Z-Pack (Azithromycin) Prescriptions Available Online Today

Our doctors are here to help. A Z-Pack (Azithromycin or Zithromax) can treat bacterial infections and more. Speak to one of our board-certified doctors to see if a Z-Pack is right for you.

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An doctor at PlushCare can help you request a prescription online from your phone.

Can You Get a Z-Pack (Azithromycin) Online?

Yes, licensed medical doctors can prescribe a Z-Pack (Azithromycin, also known as Zithromax) online after a medical evaluation.

You can speak with one of our online doctors to learn more about Z-Pack. Book an online appointment with one of our top doctors using your phone or computer.

During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for a Z-Pack, they can write a prescription and electronically send it to a nearby pharmacy for pickup.

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What Is a Z-Pack (Azithromycin)?

Z-Pack is the brand name for azithromycin, a macrolide-type antibiotic. It is mostly used to treat respiratory tract infections such as pneumonia. 

It comes in a simple, easy-to-understand blister pack, where you take two pills the first day, then one pill a day for 4 additional days. 

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We can send prescriptions to any local pharmacy or by mail.

Z-Pack Prescription FAQs

How Does a Z-Pack Work?

Z-Pack and other macrolide antibiotics work by preventing bacteria from making their own proteins. By preventing the production of these proteins, bacteria cannot multiply and die out.

Note that while Azithromycin is a great antibiotic for some bacterial infections, it is not a first-line treatment for other bacterial infections, and is therefore not always the best antibiotic to use in all circumstances. Your doctor will evaluate your situation and decide if Azithromycin makes sense for you based on your disease, past and present medical conditions, and allergy profile.

What is the Typical Dosage of a Z-Pack?

Z-Pack comes in a convenient blister pack for easy dosing. Always follow your doctor’s instructions, but typical dosing is an initial dose of 500 mg (2 pills), then 250 mg (1 pill) per day for 4 days.

Z-Pack can be taken with or without food. Compared to other macrolides, it is given once a day because it has a longer half-life and it is removed from your blood slowly. Many infections only require a once-a-day 5-day regimen.

What are the Benefits of Z-Pack?

Z-Pack is a convenient way to take antibiotics since it comes in an easy-to-understand blister pack. Z-Pack should not be used to treat viral infections. 

Some of the bacterial infections that Z-pack may treat include:

  • Cat-scratch disease
  • Skin infections
  • Ear infections
  • Throat or tonsil infections
  • Sinusitis
  • Bronchitis
  • Pneumonia
  • Whooping cough (pertussis)
  • Chronic obstructive pulmonary disease (COPD)
  • Genital ulcers
  • Gonorrhea
  • Infections of the cervix or urethra
  • Severe pelvic inflammatory disease

What are the Side Effects of a Z-Pack?

Zithromax is a powerful medication, and it thus comes hand in hand with a range of potential side effects. Discuss the pros and cons with your doctor to determine whether the benefits of Zithromax outweigh the potential risks that it might cause.

Some side effects associated with the use of Zithromax include:

  • Diarrhea or constipation
  • Nausea
  • Abdominal pain
  • Stomach upset
  • Vomiting
  • Dizziness
  • Headaches
  • Tiredness or weakness
  • Nervousness
  • Changes in sleep patterns
  • Impaired or decreased sense of taste and smell

In rare cases, Zithromax may cause adverse reactions, such as:

  • Rashes or hives
  • Difficulty breathing
  • Swelling
  • Bleeding or bruising
  • Bloody stool or urine
  • Loss of consciousness
  • Hallucinations
  • Tightness of chest
  • Fast heartbeat

If these reactions occur, cease the use of Zithromax and seek prompt medical attention.

What are Possible Z-Pack Interactions?

Z-Pack may have interactions with certain medications. Always tell your doctor about all medications (including over-the-counter), vitamins, supplements, and other drugs that you take to help prevent complications. Avoid Z-Pack if you take any of the following:

  • BCG live (Theracrys)
  • Dronedarone (Multaq)
  • Pimozide (Orap)
  • Amiodarone (Cordarone, Pacerone, or Nextarone)
  • Live typhoid vaccine (Vivotif)
  • Digoxin (Lanoxin)
  • Quinidine
  • Blood thinners like enoxaparin (Lovenox), fondaparinux (Arixta), heparin, warfarin (Coumadin or Jantoven)
  • Medications used to prevent blood clots: bivalirudin (Angiomax), antithrombin III (Thrombin), dalteparin (Fragmin)

What are Considerations and Precautions of Z-Pack?

Zithromax is known to interact with a range of medications. Let your doctor know whether you are taking any maintenance medication and ask whether you can take over-the-counter medications while using Zithromax. Interactions can be harmful to your health, and in some cases, even fatal.

Some drugs that are known to interact with Zithromax include, but are not limited to:

  • Nelfinavir
  • Warfarin
  • Macrolides
  • Antipsychotic medication
  • Albuterol
  • Amoxicillin
  • Augmentin
  • Coumadin
  • Lipitor
  • Tramadol

In the same way, Zithromax is also known to have certain disease interactions. Individuals suffering from the following conditions should avoid the use of Zithromax or use the drug with caution and the recommendation of their doctor:

  • QT prolongation
  • Liver disease
  • Biliary disease
  • Abnormal heart rhythm
  • Kidney disease
  • Myasthenia gravis

Breastfeeding or pregnant women should avoid using Zithromax to eliminate the risk of passing the chemicals to their children. Keep in mind that these are not all-inclusive lists.

Note that while Azithromycin is a great antibiotic for some bacterial infections, it is not first line for other bacterial infections, and is therefore not always the best antibiotic to use in all circumstances. Your doctor will evaluate your situation and decide if Azithromycin makes sense for you based on your disease, past and present medical conditions, and allergy profile.

How Quickly Does a Z-Pack Work?

A Z-Pack typically takes 5 full days to work. If you begin to feel relief from your symptoms, do not stop taking your Z-Pack so as to avoid antibiotic resistance.

Can You Request a Z-Pack Prescription Online?

If you suspect that you might be suffering from a bacterial infection, then it is possible that your doctor may be able to prescribe an antibiotic to help you overcome the infection. Today, there is a range of antibiotics available on the market, each one working to eliminate an infection through its unique mechanism. Zithromax (also known as a Z-Pack with the generic name Azithromycin) is one of many medications your doctor might prescribe.

Before purchasing a Z-Pack, your pharmacy will require a prescription from a licensed doctor since Z-Pack is a prescription medication.

You can book an appointment online with one of our licensed primary care doctors to learn more about a Z-Pack. Your doctor will determine whether or not to prescribe a Z-Pack based on your online medical evaluation. Book an appointment with a PlushCare physician today to determine if a Zithromax prescription would be recommended for you as part of a treatment plan.

A Note About Z-Pack Prescriptions Online

Medications are prescribed at the sole discretion of a PlushCare physician. Prescriptions for non-controlled substances can only be written after a medical evaluation. Scheduling an appointment does not guarantee that a medication can or will be prescribed.


Telehealth is not appropriate for serious conditions that require immediate attention or emergency care. If you experience any life-threatening issues, call 911 or go to an emergency room immediately.


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