Onglyza (saxagliptin) prescription available online

If you are suffering from type 2 diabetes mellitus, Onglyza can help. Get a new prescription or refill of Onglyza today from a board-certified doctor online.*

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FDA-approved to treat type 2 diabetes mellitus

Available as a tablet

Not effective for treating type 1 diabetes

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Onglyza (saxagliptin)

Onglyza is considered a dipeptidyl peptidase-4 (DPP-4) inhibitor, which works by increasing the amount of insulin produced by the body after meals when blood sugar is high.

Onglyza is used for glycemic control in patients with type 2 diabetes mellitus. Onglyza is available only by prescription. It is available in a generic formulation as well as under different brand names, including saxagliptin.

Onglyza may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Onglyza, be sure to complete the full course of the diabetes medication unless your doctor specifically tells you to stop. If you don’t complete your prescription, the diabetes medication may not fully treat your type 2 diabetes mellitus.

Onglyza uses

There is one FDA-approved use for Onglyza, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons.

It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Type 2 diabetes mellitus

    Onglyza is FDA-approved to treat type 2 diabetes mellitus in combination with diet and exercise. Onglyza is sometimes prescribed with other diabetes medications to manage high blood sugar.

    Onglyza is not effective for treating type 1 diabetes or diabetic ketoacidosis.

Onglyza side effects

  • The side effects associated with taking Onglyza are typically mild. Most Onglyza side effects are associated with cold symptoms. Onglyza has some common side effects. They may include:

    • Upper respiratory tract infection symptoms, such as sore throat or stuffy nose

    • Painful urination

    • Headache

    • Swelling in the hands or feet

    Other side effects, which are less common but might be more severe, could include:

    • Severe joint pain

    • Heart problems, such as shortness of breath or unusual tiredness

    • Burning sensation during urination

    Tell your doctor if you notice any of these side effects. Ask your doctor for medical advice if you develop any other new or concerning symptoms. The use of Onglyza in children under age 18 is not recommended.

How to take Onglyza

Your pharmacist will provide you with instructions on how to take your Onglyza prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Onglyza can come in different forms and doses, so be sure to follow the specific instructions on your prescription. For adults with type 2 diabetes, the starting saxagliptin dose typically ranges from 2.5 mg to 5 mg orally once daily, with or without food.

What to avoid while taking Onglyza

Onglyza has 377 drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Onglyza include:

Drinking alcohol while taking Onglyza can increase the risk of high blood sugar (hyperglycemia) and low blood sugar (hypoglycemia), depending on how much you drink. Ask your doctor for medical advice about side effects before drinking alcohol.

Medication alternatives to Onglyza

If your healthcare provider prefers to put you on another treatment, they may suggest another oral diabetes medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Onglyza prescription FAQs

  • How much does Onglyza cost?

    Depending on your pharmacy, Onglyza costs around $505 for thirty 2.5 tablets without insurance. Fortunately, generic brands, such as saxagliptin, offer an affordable alternative.

  • How can I refill my Onglyza prescription?

    To refill your Onglyza prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Onglyza?

    Avoid taking Onglyza if you have certain medical conditions, such as:

    • Kidney disease

    • Heart failure

    • Pancreatitis

    • Gallstones

    • Alcoholism

    • High triglycerides

    • Serious allergic reactions to insulin products

  • What is the best time to take Onglyza?

    You can take Onglyza at any time of the day, but it's best to take Onglyza before or after a meal. Take your saxagliptin dose at the same time each day to effectively treat high blood sugar.

  • Can you take Onglyza and metformin together?

    Yes, Onglyza and metformin can be safely taken together. Your doctor may prescribe saxagliptin and metformin to treat high blood sugar (blood glucose) levels.

    Your doctor may recommend regular blood sugar testing to make sure both medications are safe for you.

  • What happens if I miss a dose of Onglyza?

    If you miss a dose of Onglyza, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose and return to your regular dosing schedule. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much Onglyza?

    If you've taken too much Onglyza, seek emergency medical attention or contact your local poison control center. You may have signs of severe hypoglycemia (low blood sugar), such as weakness, rapid breathing, sweating, or lightheadedness.

3 simple steps to request your Onglyza prescription today 

Step 1: Book an appointment

Step 1

Book a Onglyza prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Onglyza prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Onglyza prescription.

We can send prescriptions to any local pharmacy.

Onglyza prescription pricing details

How pricing works

To get a new or refill on your Onglyza prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.