Soliqua (insulin glargine and lixisenatide) prescription available online 

If you are suffering from type 2 diabetes mellitus, Soliqua can help. Get a new prescription or refill of Soliqua from a board-certified doctor online.*

Book an appointment

FDA-approved to treat type 2 diabetes mellitus

Available as an injection

Take control of your blood sugar

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Soliqua 

Soliqua is a combination of insulin glargine and lixisenatide. Insulin glargine is a long-acting insulin that lowers blood glucose (blood sugar), while lixisenatide helps the pancreas produce insulin more efficiently.

Some conditions that Soliqua is known to treat include type 2 diabetes mellitus. Soliqua is available only by prescription. It is available in a generic formulation under different brand names, including insulin glargine and lixisenatide.

Soliqua may be prescribed as an injection. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Soliqua, complete the entire course of the diabetes treatment unless your healthcare provider specifically tells you to stop. If you don’t complete your prescription, the diabetes treatment may not fully treat your type 2 diabetes mellitus.

Soliqua uses

There is one FDA-approved use for Soliqua, but it may also be used off-label to treat other conditions. Your online healthcare professional may prescribe it for any of the following common reasons.

It’s also possible that healthcare professionals may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Type 2 diabetes mellitus

    Soliqua 100/33 is FDA-approved to improve glycemic control in adults with type 2 diabetes mellitus that is inadequately controlled with basal insulin or lixisenatide. Like other diabetes medications, Soliqua should be part of a comprehensive treatment plan that includes diet and exercise.

    Soliqua is not effective for the treatment of type 1 diabetes or diabetic ketoacidosis.

Soliqua side effects

  • The side effects associated with taking Soliqua 100/33 are typically mild. Most Soliqua side effects are associated with low blood sugar. Soliqua has some common side effects. They may include:

    • Low blood sugar levels

    • Nausea or diarrhea

    • Headache

    • Cold symptoms, such as sore throat or runny nose

    • Skin reaction at the injection site

    Other side effects, which are less common but might be more severe, could include:

    • Low potassium or low blood pressure

    • Severe low blood sugar (hypoglycemia)

    • Sudden weight gain

    • Allergic reactions

    • Serious infection or severe rash at the injection site

    You should call your healthcare professional if you notice any of these side effects, or if you develop any other new or concerning symptoms. It is not known whether Soliqua 100/33 is safe and effective in children under 18 years of age.

How to take Soliqua

Your pharmacist will provide you with instructions on how to take your Soliqua prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Soliqua 100/33 can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The typical starting dose for adults who aren't currently on basal insulin is 15 units subcutaneously once daily. For patients receiving 30–60 units of basil insulin, the starting dose is typically 30 units subcutaneously once daily.

Soliqua 100/33 should be injected under the skin once daily within an hour of eating your first meal. The maximum dose of Soliqua 100/33 is 60 units daily.

What to avoid while taking Soliqua

Soliqua has 395 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other prescription drugs or supplements, as well as over-the-counter medicines. 

Possible drug interactions with Soliqua include:

Drinking alcohol while taking Soliqua 100/33 can cause severe low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia), depending on how much you drink. Talk to your healthcare provider before you drink alcohol.

Medication alternatives to Soliqua

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another basal insulin or other diabetes drugs in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Soliqua prescription FAQs

  • How much does Soliqua cost?

    Depending on your pharmacy, Soliqua costs around $860 for 100 units/33 mcg/mL of 15 mL subcutaneous solution without insurance. Fortunately, generic brands like insulin glargine and lixisenatide offer an affordable alternative.

  • How can I refill my Soliqua prescription?

    To refill your Soliqua prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your medical history, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Soliqua?

    Avoid taking Soliqua 100/33 if you have certain medical conditions, such as:

    • Severe allergic reaction to insulin products

    • Pancreatitis or gallbladder disease

    • Problems digesting food

    • Liver or kidney disease

    • Heart failure

  • How long is Soliqua good for out of the fridge?

    When a Soliqua pen is in use, you can leave it out of the refrigerator for 28 days. Make sure to replace pen needles when using Soliqua.

  • When is the best time to take Soliqua?

    Take Soliqua 100/33 in the morning within an hour of eating your first meal to effectively control blood sugar.

  • Where should I inject Soliqua?

    Inject Soliqua as directed by your doctor. Soliqua can be injected under the skin of your upper legs (thighs), upper arms, or stomach area (abdomen).

  • What happens if I miss a dose of Soliqua?

    If you've missed a dose of Soliqua, skip the missed dose and take the next dose at the regular time. Avoid taking two doses to make up for the missed dose.

  • What happens if I take too much Soliqua?

    If you've taken too much Soliqua 100/33, seek emergency medical attention or contact local poison control centers.

3 simple steps to request your Soliqua prescription today 

Step 1: Book an appointment

Step 1

Book a Soliqua prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Soliqua prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Soliqua prescription.

We can send prescriptions to any local pharmacy.

Soliqua prescription pricing details

How pricing works

To get a new or refill on your Soliqua prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.