Sinequan (doxepin) prescription available online 

If you are suffering from depression and anxiety, Sinequan (doxepin) can help. Get a new prescription or refill of Sinequan from a board-certified doctor online.

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Medication services available for adults and kids (3+)

Top quality, board-certified doctors

Insurance accepted, but not required

*Prescriptions provided at doctor’s discretion.

About Sinequan (doxepin)

Sinequan belongs to a class of drugs called tricyclic antidepressants, which affect the balance of certain chemicals (neurotransmitters) in the brain.

Sinequan is used to treat depression and anxiety. Sinequan is available only by prescription. It is also available in a generic formulation known as doxepin.

Sinequan may be prescribed as an oral capsule or oral concentrate. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Sinequan, be sure to complete the full course of the tricyclic antidepressant unless your doctor specifically tells you to stop. If you don’t complete your prescription, the tricyclic antidepressant may not fully treat your depression or anxiety.

Sinequan uses

There are several FDA-approved uses for Sinequan, but it may also be used off-label to treat other conditions. Your online physician may prescribe it for any of the following common reasons. It’s also possible that healthcare professionals may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Depression and anxiety

    Sinequan is FDA-approved to treat depression and/or anxiety.

    Sinequan may also be prescribed to treat psychotic depressive disorders with associated anxiety, including manic-depressive disorders. Sinequan may be prescribed off-label to treat insomnia or another mental illness.

Sinequan side effects

  • The side effects associated with taking Sinequan are typically mild. Most Sinequan side effects are associated with tiredness. Sinequan has some common side effects. They may include:

    • Feeling dizzy, tired, or weak

    • Stomach pain, nausea, and diarrhea

    • Dry mouth

    Other side effects, which are less common but might be more severe, could include:

    • Unusual bruising or bleeding

    • Worsening depression or anxiety

    • Fever, chills, or sore throat

    You should call your doctor if you notice any of these side effects, or if you develop any other symptoms. Sinequan may be prescribed to treat insomnia in pediatric patients over 12 years of age.

How to take Sinequan

Your pharmacist will provide you with instructions on how to take your Sinequan prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Sinequan can come in different forms and doses, so be sure to follow the specific instructions on your prescription. The starting dose of doxepin hydrochloride is typically 75 mg taken once daily. Take doxepin at bedtime if you're taking the medication once a day.

What to avoid while taking Sinequan

Sinequan has 661 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Sinequan include:

  • Other medications for depression or Parkinson's disease, such as isocarboxazid, phenelzine, and tranylcypromine

  • Selective serotonin reuptake inhibitors (SSRIs) or MAO inhibitors

  • Adderall (amphetamine/dextroamphetamine)

  • Neurontin (gabapentin)

  • Xanax (alprazolam)

Ask your doctor for medical advice about side effects before drinking alcohol. Drinking alcohol while taking doxepin can increase your risk of uneven heartbeats, extreme drowsiness, and other adverse side effects.

Avoid stopping doxepin without your doctor's advice. Stopping your medication can cause withdrawal symptoms.

Medication alternatives to Sinequan

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other tricyclic antidepressants or antidepressant drugs in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Sinequan prescription FAQs

  • How much does Sinequan cost?

    Depending on your pharmacy, Sinequan (10 mg) costs around $17 for 30 capsules without insurance. Fortunately, generic brands, such as doxepin, offer an affordable alternative.

  • How can I refill my Sinequan prescription?

    Sinequan is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Who should not take Sinequan?

    To make sure Sinequan is safe for you, tell your doctor if you have:

    • An allergic reaction to doxepin tablets

    • Urinary retention issues

    • Glaucoma

    • High blood sugar (diabetes)

  • How long before bed should you take Sinequan?

    Take Sinequan 30 minutes before bed when you're ready to sleep.

  • How long does it take for Sinequan to work?

    For most patients, it takes 2–3 weeks to experience the full effect of Sinequan.

  • Does Sinequan work the first night?

    If you have insomnia, doxepin may start working within the first few days to treat your symptoms. Most people notice the effects of Sinequan within 2–3 weeks.

  • What happens if I miss a dose of Sinequan?

    If you miss a dose of Sinequan, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Sinequan?

    If you've taken too much Sinequan, seek emergency medical attention or contact your local poison control center. Serious symptoms can occur.

3 simple steps to request your Sinequan prescription today 

Step 1: Book an appointment

Step 1

Book a Sinequan prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Sinequan prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Sinequan prescription.

We can send prescriptions to any local pharmacy.

Sinequan prescription pricing details

How pricing works

To get a new or refill on your Sinequan prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free

First visit


For all visits

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free

First visit


Repeats only $99

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129 and follow-ups are only $99 for active members.

Book an appointment

If we're unable to treat you, we'll provide a full refund.