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Chronic Care Heart Disease Management High Cholesterol
Chronic Care Heart Disease Management High Cholesterol

Repatha® prescription online

Repatha® (evolocumab) is a second-line treatment for high cholesterol, prescribed when lifestyle changes and statins aren’t enough. It’s an advanced therapy and it’s reserved for patients who meet specific medical criteria.
Second-line advanced cholesterol-lowering treatment. PCSK9 inhibitor therapy. Administered via injection.
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What is Repatha®?

Repatha® is a PCSK9 inhibitor, a class of medications designed to help lower LDL (bad) cholesterol levels by preventing the breakdown of LDL receptors in the liver. A greater number of active receptors enhances your body's ability to remove LDL cholesterol from the bloodstream, reducing overall levels.1

What is Repatha® used for?

Repatha® is prescribed for individuals who have tried more traditional high cholesterol treatment options and need additional help lowering their LDL levels, particularly those who: 

  • Have familial hypercholesterolemia (a genetic condition causing high cholesterol) 
  • Have atherosclerotic cardiovascular disease (ASCVD) 
  • Do not respond adequately to statin therapy alone1

  

Because Repatha® is an advanced treatment, it is not typically a first-line option and is usually prescribed only when other cholesterol-lowering methods have proven insufficient. 

Is Repatha® a statin?

Repatha® is not a statin. Statins work by reducing cholesterol production in the liver, while Repatha® helps the body remove LDL cholesterol more effectively. In many cases, Repatha® is prescribed in addition to a statin like Lipitor (atorvastatin) and Crestor (rosuvastatin) for maximum cholesterol reduction.1

Repatha® side effects

Common side effects

  • Cold or flu-like symptoms 
  • Injection site reactions (redness, pain, swelling) 
  • Back pain2

Serious side effects

  • Allergic reactions (rash, difficulty breathing, swelling) 
  • Severe muscle pain 
  • Confusion or memory issues3

What are the long-term side effects of Repatha®?

Long-term data on Repatha® suggests it is generally safe. However, some studies indicate a possible association with: 

  • Cognitive effects (such as memory issues, though rare) 
  • Increased risk of infections 
  • Potential impact on glucose levels (monitoring is recommended for people with diabetes)4 

 

If you experience severe side effects, contact a healthcare provider immediately. 

Repatha® injection: how it works

Repatha® is administered as a subcutaneous injection (under the skin) every two or four weeks, depending on your doctor’s recommendation. It comes in a pre-filled autoinjector or syringe, making it easy to self-administer at home.5 Common injection site locations include the thigh, abdomen or upper arm.

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Repatha® cost & copay assistance

Repatha® can be expensive, but there are cost-saving options available: 

  • Insurance coverage: Many plans cover Repatha®, though prior authorization may be required. 
  • Manufacturer copay programs: Eligible patients may qualify for savings through Amgen's Repatha® Copay Card. 
  • Pharmacy discount programs: Some pharmacies offer discounts through prescription savings plans.1

FAQs about Repatha®

How does Repatha® work differently from other cholesterol medications?

Unlike statins, which reduce cholesterol production, Repatha® works by increasing the liver’s ability to remove LDL cholesterol from the bloodstream. It is often prescribed alongside statins for better results.1

How long does it take for Repatha® to lower cholesterol?

Many patients see results within 2 to 4 weeks, with maximum LDL reduction achieved within 12 weeks of consistent use.4

Can Repatha® be taken with other cholesterol-lowering medications?

Yes. Repatha® is commonly prescribed alongside statins and other cholesterol-lowering medications for enhanced effectiveness.1

Can I stop taking Repatha® once my cholesterol levels improve?

Repatha® is a long-term treatment. Stopping the medication may lead to an increase in LDL cholesterol. Always consult your doctor before making changes to your treatment.4

Does Repatha® have any dietary restrictions?

No specific dietary restrictions are required, but maintaining a heart-healthy low cholesterol diet can enhance its effectiveness.1

What should I do if I miss a dose of Repatha®?

If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue as normal. Do not double up.6

Is Repatha® safe for people with diabetes?

Repatha® is generally considered safe for people with diabetes, but monitoring blood sugar levels is recommended, as some studies suggest it may slightly affect glucose metabolism.4

Talk to a doctor and get help with a referral today

Step 1 for an repatha referral
Step 1

Book an appointment with one of our top-rated doctors.

Book a same day appointment from nearly anywhere.
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Step 2

Talk to our doctors regarding Repatha® and your symptoms.

Because Repatha® is a second-line treatment, it is typically prescribed only for patients who meet strict medical criteria.
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Step 3

Receive the appropriate specialist referral.

Consult with us about prescriptions, treatments, and referrals if necessary.

Repatha® prescription referral details

Repatha® requires a referral, join our monthly membership and get discounted visits.

30 days of free membership

  • Same-day appointments 7 days a week
  • Unlimited messages with your Care Team
  • Prescription discount card to save up to 80%
  • Exclusive discounts on lab tests
  • Free memberships for your family
  • Cancel anytime

Paying with insurance

Membership

$19.99

First month free

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Visits

Copay

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

We accept these insurance plans and many more:


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Paying without insurance

Membership

$19.99

First month free

+

Visits

$129

Visit price without insurance

Initial visits are $129.
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*If we're unable to treat you, we'll provide a full refund. Please note that any medication or lab work costs are not included. Please refer to our refund policy for additional information.

Sources:

PlushCare is dedicated to providing you with accurate and trustworthy health information.

  1. Repatha® (evolocumab) – A PCSK9 Inhibitor for Lowering LDL-C. Accessed on March 20, 2025, at https://www.repatha.com/. 
  2. Repatha® Side Effects. Accessed on March 20, 2025, at https://www.repatha.com/repatha-side-effects. 
  3. Evolocumab (Subcutaneous Route) Description. Accessed on March 20, 2025, at https://www.mayoclinic.org/drugs-supplements/evolocumab-subcutaneous-route/description/drg-20152627. 
  4. Repatha (Evolocumab) Side Effects: What You Should Know. Accessed on March 21, 2025, at https://www.healthline.com/health/drugs/repatha-side-effects. 
  5. Dosing & Administration. Accessed on March 21, 2025, at https://www.repathahcp.com/dosing-and-administration. 
  6. Repatha® (evolocumab) Patient Information. Accessed on March 21, 2025, at https://www.pi.amgen.com/united_states/repatha/repatha_ppi_pt_english.pdf. 




PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.