Doxepin online prescription available for anxiety & depression

If you are suffering from depression and anxiety, Doxepin (Sinequan) can help. Get a same-day prescription or refill from a caring, board-certified doctor online.

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Medication services available for adults and kids (3+)

Top quality, board-certified doctors

Insurance accepted, but not required

*Prescriptions provided at doctor’s discretion.

About Doxepin

Doxepin (Sinequan) belongs to a class of drugs called tricyclic antidepressants, which affect the balance of certain chemicals (neurotransmitters) in the brain.

It is used to treat depression and anxiety and is available only by prescription. It is also available in a brand name formulation known as Sinequan.

Doexpin may be prescribed as an oral capsule or oral concentrate. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Doxepin, be sure to complete the full course of the tricyclic antidepressant unless your doctor specifically tells you to stop. If you don’t complete your prescription, the tricyclic antidepressant may not fully treat your depression or anxiety.

Doxepin (Sinequan) uses

There are several FDA-approved uses for Doxepin, but it may also be used off-label to treat other conditions. Your online physician may prescribe it for any of the following common reasons. It’s also possible that healthcare professionals may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Depression and anxiety

    Sinequan is FDA-approved to treat depression and/or anxiety.

    Sinequan may also be prescribed to treat psychotic depressive disorders with associated anxiety, including manic-depressive disorders. Sinequan may be prescribed off-label to treat insomnia or another mental illness.

Doxepin side effects to be aware of

  • The side effects associated with taking Sinequan are typically mild. Most Sinequan side effects are associated with tiredness. Sinequan has some common side effects. They may include:

    • Feeling dizzy, tired, or weak

    • Stomach pain, nausea, and diarrhea

    • Dry mouth

    Other side effects, which are less common but might be more severe, could include:

    • Unusual bruising or bleeding

    • Worsening depression or anxiety

    • Fever, chills, or sore throat

    You should call your doctor if you notice any of these side effects, or if you develop any other symptoms. Sinequan may be prescribed to treat insomnia in pediatric patients over 12 years of age.

How to take Doxepin

Your online doctor or pharmacist will provide you with instructions on how to take your Doxepin prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Doxepin can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The starting dose of doxepin hydrochloride is typically 75 mg taken once daily. Take doxepin at bedtime if you're taking the medication once a day.

What to avoid while taking Doxepin (interactions)

Doxepin has 661 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Doxepin include:

  • Other medications for depression or Parkinson's disease, such as isocarboxazid, phenelzine, and tranylcypromine

  • Selective serotonin reuptake inhibitors (SSRIs) or MAO inhibitors

  • Adderall (amphetamine/dextroamphetamine)

  • Neurontin (gabapentin)

  • Xanax (alprazolam)

Ask your doctor for medical advice about side effects before drinking alcohol. Drinking alcohol while taking doxepin can increase your risk of uneven heartbeats, extreme drowsiness, and other adverse side effects.

Avoid stopping doxepin without your doctor's advice. Stopping your medication can cause withdrawal symptoms.

Medication alternatives to Doxepin

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other tricyclic antidepressants or antidepressant drugs in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Doxepin medication FAQs

  • How much does doxepin cost?

    Depending on your pharmacy, doxepin (10 mg) costs around $17 for 30 capsules without insurance. Fortunately, generic brands, such as doxepin, offer an affordable alternative.

  • How can I refill my doxepin prescription online?

    Doxepin is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors online. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Who should not take Doxepin?

    To make sure doxepin is safe for you, tell your doctor if you have:

  • How long before bed should you take Sinequan?

    Take Sinequan 30 minutes before bed when you're ready to sleep.

  • How long does it take for doxepin to work?

    For most patients, it takes 2–3 weeks to experience the full effect of doxepin.

  • Does Sinequan work the first night?

    If you have insomnia, doxepin may start working within the first few days to treat your symptoms. Most people notice the effects of Sinequan within 2–3 weeks.

  • What happens if I miss a dose of doxepin?

    If you miss a dose of doxepin, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Sinequan?

    If you've taken too much Sinequan, seek emergency medical attention or contact your local poison control center. Serious symptoms can occur.

3 simple steps to request your doxepin prescription online 

Step 1: Book an appointment

Step 1

Book a Sinequan prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Sinequan prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Sinequan prescription.

We can send prescriptions to any local pharmacy.

How to talk to your doctor about Doxepin (sinequan):

At Plushcare, our priority is making sure you receive the information and advice you need when making decisions about your health and wellness. Our board-certified doctors are here to help you every step of the way, focusing on genuine patient connection to help you feel confident and secure in your treatment journey.

The following are some questions to ask your doctor about Doxepin and treatment for anxiety and depression:

  • When can I expect to start feeling the effects of the medication?

  • How will we track my progress and if this treatment is working for me?

  • What other treatments do you recommend alongside medication?

  • When is the best time to take my medication?

  • Are there any foods, drinks or supplements I should avoid while taking antidepressants?

  • Is there any specific type of therapy you recommend to help manage my symptoms?

  • Will I need to be on anxiety/depression medication for a long period of time?

  • What should I do if I don’t feel any improvement?

  • What are some alternative options if this particular treatment doesn’t work for me?

  • Will I experience any withdrawal symptoms if I stop taking this medication?

Sinequan prescription pricing details

How pricing works

To get a new or refill on your Sinequan prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.