Humulin N (Human Recombinant) prescription available online

If you are suffering from Type 1 or Type 2 diabetes, Humulin N can help. Get a new Humulin N prescription or refill today from a board-certified doctor online.*

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FDA-approved for type 1 and type 2 diabetes

Intermediate-acting insulin for diabetes

Manage diabetes with Humulin N

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Humulin N 

Humulin N is considered intermediate-acting insulin, which functions by helping to keep your blood sugar levels from getting too high blood sugar after you eat. Like any insulin, this medication can only be used to manage diabetes. It is ineffective against any other condition because it will not reduce blood sugar levels in people who do not have diabetes mellitus.

Some conditions that Humulin N is known to treat include type 1 and type 2 diabetes.

Humulin N is available only by prescription. It is available in a generic formulation under different brand names, including prefilled Humulin® N KwikPen® or in a Humulin N U-100 vial.

Humulin N may be prescribed as an injection only or as an injection with a pump. It's always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Humulin N, be sure to complete the full course of the medication unless your doctor specifically tells you to stop.

If you don't complete your prescription, the insulin may not fully treat your diabetes, and your blood sugar levels may become difficult to manage. Use Humulin N properly.

Humulin N uses

There are two FDA-approved uses for Humulin N, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It's also possible that your healthcare provider may prescribe it for other reasons not listed here. Talk with your doctor or pharmacist if you have questions about why a medication is prescribed.

  • Manage type 1 and type 2 diabetes

    Humulin N is primarily used to help keep your blood sugar levels from getting too high after you eat. It's always important to follow the dosing schedule prescribed by your doctor, as this will vary based on the formulation and dosage you are prescribed.

  • Manage diabetic ketoacidosis (DKA)

    Humulin N may also be used to help treat diabetic ketoacidosis (DKA), a serious complication of diabetes that can be life-threatening. If you have DKA, your blood sugar levels become too high, and your body starts to produce ketones. These ketones build up in the blood and can cause your blood to become acidic.

Humulin N side effects

  • The side effects associated with taking Humulin N are typically mild. Most Humulin N allergic reactions are associated with the injection sites. Humulin N has some common side effects. They may include:

    • Allergic reaction

    • Peripheral edema

    • Lipodystrophy

    • Localized cutaneous amyloidosis

    • Weight gain

    • Immunogenicity

    Other side effects, which are less common but might be more severe, could include:

    • Serious allergic reaction

    • Hypoglycemia 

    • Hypersensitivity reactions

    • Hypokalemia

    You should call your doctor if you notice any of these side effects or if you develop any other new or concerning symptoms. Using Humulin N in people with low blood potassium, low blood sugar, reduced kidney function, or liver problems is not recommended.

How to take Humulin N

Your pharmacist will provide you with instructions on how to take your Humulin N prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Humulin N can come in different forms and doses, so follow the specific instructions on your prescription. It is typically prescribed either once or twice per day, before mealsSome specific instructions may include a change in diet or exercise, but always follow your doctor's schedule.

Be sure to clean the injection site with rubbing alcohol before each insulin dose. Changing where you inject each time is important to lessen the risk of problems or damage under the skin. Inject the insulin into the upper arm, stomach area or the thigh, changing the injection site every time.

The insulin should be clear and colorless. Do not inject the Humulin N if it is discolored or contains particles.

Remember not to share your pen device with another person, even if the needle is changed.

What to avoid while taking Humulin N

Humulin N has four drug interactions. Don't change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

It is important to adjust the dose of these drugs when taking Humulin N. Some of these drugs should not be taken together.

Ask your doctor or pharmacist if consuming alcohol while taking Humulin N is acceptable.

Some research shows that regular alcohol consumption may decrease the effectiveness of Humulin N.

Alcohol may also reduce the medication's ability to do its job, making it harder to control your blood sugar levels. You should avoid drinking alcohol while taking this medication.

Medication alternatives to Humulin N

If your healthcare provider prefers to put you on another treatment, they may suggest another insulin. Here are some common doctor-recommended alternatives based on your health issue:

Humulin N prescription FAQs

  • How much does Humulin N cost?

    Humulin N costs $18.82 for 3 milliliters. Humulin N vials are a long-acting, man-made form of insulin human injection. It works by lowering blood sugar levels in patients with diabetes mellitus.

  • How can I refill my Humulin N prescription?

    Follow the instructions for refilling your Humulin N prescription from your healthcare provider. You can refill your Humulin N prescription online with PlushCare.

    Our doctors can refill your prescription online if you qualify. Simply book an appointment with one of our doctors, attend the visit with one of our clinicians on your phone or computer, and then they can electronically send a refill to your nearest pharmacy.

  • What kind of insulin is Humulin N?

    Humulin N is an intermediate-acting insulin that is made with recombinant DNA technology using human insulin and is available in three strengths: 100 units/mL (U-100), 300 units/mL (U-300), and 500 units/mL (U-500).

  • What is equivalent to Humulin N?

    Humulin N is a human insulin product equivalent to Novolin N, a human insulin product.

  • What is the difference between Humulin N and Humulin R?

    The difference between Humulin N and Humulin R is that Humulin N is basal insulin, which keeps blood sugar levels steady over a long period. Humulin R is a quick-acting insulin that peaks within 2 hours and lasts for about 4 hours.

  • When should Humulin N be given?

    Humulin N should be given around the same time every day, preferably in the morning. It can be injected under the skin (subcutaneously) or into a vein (intravenously).

  • Who should not take Humulin N?

    People should not take Humulin N with hypersensitivity to insulin detemir or any of the excipients or those with diabetic ketoacidosis. It should also not be used during episodes of severe hypoglycemia. It can reduce your blood glucose levels.

  • What happens if I miss a dose of Humulin N?

    First, call your doctor for medical advice. Typically, they may recommend that if you miss a Humulin N dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Humulin N at the same time.

  • What happens if I take too much Humulin N?

    If you take too much insulin dose, your blood sugar could drop too low. This could lead to dizziness, blurred vision, shakiness, sweating, confusion, and loss of consciousness.

    Seek emergency medical attention if you have any of these symptoms. Use frequent blood glucose monitoring to detect your sugar levels. Use glucose tablets or other drugs to increase blood sugar levels.

3 simple steps to request your Humulin N prescription today 

Step 1: Book an appointment

Step 1

Book a Humulin N prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Humulin N prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Humulin N prescription.

We can send prescriptions to any local pharmacy.

Humulin N prescription pricing details

How pricing works

To get a new or refill on your Humulin N prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Humulin N prescription resources


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.