Glucovance (glyburide and metformin) prescription available online 

If you are suffering from type 2 diabetes, Glucovance (glyburide and metformin) can help. Get a new prescription or refill of Glucovance from one of our board-certified doctors online.

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Medication services available for adults and kids (3+)

Top quality, board-certified doctors

Insurance accepted, but not required

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and our prescription discount card.

3 simple steps to request your Glucovance prescription today 

Step 1

Book a Glucovance prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Glucovance prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Glucovance prescription.

We can send prescriptions to any local pharmacy.

Glucovance prescription pricing details

How pricing works

To get a new or refill on your Glucovance prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Glucovance prescription FAQs

  • How much does Glucovance cost?

    Depending on your pharmacy, Glucovance typically costs around $144 for one-hundred 2.5 mg/500 mg tablet supply without insurance. Fortunately, generic brands, such as glyburide and metformin, offer an affordable alternative.

  • How can I refill my Glucovance prescription?

    To refill your Glucovance prescription, book a virtual appointment with one of our top rated board-certified doctors. After reviewing your symptoms, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Glucovance?

    To make sure Glucovance is safe for you, tell your doctor if you have:

    • Kidney disease

    • Liver disease

    • A history of heart disease, heart attack, or stroke

    • An allergic reaction to glyburide or metformin

    • Metabolic acidosis

  • What happens if I miss a dose of Glucovance?

    If you miss a dose of Glucovance, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Glucovance?

    If you've taken too much Glucovance, seek emergency medical attention or contact your local poison control center. An overdose may cause severe hypoglycemia (low blood sugar) or lactic acidosis.

  • What is the difference between metformin and Glucovance?

    Metformin is a biguanide that may be prescribed to treat type 2 diabetes. Glucovance is a combination therapy that consists of glyburide and metformin.

  • What is the generic name for Glucovance?

    The generic name for Glucovance is glyburide/metformin.

  • Does Glucovance increase weight?

    Weight gain is a possible side effect of Glucovance.

  • What is the difference between metformin and glyburide/metformin?

    While metformin may be prescribed alone to treat type 2 diabetes, glyburide/metformin is a combination therapy.

  • What is glyburide/metformin used for?

    Glyburide/metformin (Glucovance) is used to treat type 2 diabetes in combination with diet and exercise.

About Glucovance (glyburide/metformin) 

Glucovance contains a combination of glyburide and metformin, which are both oral diabetes medications that help control blood sugar. While glyburide lowers blood sugar by releasing natural insulin and decreasing the amount of sugar produced by the liver, metformin works to decrease the amount of sugar that the liver produces and that the stomach and intestines absorb.

Glucovance is used to treat type 2 diabetes. Glucovance is available only by prescription. It is available in a generic form as glyburide and metformin, as well as under different brand names.

Glucovance is typically prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Glucovance, be sure to complete the full course of the diabetes medication unless your doctor specifically tells you to stop. If you don’t complete your prescription, the anti-diabetic combination therapy may not fully treat your type 2 diabetes mellitus. 

Glucovance uses

There is one FDA-approved uses for Glucovance, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your clinician may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Type 2 diabetes mellitus

    Glucovance is FDA-approved to treat type 2 diabetes mellitus. It may be used in combination with diet and exercise to help with blood sugar control in adults with type 2 diabetes.

    Glucovance is not used to treat type 1 diabetes or diabetic ketoacidosis.

Glucovance side effects

  • The side effects associated with taking Glucovance are typically mild. Most Glucovance side effects are associated with low blood sugar. Glucovance's typical side effects include:

    • Hypoglycemia (low blood sugar)

    • Nausea, diarrhea, and upset stomach

    • Headache

    Other side effects, which are less common but might be more severe, could include:

    • Heart problems (swelling, rapid weight gain, shortness of breath)

    • Lactic acidosis (muscle pain, trouble breathing, stomach pain)

    • Severe low blood sugar (blurred vision, extreme weakness, rapid breathing).

    Tell your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Taking Glucovance can lead to an increased risk of lactic acidosis, which requires immediate medical attention. It is not known whether Glucovance is safe and effective in children.

How to take Glucovance

Your pharmacist will provide you with instructions on how to take your Glucovance prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Glucovance can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The starting dose of Glucovance typically ranges from 1.25 mg to 250 mg orally, taken once daily. Glyburide and metformin are often prescribed as an adjunct therapy in addition to diet and exercise.

What to avoid while taking Glucovance

Glucovance has 549 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other drugs or supplements, as well as over-the-counter drugs. 

Possible drug interactions with glyburide and metformin include:

  • Lipitor (atorvastatin)

  • Lasix (furosemide)

  • Monoamine oxidase inhibitors (MAOIs)

  • Blood thinners, such as warfarin

  • Other medications for diabetes

Drinking alcohol while taking Glucovance can increase your risk of developing lactic acidosis. Alcohol may also have additive effects in lowering your blood sugar, which can lead to dizziness, headache, and other adverse reactions. Avoid drinking alcohol while taking this medication.

Medication alternatives to Glucovance

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another combination therapy or a diabetes medication in another drug class. Here are some common doctor-recommended alternative to Glucovance: