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Leah McCabe

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About Author — Leah likes writing about health and science subjects. Through her writing she hopes to help people of all backgrounds have equal access to information and quality healthcare.

Most PlushCare articles are reviewed by M.D.s, Ph.Ds, N.P.s, nutritionists and other healthcare professionals. Click here to learn more and meet some of the professionals behind our blog. The PlushCare blog, or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment. For more information click here.

Can You Buy Bupropion Online?

If you want to get a bupropion prescription online, all you have to do is book an appointment with PlushCare.

One of our top U.S. doctors can write or refill a prescription online and send it electronically to a pharmacy of your choice. Of course, your PlushCare doctor will evaluate your condition and determine whether or not a bupropion prescription is right for you before writing or refilling a prescription.  

If you are prescribed bupropion, you can pick it up at an in-store location or buy bupropion online. Take caution while purchasing prescription medications online because there are many scam-pharmacies online that will rob you or worse, damage your health.

Fortunately, there are reputable sites like PlushCare where you can talk to a doctor through an online appointment. If your doctor decides bupropion is appropriate for you, they can help you choose a trustworthy online pharmacy. The FDA has a guide for selecting an online pharmacy. Bupropion should be approximately $0.62 per unit. If you find it substantially cheaper than that, it may be fake.

What is bupropion?

Bupropion is a type of antidepressant that is prescribed for the treatment of depression, seasonal affective disorder, and smoking cessation. There are many types of antidepressants; bupropion is a norepinephrine and dopamine reuptake inhibitor (NDRI).

Bupropion is a generic drug sold under various brand names. They are usually marketed for depression or smoking cessation, but they are the same drug:

How does bupropion work?

Neurotransmitters are released in the brain to deliver messages between nerves. After the message is delivered, the neurotransmitters are usually reabsorbed by nerve cells. When reuptake inhibitors are taken, those neurotransmitters are prevented from being reabsorbed, and instead, they remain in the synapse (the space between nerve cells).

Most antidepressants target the serotonin neurotransmitter, such as fluoxetine (Prozac) and venlafaxine (Effexor). Bupropion inhibits the reuptake of norepinephrine and dopamine.

Bupropion dosage and treatment

To minimize the side effects of bupropion, patients usually start with an initial dose that is increased if the desired result is not achieved. The maximum dose for sustained-release tablets is 400 mg per day, and 200 mg for single-dose. The maximum dose for immediate-release and extended-release tablets is 450 mg per day. Different bupropion medications should not be taken simultaneously to treat both depression and smoking cessation at the same time.

Bupropion and smoking cessation

Because bupropion has little effect for the first week or two, start taking bupropion one to two weeks before your quit date. For most patients, bupropion is only taken 7 to 12 weeks. If the quit attempt was not successful at that point, bupropion usage is most commonly discontinued.

Maximum dosages of bupropion for smoking cessation are 300 mg per day.

Bupropion and seasonal affective disorder

Begin taking bupropion in the fall and continue through the winter. Reduce the dose when spring is nearing and discontinue usage in early spring.

Benefits of bupropion

Bupropion is effective in treating depression. Usually, depression symptoms decrease within the first couple of weeks, but the full effect can take up to 8 weeks.

Bupropion also is effective in reducing symptoms of nicotine withdrawal can also be used alongside other smoking cessation medications such as the patch.

Side effects of bupropion

Severe allergic reactions to drugs are possible. Seek emergency care if you experience hives; rash; difficulty breathing, or swelling of the face, mouth, tongue, or throat.

Antidepressant drugs, including bupropion, can increase suicidal thoughts and behavior. This is more likely to affect people under the age of 24.

The most common side effects of bupropion:

  • Insomnia (45%)
  • Headache (34%) or migraine (26%)
  • Agitation (32%)
  • Weight loss (28%)
  • Dry mouth (28%)
  • Constipation (26%)
  • Nausea (23%)
  • Vomiting (23%)
  • Excessive sweating (22%)
  • Dizziness (22%)
  • Tremor (21%)
  • Sedation (20%)
  • Blurred vision (15%)
  • Nasopharyngitis (13%)
  • Abnormal dreams (13%)
  • Rhinitis (12%)
  • Irregular heart beat (11%)

Call your doctor if you experience any of these common side effects of bupropion:

  • Seizures
  • Manic episode
  • Changes in vision
  • Anxiety
  • Dry mouth
  • Hyperventilation
  • Fast or irregular heartbeat
  • Irritability
  • Restlessness
  • Shaking
  • Trouble sleeping

This is not a complete list of all side effects. If you experience any troublesome side effects not listed here, speak with your doctor.

Considerations and precautions of bupropion

Drug interactions

There are 402 drugs known to interact with bupropion, over half of these are severe. Be sure to discuss with your doctor any medications or supplements that you are taking, have recently taken, or will be taking shortly.

  • MAO inhibitors. Do not take bupropion 14 days before or after an MAO inhibitor.
  • Do not take bupropion if you have suddenly stopped using alcohol, seizure medication, or a sedative.

Disease interactions

Bupropion may be dangerous for people with certain conditions. Be sure to tell your doctor if you have:

  • A seizure disorder
  • An eating disorder
  • Liver disease


It is unknown if bupropion will harm an unborn baby, but it does pass into breast milk. Talk with a doctor before using this medication if you are pregnant or breastfeeding.

Get Bupropion Online

To talk to a doctor about whether bupropion can you help you, click here. You can discuss your symptoms with a physician and they can recommend treatment options including psychiatric care and prescribe medication including bupropion.

Getting a prescription for bupropion has never been more convenient. Try an online consultation today. The average appointment lasts just 15 minutes and 97% of patients are treated on the first visit.

PlushCare takes content accuracy seriously so we can be your trusted source of medical information. Most articles are reviewed by M.D.s, Ph.D.s, NPs, or NDs. Click here to meet the healthcare professionals behind the blog.

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