Dupixent for Eczema: How it works, alternatives, and help with referrals

What is Dupixent?

Dupixent (dupilumab) is an FDA-approved prescription medication that is primarily used to treat moderate to severe eczema, or atopic dermatitis, in adults and children ages 6 months and older.^{1, 2, 3} Dupixent comes in the form of a liquid solution that is self-administered via subcutaneous injections every one to four weeks.¹ It can also be prescribed to treat eosinophilic or oral-corticosteroid-dependent asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), and prurigo nodularis.^{1, 2, 3}

We do not currently prescribe Dupixent, but our board-certified online doctors are happy to discuss other personalized treatment options with you.

Who is a candidate for Dupixent?

The FDA has approved Dupixent (dupilumab) in adults and children 6 months old and up who have moderate to severe eczema that has not improved with the use of topical medications, or where topicals are contraindicated.^{1, 3, 6}

When treating moderate to severe asthma, Dupixent can be prescribed to adults and children aged 6 years and older; for eosinophilic esophagitis (EoE), it can be used in people ages 1 year and up, and for chronic rhinosinusitis, people 12 years of age and older can use Dupixent.^{3, 5} Only adults 18 and up may be prescribed Dupixent for the treatment of COPD or prurigo nodularis.^{3, 6}

How does Dupixent for eczema work?

Atopic dermatitis, more commonly known as eczema, is a chronic (recurring) condition characterized by inflamed, red, dry, itchy patches on the skin, usually in response to allergens or other irritants.⁴

Dupixent works as an antagonist to inflammatory proteins in the immune system—interleukin-4 (IL-4) and interleukin-13 (IL-13)—which means that it blocks these proteins from being overactive.^{1, 5} By blocking IL-4 and IL-13, Dupixent also lowers other inflammatory substances in the immune system, such as cytokines, chemokines, nitric oxide, and immunoglobulin E.^{5, 6} Through this mechanism of action, Dupixent reduces the chronic symptoms of eczema.^{1, 2, 3}

Dupixent injection: how it is administered

Dupixent is an injectable solution that is typically self-administered under the skin (subcutaneously) by the patient or an adult caretaker.^{1, 2, 3} The medication comes in the form of pre-filled pens or syringes with either a 200mg or 300mg dose.^{1, 2, 6} When your doctor first prescribes Dupixent, they will teach you how to inject yourself and how often to take it depending on your condition and its severity.^{1, 2, 6} For eczema, after an initial dose of 600mg, the usual dosage is 300mg every other week in adults and children ages 12 and up.^{2, 6}

Dosage of Dupixent when used in children <12yo varies and is dependent on weight.

How long does it take for Dupixent to start working for eczema?

When treating moderate to severe atopic dermatitis, Dupixent typically begins decreasing symptoms within 2 to 4 weeks, with relief continuing for patients who take it long-term.^{5, 7} In one clinical trial, about half of participants saw their symptoms improve by at least 75% over the course of 16 weeks.⁵

Dupixent side effects and risks

Like any prescription medication, using Dupixent may bring with it some adverse side effects and risks. If you experience any of these reactions, you can always contact your doctor to discuss.

Common side effects

The most common side effects associated with taking Dupixent (dupilumab) include^{1, 2, 6, 7}

Redness or swelling at the injection site

Cold-like symptoms (upper respiratory infections)

Eye or eyelid swelling or redness

Eosinophilia (increased white blood cell count)

Nausea or diarrhea

Cold sores

Rashes on the face

Additionally, while weight gain is not listed as an official side effect, some patients taking Dupixent have reported an increase in body weight.^{1, 6}

Less common but serious side effects

In some cases, severe side effects can occur when taking this medication. If you begin taking Dupixent and experience a serious allergic reaction marked by anaphylaxis, severe rashes, hives, vomiting, dizziness, fainting, fever, or difficulty breathing, you should get emergency medical care immediately by dialing 911.¹

You should also discuss with your doctor if you experience changes in your vision, eye infection, fever, chest pain, aching joints, or numbness.¹

Alternatives to Dupixent for eczema

There are many prescription medications that can treat eczema. Your doctor may recommend topical medications, such as the corticosteroid prescriptions Desonate (desonide) or Lidex (fluocinonide).⁸ Other commonly prescribed medications include antibiotics to control infections, pills that manage inflammation, or injectable biologics similar to Dupixent.⁸

At PlushCare, our top-rated online doctors cannot prescribe Dupixent at this time, but we are here to discuss your eczema symptoms and develop a personalized treatment plan.

FAQs about Dupixent for eczema

Can Dupixent cure eczema?

No, Dupixent does not cure eczema. It helps manage and reduce symptoms by targeting specific inflammatory pathways in the immune system. While many patients experience significant relief, eczema is a chronic condition that requires ongoing management.

Is Dupixent covered by insurance?

Many insurance plans cover Dupixent, but coverage varies depending on your provider and policy. You may need prior authorization from your doctor, and co-pays or deductibles may apply. Check with your insurance provider for specific details.

Can Dupixent be used for children with eczema?

Yes, the FDA has approved Dupixent for children as young as 6 months old who have moderate to severe eczema that hasn’t improved with topical treatments. The dosage and frequency may differ based on age and weight.

Does Dupixent interact with other medications?

Dupixent is not known for having significant drug interactions, but it is important to inform your doctor about all medications, supplements, or treatments you are using to ensure there are no potential conflicts.

Can Dupixent be used with other eczema treatments?

Dupixent can be used alongside topical medications, such as corticosteroids, when treating eczema.1 You should always be sure to discuss any medications you use with your doctor before starting Dupixent or any other prescription drug.

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Sources:

PlushCare is dedicated to providing you with accurate and trustworthy health information.

Drugs.com. Dupixent (Dupilumab) Drug Information. Accessed on February 20, 2025, at https://www.drugs.com/dupixent.html.
Mayo Clinic. Dupilumab (Subcutaneous Route) Description. Accessed on February 20, 2025, at https://www.mayoclinic.org/drugs-supplements/dupilumab-subcutaneous-route/description/drg-20406153.
Dupixent Official Website. What is Dupixent? Accessed on February 20, 2025, at https://www.dupixent.com/.
Mayo Clinic. Atopic Dermatitis (Eczema): Symptoms and Causes. Accessed on February 20, 2025, at https://www.mayoclinic.org/diseases-conditions/atopic-dermatitis-eczema/symptoms-causes/syc-20353273.
PubMed Central (PMC). Dupilumab for the Treatment of Atopic Dermatitis. Accessed on February 22, 2025, at https://pmc.ncbi.nlm.nih.gov/articles/PMC6110636/.
Drugs.com. How Does Dupixent Work? Accessed on February 22, 2025, at https://www.drugs.com/medical-answers/dupixent-work-3545366/.
Drugs.com. How Fast Does Dupixent Work? Accessed on February 22, 2025, at https://www.drugs.com/medical-answers/fast-dupixent-work-3545855/.
Mayo Clinic. Atopic Dermatitis (Eczema): Diagnosis and Treatment. Accessed on February 20, 2025, at https://www.mayoclinic.org/diseases-conditions/atopic-dermatitis-eczema/diagnosis-treatment/drc-20353279.

PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.

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What is Dupixent (dupilumab) and how it works for eczema