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Ryan Quinn

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About Author — Ryan has a background in geochemical research and enjoys writing on technical subjects like health and science. He lives in Salt Lake City, UT and can be found recreating in the local mountains.

Most PlushCare articles are reviewed by M.D.s, Ph.Ds, N.P.s, nutritionists and other healthcare professionals. Click here to learn more and meet some of the professionals behind our blog.

Can You Buy Wellbutrin Online?

The original Wellbutrin was discontinued in the U.S. and has since been rebranded as Wellbutrin SR and Wellbutrin XL, which you can get prescriptions for and buy online.

To get a Wellbutrin prescription online, you can book an online appointment with PlushCare.

One of our top U.S. doctors can write or refill a prescription online and send it electronically to a pharmacy of your choice. Of course, your PlushCare doctor will evaluate your condition and determine whether or not Wellbutrin is right for you before writing or refilling a prescription.  

When purchasing Wellbutrin online, be cautious of scam pharmacies. They might rob you or sell you a dangerous product. Doctors at PlushCare can help point you in the right direction. The FDA also has a guide for selecting an online pharmacy.

What is Wellbutrin?

Wellbutrin is a brand name of bupropion, a type of antidepressant. Usually, Wellbutrin is marketed as a depression treatment, but it is also effective for treating smoking cessation and seasonal affective disorder.

To read more about bupropion click here.

There are many types of antidepressants; Wellbutrin is a norepinephrine and dopamine reuptake inhibitor (NDRI).

Wellbutrin SR vs. Wellbutrin XL

Wellbutrin SR is a sustained-release tablet whereas Wellbutrin XL is an extended-release tablet. The speeds at which they dissolve in the body are different. Because of this, they have some different side effects, strengths, and uses.

How does Wellbutrin work?

Neurotransmitters (such as serotonin, norepinephrine, and dopamine) deliver a signal by traveling between nerve cells in the brain. Normally after the message is delivered, the neurotransmitter is reabsorbed by nerve cells (a process called reuptake). When reuptake inhibitor medications are taken, the neurotransmitters are prevented from being reabsorbed, and instead, they remain in the synapse (the space between nerve cells).

Most antidepressants target the serotonin neurotransmitter, such as fluoxetine (Prozac) and venlafaxine (Effexor). Wellbutrin inhibits the reuptake of norepinephrine and dopamine.

Wellbutrin dosage and treatment

Take Wellbutrin as directed by your doctor. For people who suffer from acute episodes of depression, long term medication (several months or longer) is still recommended.

Initial doses

  • Wellbutrin SR: 150 mg/day taken as one dose in the morning. This phase usually lasts three days.
  • Wellbutrin XL: 150 mg/day taken as one dose in the morning. This phase usually lasts four days.

Maintenance doses

  • Wellbutrin SR: 150 mg taken twice daily. Doses should be taken eight hours apart.
  • Wellbutrin XL: 300 mg taken as one dose in the morning.

Maximum doses

  • Wellbutrin SR: 200 mg taken twice daily.
  • Wellbutrin XL: 400 mg taken as one dose in the morning.
  • Maximum doses for treating smoking cessation and seasonal affective disorder are 300 mg/day.

Benefits of Wellbutrin

Wellbutrin is effective in treating depression. Usually, depression symptoms decrease within the first couple of weeks, but the full effect can take up to 8 weeks.

Wellbutrin also is effective in reducing symptoms of nicotine withdrawal and can also be used alongside other smoking cessation medications such as the patch.

Side effects of Wellbutrin

Antidepressant drugs, including Wellbutrin, can increase suicidal thoughts and behavior. This is more likely to affect people under the age of 24.

The most common side effects of Wellbutrin:

  • Insomnia (45%)
  • Headache (34%) or migraine (26%)
  • Agitation (32%)
  • Weight loss (28%)
  • Dry mouth (28%)
  • Constipation (26%)
  • Nausea (23%)
  • Vomiting (23%)
  • Excessive sweating (22%)
  • Dizziness (22%)
  • Tremor (21%)
  • Sedation (20%)
  • Blurred vision (15%)
  • Nasopharyngitis (13%)
  • Abnormal dreams (13%)
  • Rhinitis (12%)
  • Irregular heart beat (11%)

Call your doctor if you experience any of these common side effects of Wellbutrin:

  • Seizures
  • Manic episode
  • Changes in vision
  • Anxiety
  • Dry mouth
  • Hyperventilation
  • Fast or irregular heartbeat
  • Irritability
  • Restlessness
  • Shaking
  • Trouble sleeping

This is not a complete list of all side effects. If you experience any troublesome side effects not listed here, speak with your doctor.

Side effects of Wellbutrin SR vs. Wellbutrin XL

The side effects of the two Wellbutrin formulations are mostly the same, but there are some differences. Wellbutrin SR can cause a ringing in the ears, and Wellbutrin XL can cause changes to the frequency of urination.

Considerations and precautions of Wellbutrin

Drug interactions

There are 402 drugs known to interact with Wellbutrin, over half of these are severe. Be sure to discuss with your doctor any medications or supplements that you are taking, have recently taken, or will be taking shortly.

  • MAO inhibitors are sometimes used as an antidepressant. Do not take Wellbutrin 14 days before or after an MAO inhibitor.
  • Do not take Wellbutrin if you have suddenly stopped using alcohol, seizure medication, or a sedative.

Disease interactions

Wellbutrin may be dangerous for people with certain conditions. Be sure to tell your doctor if you have:

  • A seizure disorder
  • An eating disorder
  • Liver disease


It is unknown if Wellbutrin will harm an unborn baby, but it does pass into breast milk. Talk with a doctor before using this medication if you are pregnant or breastfeeding.

Get Wellbutrin Online

To talk to a doctor about whether Wellbutrin can you help you, click here. You can discuss your symptoms with a physician and they can recommend treatment options including psychiatric care and prescribe medication including Wellbutrin.

Getting a prescription for Wellbutrin has never been more convenient. Try an online consultation today. The average appointment lasts just 15 minutes and 97% of patients are treated on the first visit.

PlushCare takes content accuracy seriously so we can be your trusted source of medical information. Most articles are reviewed by M.D.s, Ph.D.s, NPs, or NDs. Click here to meet the healthcare professionals behind the blog.

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