Mavyret (glecaprevir/pibrentasvir) prescription available online 

If you suffer from chronic hepatitis C, Mavyret can help. Request a new prescription or refill of Mavyret from a board-certified doctor online.*

Book an appointment

FDA-approved to treat chronic HCV

Available as tablets or oral pellets

Request Mavyret in as little as 15 minutes, with or without insurance*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Mavyret 

Mavyret contains a combination of glecaprevir, an NS3/4A protease inhibitor, and pibrentasvir, an NS5A inhibitor. Glecaprevir and pibrentasvir are antiviral medications that prevent the hepatitis C virus (HCV) from multiplying in your body.

Mavyret is used to treat chronic hepatitis C in people infected with hepatitis C virus genotype 1, 2, 3, 4, 5, or 6. Mavyret is available only by prescription. It is available in a generic formulation under different brand names, including glecaprevir and pibrentasvir.

Mavyret may be prescribed as tablets or oral pellets. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Mavyret, be sure to complete the entire course of the antiviral medication unless your healthcare professional specifically tells you to stop. The antiviral may not fully treat your chronic HCV infection if you don't complete your prescription.

Mavyret uses

There are several FDA-approved uses for Mavyret, but it may also be used off-label to treat other conditions. Your online healthcare professional may prescribe it for the following reasons.

It’s also possible that your healthcare professional may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Chronic hepatitis C infection

    Mavyret is FDA-approved to treat adult and pediatric patients 3 years and older with chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection with cirrhosis or without compensated cirrhosis (Child-Pugh A).

    Mavyret may be prescribed to treat adult and pediatric patients with HCV genotype who were previously treated with an NS5A inhibitor or an NS3/4A protease inhibitor, but not both.

Mavyret side effects

The side effects associated with taking Mavyret are typically mild. Most Mavyret side effects are associated with tiredness.

  • Mavyret has some common side effects. They may include:

    • Tiredness

    • Headache

    • Nausea and diarrhea


    Other side effects, which are less common but might be more severe, could include:

    • Right-sided upper stomach pain

    • Confusion or feeling lightheaded

    • Yellowing of the skin or eyes (jaundice)


    You should call your doctor if you notice any adverse effects, or if you develop any other new or concerning symptoms. In rare cases, Mavyret can cause serious liver problems. Call your healthcare professional right away if you notice any signs of liver disease or liver failure.

    The use of Mavyret is approved for pediatric patients over 3 years old.

How to take Mavyret

Your pharmacist will provide you with instructions on how to take your Mavyret prescription. It is essential to follow certain precautions and take Mavyret precisely as directed by your healthcare provider to maximize the effectiveness of the medication and minimize the risk of side effects. Here are some general guidelines for taking Mavyret:

  • Dosage: The recommended dosage of Mavyret is usually one tablet (glecaprevir 100 mg/pibrentasvir 40 mg) taken orally once daily with food.

  • Timing: Mavyret can be taken at any time of the day, with or without food. It is crucial to take Mavyret at the same time each day to maintain a consistent level of the medication in the bloodstream.

  • Swallowing: Mavyret tablets should be swallowed whole with water. Do not crush, chew or break the tablets.

  • Missed dose: If you miss a dose of Mavyret, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Take only a partial dose to make up for a missed dose.

  • Other medications: Mavyret may interact with other medications, so it is vital to inform your healthcare provider about any other medications you are taking, including prescription medications, over-the-counter medications, and herbal supplements.

  • Monitoring: Your healthcare provider will monitor your liver function and HCV RNA levels regularly to determine if Mavyret is working effectively and to adjust the dosage if necessary.


Always follow the instructions provided by your healthcare provider and the medication label when taking Mavyret, and do not hesitate to ask questions or seek guidance if you have any concerns.

What to avoid while taking Mavyret

It is essential to follow certain precautions and avoid certain things to maximize the effectiveness of the medication and minimize the risk of side effects. Here are some things to keep in mind:

  • Other medications: Mavyret can interact with other medications, so it is vital to inform your healthcare provider about all your medications, including prescription medications, over-the-counter medications, and herbal supplements. Possible drug interactions with Mavyret include:

  • Pregnancy and breastfeeding: Mavyret may harm a developing fetus or pass into breast milk, so it is essential to use effective contraception while taking Mavyret and to inform your healthcare provider if you are pregnant or breastfeeding.

  • Alcohol: It is recommended to avoid drinking alcohol while taking Mavyret, as it can increase the risk of liver damage.

  • Grapefruit and grapefruit juice: Grapefruit and grapefruit juice can increase the levels of Mavyret in the bloodstream, increasing the risk of side effects. It is crucial to avoid consuming grapefruit or grapefruit juice while taking Mavyret.

  • St. John's wort: St. John's wort can decrease the effectiveness of Mavyret, so it is essential to avoid using St. John's wort while taking Mavyret.

Medication alternatives to Mavyret

If your healthcare provider prefers to put you on another treatment, they may suggest another NSA/4A protease inhibitor or antiviral medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Chronic hepatitis C infection

    Epclusa (sofosbuvir/velpatasvir)

    Harvoni (ledipasvir/sofosbuvir)

Mavyret prescription FAQs

  • How much does Mavyret cost?

    Depending on your pharmacy, Mavyret oral pellets costs around $13,200 for a four-week supply. Fortunately, generic brands, such as glecaprevir and pibrentasvir, offer an affordable alternative.

  • How can I refill my Mavyret prescription?

    To refill your Mavyret prescription, book a virtual appointment with one of our top-rated board-certified doctors. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Mavyret?

    To make sure Mavyret is safe for you, talk to your doctor if you have any of the following conditions:

    • Hepatitis B virus

    • Liver problems other than hepatitis C virus, such as liver cancer or compensated liver disease

    • A liver or kidney transplant

    • Renal impairment

    • Human immunodeficiency virus (HIV)

    • History of opioid addiction

  • Does Mavyret make your hair fall out?

    No, hair loss is not a side effect of Mavyret.

  • How long do you have to be clean to get hep C treatment?

    Most states require a six-month to one-year period of sobriety before you can start HCV treatment.

  • How long does it take for Mavyret to start working?

    Mavyret starts working soon after your first dose. Clinical trials show that Mavyret cures hepatitis C in most people within 8–16 weeks when taken as directed.

  • What happens if I miss a dose of Mavyret?

    If you miss a dose of prednisone, take the missed dose as soon as you remember. Skip the missed dose if you're over 18 hours late for the dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Mavyret?

    If you've taken too much Mavyret, seek emergency medical attention or contact your local poison control center.

3 simple steps to request your Mavyret prescription today 

Step 1

Book a Mavyret prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Mavyret prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up Mavyret.

We can send prescriptions to any local pharmacy.

Mavyret prescription pricing details

How pricing works

To get a new or refill on your Mavyret prescription, join our monthly membership and get discounted visits.

Paying with insurance

Membership

$16.99/month

First month free

Visits

Copay

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance

Membership

$16.99/month

First month free

Visits

$129

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Mavyret prescription resources

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