Trazodone (Desyrel) online prescription available

If you are suffering from depression, trazodone (Desyrel) can help. Get a new prescription or refill of trazodone from a board-certified doctor online.*

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Effective treatment for depression

Improve sleep, ease anxiety

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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Desyrel (trazodone)

Desyrel is considered a serotonin antagonist and reuptake inhibitor (SARI), which helps restore the balance of serotonin in the brain. Desyrel can not only help improve mood, appetite, and energy levels, but also decrease insomnia and anxiety related to depression.

Desyrel is used to treat depression. Desyrel is available only by prescription. It is available in a generic formulation as trazodone hydrochloride, and under different brand names.

Desyrel may be prescribed as an oral tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Desyrel, be sure to complete the full course of the antidepressant unless your doctor specifically tells you to stop. If you don’t complete your prescription, the antidepressant may not fully treat your mental health concerns. 

Trazodone (Desyrel) uses

There is one FDA-approved use for trazodone, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for the following reason. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Depression

    Trazodone is FDA-approved to treat depression in patients with major depressive disorder (MDD). It can help improve mood, reduce anxiety, and treat insomnia related to depression.

    Desyrel may also be prescribed off-label to treat sleep issues related to other physical and mental illnesses.

Desyrel side effects

  • The side effects associated with taking Desyrel are typically mild. Most Desyrel side effects are associated with tiredness. Common side effects of trazodone may include: 

    • Dizziness or drowsiness 

    • Diarrhea or constipation 

    Other side effects, which are less common but might be more severe, could include: 

    •  Severe restlessness 

    • Serotonin syndrome 

    • Fast or pounding heartbeats 

    Tell your doctor if you notice any of these side effects, or if you develop any other new or worsening symptoms. The use of Desyrel in children under age 18 is not recommended.

How to take Desyrel (trazodone)

Your pharmacist will provide you with instructions on how to take your Desyrel prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Desyrel can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The starting dose of Desyrel is typically 50 mg/day, but your doctor may increase your dose as needed.

You should take Desyrel after a meal or snack. Don't stop taking trazodone hydrochloride suddenly or you may experience withdrawal symptoms, such as worsening depression or agitation. Call your doctor before stopping the medicine. 

What to avoid while taking Desyrel

Desyrel has many drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as other drugs.

Possible drug interactions with Desyrel include:

  • St. John's Wort

  • Other medications for mental illness, including MAO inhibitors

  • Diuretics (water pills)

  • Blood thinners, including warfarin

  • Medicine for migraine headaches

Talk to your doctor before you drink alcohol. Alcohol can increase the nervous system side effects of Desyrel, such as dizziness, drowsiness, and trouble concentrating.

Avoid hazardous activity until you know how Desyrel will affect you. Avoid getting up too quickly from a sitting or lying position or you may feel dizzy.

Medication alternatives to Desyrel (trazodone)

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other medication drug classes such as selective serotonin reuptake inhibitors (SSRIs). Here are some common doctor-recommended alternatives based on your health issue:

Desyrel prescription FAQs

  • How much does Desyrel cost?

    Depending on your pharmacy, Desyrel costs around $14 for fifteen 50 mg tablets without insurance. Generic brands, such as trazodone hydrochloride, may be even more affordable.

  • How can I refill my Desyrel prescription?

    Desyrel is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Who should not take Desyrel?

    To make sure Desyrel is safe for you, tell your doctor if you have certain medical conditions, such as:

    • Liver or kidney disease

    • Heart disease or history of heart attack

    • A blood clotting disorder

    • Bipolar disorder (manic depression)

    • Glaucoma

    • Seizures or epilepsy

    • Long QT syndrome

    • Suicidal thoughts

  • What time of day should Desyrel be taken?

    Take Desyrel as directed by your doctor. Your doctor may recommend taking it before bed if you are prescribed it to help treat insomnia.

  • What happens if you take Desyrel on an empty stomach?

    If you take Desyrel on an empty stomach, you may experience dizziness and/or lightheadedness.

  • What happens if I miss a dose of Desyrel?

    If you miss a dose of Desyrel, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Desyrel?

    If you've taken too much Desyrel, seek emergency medical attention or contact your local poison control center. Overdose symptoms can include extreme drowsiness, vomiting, or an irregular heartbeat.

3 simple steps to request your trazodone (Desyrel) prescription online today

Step 1: Book an appointment

Step 1

Book a Desyrel prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Desyrel prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Desyrel prescription.

We can send prescriptions to any local pharmacy.

Trazodone (Desyrel) prescription pricing details

How pricing works

To get a new or refill on your trazodone prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.