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About anticoagulants
Anticoagulants are medications designed to reduce your blood's ability to clot. They break down existing blood clots and prevent new clots from forming. They’re often prescribed to treat blood clots, but they’re also used for other conditions. There are three prescription anticoagulants: vitamin K antagonists, direct oral anticoagulants, and low molecular weight heparin anticoagulants.
What anticoagulants treat
The most common condition treated with anticoagulants is blood clots. When blood clots form in your bloodstream, they can become life-threatening. Large blood clots can get stuck in smaller blood vessels, which can block blood flow to your organs.
Blockages from blood clots can lead to life-threatening conditions, such as stroke, heart attack, pulmonary embolism, and venous thromboembolism. Anticoagulant therapy works by interrupting the formation of blood clots. They're sometimes called "blood thinners," although they don't actually make your blood thinner.
Types of anticoagulants available online
The three types of anticoagulant medications are called vitamin K antagonists, direct oral anticoagulants, and low molecular weight heparins. Depending on the type of anticoagulant, your medication will disrupt the clotting process in different ways to prevent clots.
Vitamin K antagonists
Vitamin K antagonists block vitamin K—a key ingredient in the clotting process. However, vitamin K antagonists often require careful dosing and regular laboratory monitoring to prevent complications or adverse reactions. Without the right dosage, vitamin K antagonists may lead to severe bleeding.
For some medical conditions, warfarin therapy is the best treatment option. If you have end-stage kidney disease, a mechanical valve, or diseases affecting your mitral valve, your healthcare provider will likely prescribe a vitamin K antagonist.
Examples of vitamin K antagonists include:
Direct oral anticoagulants (DOACs)
Direct oral anticoagulants typically work more quickly than vitamin K antagonists, and many DOACs do not require regular testing. However, direct oral anticoagulants work for shorter periods, so you may need to take medication more often than other oral anticoagulants.
Direct thrombin inhibitors, a type of DOAC, interfere with the body's use of thrombin, an enzyme that promotes clotting.
Examples of direct oral anticoagulants include:
Low molecular weight heparins (LMWH)
Low molecular weight heparin anticoagulants often bridge the long-term use of other oral anticoagulation therapy, such as warfarin. You may take both anticoagulants as your doctor monitors how you do on these medications. Doctors typically prescribe a fixed dose based on your body weight, which you inject under your skin.
Examples of low molecular-weight heparin anticoagulants include:
How anticoagulants work
If a blood clot blocks blood flow through a blood vessel, that part of your body can become deprived of oxygen and stop working correctly. Anticoagulants work by disrupting the formation of blood clots, which helps lower your risk of heart attack, stroke, deep vein thrombosis, and pulmonary embolism.
Anticoagulation therapy interferes with normal clotting factors to prevent or undo coagulation—the process where blood solidifies to form a blood clot. Different anticoagulants work differently to stop clotting.
Side effects of anticoagulants
When taken as prescribed, anticoagulants are generally well tolerated. However, they can still cause some side effects and increase your risk of bleeding. The more common side effects of anticoagulants include:
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Passing blood in your urine
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Stomach pain, nausea, and diarrhea
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Bleeding gums
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Prolonged bleeding from a cut
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Heavier menstrual periods
In rare cases, anticoagulants may cause serious side effects. These can include:
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Severe pain, such as stomachache or headache
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Dizziness or weakness
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Severe bleeding or bruising
Anticoagulant risks
Anticoagulant drug therapy is generally safe, but there are some risks if you have other medical conditions or take certain medications.
Before you take a prescribed anticoagulant, be sure to tell your doctor if you have any of the following conditions or issues:
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High blood pressure
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Ulcers or bleeding in your stomach, intestines, lungs, or urinary tract
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An infection in the lining of your heart (endocarditis)
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You recently had medical procedures on your eyes, brain, or spine
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Aneurysm or bleeding in the brain
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Congestive heart failure
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Liver or kidney disease
Tell your doctor if you have medical conditions that cause an increased risk of bleeding.
Anticoagulant drug interactions
When you begin a new medication, make sure to tell your doctor about any other prescription medications, over-the-counter medicines, or herbs you’re taking. Some medications that might interact with an anticoagulant include:
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Other antiplatelet agents or medicines to prevent clots
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Antibiotics or antifungal medicine
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Nutritional supplements that contain vitamin K
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Herbal products, such as St. John's wort
Anticoagulants you can get online
Anticoagulant FAQs
How should I take anticoagulants?
Take anticoagulants as prescribed by your healthcare provider. Most people take anticoagulation drugs once or twice daily, at the same times each day. It's important to follow your regular dosing schedule because some anticoagulation drugs can start to wear off within a day.
Certain anticoagulants, such as warfarin and Pradaxa (dabigatran), should be taken with water. Talk to your doctor if you have any questions about taking your prescription.
Who shouldn’t take anticoagulants?
To make sure anticoagulation therapy is safe for you, talk to your doctor if you have any of the following conditions:
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High blood pressure
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Ulcers or bleeding in your stomach, intestines, lungs, or urinary tract
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An infection in the lining of your heart (endocarditis)
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You recently had medical procedures on your eyes, brain, or spine
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Aneurysm or bleeding in the brain
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Congestive heart failure
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Atrial fibrillation
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Liver or kidney disease
In addition, tell your healthcare provider if you have any other medical conditions or take medications that may lead to an increased bleeding risk.
How long does it take for anticoagulants to work?
What should I avoid with anticoagulants?
Avoid any changes to your diet unless directed by your doctor. Foods that are high in vitamin K can make vitamin k antagonists less effective. Talk to your doctor about reducing your vitamin K intake if you're prescribed a vitamin K antagonist.
Grapefruit juice, cranberry juice, and pomegranate juice may interact with anticoagulation drug therapy and cause unwanted side effects. Avoid drinking these fruit juices and alcohol while taking an anticoagulant.
Ask your doctor for medical advice before taking medication for pain, arthritis, fever, or swelling. These medicines may affect blood clotting and increase your risk of bleeding.
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Anticoagulant resources
Sources:
PlushCare is dedicated to providing you with accurate and trustworthy health information.
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Cleveland Clinic. Anticoagulants (Blood Thinners). Accessed on October 19, 2022. https://my.clevelandclinic.org/health/treatments/22288-anticoagulants
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MedlinePlus. Blood Thinners. Accessed on October 19, 2022. https://medlineplus.gov/bloodthinners.html
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National Health Service. Anticoagulants. Accessed on October 19, 2022. https://www.nhs.uk/conditions/anticoagulants/
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