Hygroton (chlorthalidone) prescription available online 

If you are suffering from edema or high blood pressure, Hygroton (chlorthalidone) can help. Get a new prescription or refill of Hygroton from a board-certified doctor online.*

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FDA-approved to treat high blood pressure and edema

Helps improve blood flow

Request Hygroton in as little as 15 minutes, with or without insurance*

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Hygroton (chlorthalidone)

Hygroton is considered a thiazide diuretic, which prevents the body from absorbing too much salt. It also helps relax the blood vessels to improve blood flow.

Hygroton is used to treat high blood pressure and fluid retention (edema). Hygroton is available only by prescription. It is available in a generic formulation known as chlorthalidone, as well as under different brand names.

Hygroton may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Hygroton, be sure to complete the full course of the diuretic unless your health care professional specifically tells you to stop. If you don’t complete your prescription, the diuretic may not fully treat your fluid retention or high blood pressure.

Hygroton uses

There are several FDA-approved uses for Hygroton, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your health care professional may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • High blood pressure

    Hygroton is FDA-approved to treat high blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems.

  • Edema (fluid retention)

    Hygroton is FDA-approved to treat fluid retention in patients with congestive heart failure and kidney or liver trouble. It can also treat edema caused by taking steroids or estrogen.

Hygroton side effects

  • The side effects associated with taking Hygroton are typically mild. Most Hygroton side effects are associated with low blood pressure. Hygroton has some common side effects. They may include:

    • Low blood pressure (feeling dizzy or lightheaded)

    • Nausea or upset stomach

    • Dry mouth

    Other side effects, which are less common but might be more severe, could include:

    • Electrolyte imbalance

    • Kidney or liver trouble

    • Unusual bleeding

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Tell your doctor immediately if you notice any signs of liver or kidney problems.

    It is not known whether Hygroton is safe and effective in children under the age of 18.

How to take Hygroton

Your pharmacist will provide you with instructions on how to take your Hygroton prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Hygroton can come in different forms and doses, so be sure to follow the specific instructions on your prescription. For adults with high blood pressure, the initial dose typically starts at 25 mg orally once daily. For adults with fluid retention, the usual dose ranges from 50 mg to 100 mg once daily.

Hygroton should be taken in the morning with food. Your doctor may increase your dose gradually to meet your blood pressure goals. Your doctor will check your blood pressure regularly, and blood tests will be done occasionally.

What to avoid while taking Hygroton

Hygroton has 441 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Hygroton include:

  • Other heart and blood pressure medications

  • Lithium

  • Digoxin or digitalis

  • Insulin or oral diabetes medicine

  • Steroid medicine

Avoid drinking alcohol when taking Hygroton. Alcohol can cause low blood pressure, which can lead to an increased risk of dizziness, headache, fainting, and other side effects.

Avoid getting up too fast from a sitting or lying position to help your body adjust to the change in position and blood pressure, or you may feel dizzy. Make sure to drink water during exercise and in hot weather to prevent dehydration.

Medication alternatives to Hygroton

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other diuretics or antihypertensive agents in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Hygroton prescription FAQs

  • How much does Hygroton cost?

    Depending on your pharmacy, Hygroton (25 mg) costs around $19 for 30 tablets without insurance. Generic brands, such as chlorthalidone, can offer an affordable alternative. Price varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my Hygroton prescription?

    Hygroton is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • What medications should not be taken with Hygroton?

    Possible interactions with Hygroton include:

    • Other heart and blood pressure medications, including diuretics

    • Lithium

    • Digoxin or digitalis

    • Insulin or oral diabetes medicine

    • Steroid medicine

  • How much does Hygroton lower BP?

    On average, Hygroton reduces blood pressure by 18/15 Hg after four weeks of treatment.

  • Who should not take Hygroton?

    To make sure Hygroton is safe for you, tell your doctor if you have:

    • A serious allergic reaction to sulfa drugs

    • Kidney disease or severe renal disease

    • Heart failure

    • Gout

    • High cholesterol or triglycerides

    • Diabetes

  • What happens if I miss a dose of Hygroton?

    If you miss a dose of Hygroton, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Hygroton?

    If you've taken too much Hygroton, seek emergency medical attention or contact your local poison control center.

3 simple steps to request your Hygroton prescription today 

Step 1: Book an appointment

Step 1

Book a Hygroton prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Hygroton prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Hygroton prescription.

We can send prescriptions to any local pharmacy.

Hygroton prescription pricing details

How pricing works

To get a new or refill on your Hygroton prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.