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Zyloprim (allopurinol) prescriptions available online

If you are suffering from joint pain or swelling, our doctors are here to help. If you are experiencing gout, Zyloprim (allopurinol) can help. Get a new prescription or refill of Zyloprim from a board-certified primary care doctor online.*
Prevent gout flares Available as a once-daily tablet Virtual care for joint pain
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About Zyloprim (allopurinol)

Zyloprim is a type of medication called a xanthine oxidase inhibitor, which functions by blocking the enzyme responsible for the metabolism of xanthine to the production of uric acid. The prevention of this reaction prevents the buildup of uric acid levels that causes gout. 

Like any xanthine oxidase inhibitor, this medication is only meant to be used for a limited period of time, and the patient must be re-evaluated before discontinuing the drug.

Zyloprim is primarily used to treat and prevent gout, but may also be used to reduce the chance of developing kidney stones caused by uric acid and calcium oxalate. It is also used to prevent what is known as tumor lysis syndrome, which can occur in patients receiving certain cytotoxic therapies as part of their cancer treatments.

Zyloprim is available only by prescription. It is available in a generic formulation as allopurinol, as well as under different brand names, including Altacoron, Xyloprim, Neuroplat, and Radodyl, among others.

Zyloprim may be prescribed as a once-daily tablet. Zyloprim should not be taken with other medications that interfere with the absorption of uric acid, such as methotrexate or sulfasalazine, because it may lead to low uric acid levels. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage that you are prescribed.

If you are prescribed Zyloprim, be sure to continue the course of the xanthine oxidase inhibitor unless your doctor specifically tells you to stop. If you don’t complete your prescription, the xanthine oxidase inhibitor may not adequately manage your condition.

Zyloprim uses

There are several FDA-approved uses for Zyloprim, but it may also be used off-label to treat other conditions. Your doctor may prescribe it for any of the following common reasons. It’s also possible that your doctor may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

Gout

A common FDA-approved use for Zyloprim is to treat gout and prevent it from causing flares.

Gout is a form of inflammatory arthritis. Gout attacks are known to be one of the most painful forms of arthritis, characterized by excruciating attacks that occur suddenly in a single joint – frequently in the middle of the night. The most commonly affected joint is the big toe, but gout is also seen in the ankles, knees, wrists, and hands.

Zyloprim functions by blocking the enzyme responsible for the metabolism of xanthine to the production of uric acid. This prevents the buildup of uric acid levels in people with increased uric acid levels, often caused gout, certain cancers and cancer treatments, as well as other drugs.

Zyloprim side effects

Most side effects associated with taking Zyloprimare are typically mild. They may include:

  • Upset stomach

  • Nausea

  • Diarrhea

  • Drowsiness


In the event that these symptoms persist or worsen, please consult your doctor right away.

This medication also has the potential to cause a non-serious rash. It is possible that you will not be able to tell the difference between a non-serious rash and a serious allergic reaction. Please call 911 right away if any allergic reaction develops.

It is critical to seek medical attention right away if a rash or other allergic symptoms develop because rarely, there is a chance of serious allergic reaction (possibly fatal) to allopurinol. These allergic hypersensitivity reactions are abbreviated SCAR, or severe cutaneous adverse reactions. Please seek immediate medical attention if you notice any of the following symptoms of an allergic reaction:

  • Rash

  • Itching/swelling (especially of the face/tongue/throat)

  • Severe dizziness

  • Trouble breathing


You should also call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. They may include:

  • Fever

  • Headache

  • Muscle aches and weakness

  • Insomnia

  • Muscle cramps

  • Dehydration

  • Hair loss

  • Irregular heartbeat


It should be understood that the prescription of this medicine is based on a benefit/risk assessment made by your doctor. The possibility of mild side effects should not usually be the reason to discontinue the use of this medication. Most people who use this medication do not experience serious side effects. Inform your doctor right away if you experience any serious side effects.

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How to take Zyloprim

Your pharmacist will provide you with instructions on how to take your Zyloprim prescription for your allopurinol treatment.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Zyloprim is administered in oral form. It is usually taken at least once daily at the same time every day, or based on the medical guidelines provided by your doctor. In order to reduce the incidence of upset stomach, Zyloprim should be taken after a meal. If your dose happens to be more than 300 milligrams a day, you may have to take several smaller doses during the day.

The typical starting dose is 100 to 200 milligrams a day. It is important to drink a full glass of water when using this medication. If there is a medical reason for you to drink less water, please consult your doctor for more instructions. After allopurinol is started, uric acid levels are rechecked around a month later to assess if the dose is working well enough, or if you may need more medicine to bring levels to a normal range.

Some specific instructions may include:

  • Do not exceed the recommended dose. Do not take more than specified amount or Zyloprim will lose its effectiveness and may cause side effects.

  • If you take Zyloprim with food, especially cold foods, drink a small amount of water 30 minutes before taking Zyloprim.

The dosage prescribed to you will be based on your particular medical condition and response to treatment. It is crucial that you use the medication according to your doctor's prescription guidelines.

If you are taking the medication for gout, it may take up to several weeks before this medicine has an effect. While the body seeks to remove excess uric acid, it is not uncommon for you to experience more gout attacks for several months while on this medication. Because of this, your doctor will likely also prescribe you a daily antiinflammatory such as colchicine or indomethacin for the first one to three months.

Dosages might be adjusted for certain patients. Always follow the directions given by your doctor and the instructions on the prescription label.

What to avoid while taking Zyloprim

Zyloprim has 59 possible drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

It is important to avoid alcohol, tea, coffee, and other hot beverages while taking Zyloprim.

Before taking Zyloprim (allopurinol), it is important to tell your doctor if you have ever had a severe reaction to it in the past, or have any other allergies. This product may contain certain inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor for more details.

Your doctor should be informed about your medical history before prescribing this medication. This is especially true if you have had any of the following:

  • Kidney or liver disease

  • Diabetes

  • High blood pressure (hypertension)

  • Unusual diets (e.g., fasting)

  • Family or personal history of HLA-B*5801-positive immune system 

Zyloprim (allopurinol) may make you drowsy. The use of alcohol or marijuana can worsen the condition. When taking Zyloprim (allopurinol), avoid operating any machinery, driving, or performing any task that requires alertness. The use of alcohol may also decrease the potential effectiveness of this drug; therefore, please limit alcohol consumption when taking this medication. Some research shows that regular alcohol consumption may increase the risk of kidney failure in people who have congestive heart failure. Regular alcohol consumption also negatively affects liver function.

Older adults may be at increased risk of side effects when using this drug. This is because as kidney function declines with age, it may be less effective at removing Zyloprim from the system.

Pregnant patients should discuss the risk and benefits of taking Zyloprim with your doctor. Zyloprim has the ability to pass into breast milk; nursing patients should consult their doctor before breastfeeding.

Medication alternatives to Zyloprim

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another xanthine oxidase inhibitor or a gout medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Gout

Colchicine (Colcrys, Mitigare)
Febuxostat (Uloric)
Indomethacin (Indocin, Tivorbex)

Zyloprim prescriptions FAQs

How much does Zyloprim cost?

Generic allopurinol is generally very affordable with prescription discount cards even if you do not have insurance. Brand name Zyloprim costs $1,155 for 100 tablets (i.e., 200 mg). Some insurance programs may cover up to 200 mg. Some prescriptions and plans require you to see a doctor to pick up a prescription each month, which can be done online by booking an appointment with one of our trusted doctors. Price varies with insurance coverage but is usually very low-cost. Our prescription discount card helps members save up to 80% on prescriptions.

How can I refill my Zyloprim prescription?

Zyloprim is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

Who should not take Zyloprim?

Zyloprim should not be taken by anyone with a history of kidney problems, heart conditions, uncontrolled high blood pressure, liver problems.

What happens if I miss a dose of Zyloprim?

If you miss a dose of Zyloprim, skip the missed dose and go back to your regular dosing schedule. Avoid double doses.

What happens if I take too much Zyloprim?

If you take more Zyloprim than the recommended dose, it affect your liver function. With high levels of Zyloprim in your body you may experience the following symptoms:

  • Nausea

  • Skin rash

  • Diarrhea

Is Zyloprim the same as allopurinol?

Zyloprim is the same as allupurinol. Allopurinol is the generic name, while Zyloprim is the brand name. There is no difference in the active ingredients.

When should Zyloprim be given?

Zyloprim is administered in oral form. It is usually taken at least once daily at the same time every day, or based on the medical guidelines provided by your doctor. In order to reduce the incidence of upset stomach, Zyloprim should be taken after a meal. If your dose happens to be more than 300 milligrams a day, you will have to take several smaller doses during the day.

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How pricing works

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Zyloprim prescription resources

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