromycin) prescription resources


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.