As the Centers for Disease Control and Prevention (CDC) pointed out, coronary artery disease is the most common cause of heart attacks in the United States. This happens when a cholesterol-containing substance called plaque gets deposited and builds up inside the arteries (also known as atherosclerosis), narrowing the arteries and reducing blood flow to parts of the heart muscle. Eventually, if a plaque breaks open inside the artery, it causes blood clot formation on the plaque's surface. A large blood clot is capable of blocking blood flow to the heart.