Yupelri® (revefenacin) nebulizer prescription available online

Yupelri® is taken using a nebulizer, a device that converts liquid medicine into a mist for inhalation.³  After inserting the medicine into the reservoir of the nebulizer, breathe evenly for approximately eight minutes using the nebulizer mouthpiece.³  The nebulization process is complete when no mist remains in the device.  

By helping to relax the muscles around the airways in your lungs, once-daily Yupelri® prevents symptoms such as shortness of breath, cough, and chest tightness.^{1, 2} Do not stop taking Yupelri® suddenly and without consulting a doctor, as this could worsen your symptoms.¹ 

The typical recommended Yupelri® dosage for maintenance treatment of COPD is one (1) viral by oral inhalation once daily.⁴  Each vial of Yupelri® contains 175 micrograms (mcg) per 3 millimeters (mL) of solution.⁴ Do not mix Yupelri® with other medications in the nebulizer cup (reservoir).¹  

Yupelri® nebulizer solution is a long-acting muscarinic antagonist (LAMA) used for the maintenance treatment of COPD, including chronic bronchitis and emphysema. It helps relax the muscles around the airways, making breathing easier. It is not a rescue medication for sudden breathing problems but is intended for once-daily use to improve lung function over time. 

The average cost for Yupelri® (175 mcg/3 mL) inhalation solution is $1,655 for a 90-milliliter supply. Quoted costs for uninsured customers vary by pharmacy.⁷ If you do not have insurance, or your insurance does not cover Yupelri®, you may be eligible for Yupelri®’s Patient Assistance Program. PlushCare also offers a Prescription Discount Card in partnership with SingleCare, which can save you up to 80% on costs associated with medication.  

Yupelri® is a daily, long-term treatment for the maintenance of COPD and may be prescribed by itself or with other COPD drugs. Examples of other COPD drugs that may be used with Yupelri® include salmeterol (Serevent) and fluticasone/vilanterol (Breo Ellipta).⁸

COPD is caused by inflammation in the lungs that results in airway blockage, characterized by difficulty breathing, wheezing, and a cough accompanied by mucus.¹⁰ Yupelri® is a bronchodilator, a class of drugs that work by relaxing and widening the airways. Alternatives to Yupelri® include other long-acting muscarinic antagonists (LAMAs), combination inhalers, and short-acting beta antagonists, such as Spiriva, Atrovent, and ProAir HFA^10,13,14. Discuss your individual needs and preferences with your healthcare provider before beginning treatment. 

 Yupelri® is considered safe for long-term use when taken as prescribed for COPD maintenance therapy.¹¹ Speak with your healthcare provider to determine if Yupelri® is safe and effective for your condition before using Yupelri®.  

Yupelri® starts to work in as little as five minutes after the inhalation of the medication. The greatest impact of Yupelri® on lung function typically occurs within two hours. Because Yupelri® is a maintenance medication, it is important that you take it daily to prevent COPD symptoms from worsening.¹² If you miss a dose, take the medication as soon as possible. If it is time for your next dose, skip the missed dose.¹ 

Before using Yupelri®, tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. It is not yet known if Yupelri® may harm your unborn baby or pass into your breastmilk.² 

Does Yupelri® nebulizer interact with other medications?  

Always tell your healthcare provider about any other medications that you are taking. Be sure to discuss if you are using^{1, 6} 

• Anticholinergic medicines 

• Other long-acting muscarinic antagonist (LAMA) medicines 

• Medicine to suppress your immune system (Cyclosporine  

• Medicine to treat tuberculosis (Rifampin) 

• Medicine to treat depression, anxiety, mood disorders, or mental illness 

• Cold or allergy medicine 

• Medicine to treat Parkinson's disease 

• Medicine to treat stomach problems or irritable bowel syndrome 

• Medicine to treat overactive bladder 

• Bronchodilator asthma medication  

Yupelri® should not be used if you have a history of liver disease. It has also not been studied in patients with end-stage kidney disease. If you have either of these, be sure to discuss them with your doctor when deciding which medication is right for you.