Xylocaine (lidocaine) prescription available online 

If you are suffering from pain or discomfort, Xylocaine (lidocaine) can help. Get a new prescription or refill of lidocaine from a board-certified doctor online.*

Book an appointment

Treats skin irritations, burns, hemorrhoids, and more

Available as injection, topical solution, or patch

Local anesthetic for pain reduction

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Xylocaine (lidocaine)

Lidocaine is considered a local anesthetic (numbing medication), which numbs an area of the body to help reduce pain or discomfort.

Lidocaine can help reduce pain associated caused by skin irritations, minor burns, hemorrhoids, and other skin problems. Lidocaine is available only by prescription. It is available in a generic formulation as well as under different brand names, including Xylocaine.

Lidocaine may be prescribed as an injection, lidocaine topical solution, or lidocaine patch. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed lidocaine, be sure to complete the full course of the local anesthetic agent unless your doctor specifically tells you to stop. If you don’t complete your prescription, the local anesthetic agent may not fully treat your pain or discomfort.

Xylocaine (lidocaine) uses

There are several FDA-approved uses for lidocaine, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your doctor may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Local anesthetic

    Lidocaine is FDA-approved to treat pain and discomfort. It may be used as a topical solution.

    Lidocaine hydrochloride is sometimes prescribed to treat irregular heart rhythms that may signal a heart attack. It's also given as an epidural to reduce the discomfort of contractions during labor.

Lidocaine side effects

The side effects associated with taking lidocaine are typically mild. Most Lidocaine side effects are associated with drowsiness. Lidocaine has some common side effects. They may include:

    • Drowsiness or dizziness

    • Nausea, vomiting, or upset stomach

    • Numbness in areas where the topical solution is accidentally applied

    Other side effects, which are less common but might be more severe, could include:

    • Twitching, tremors, or seizures

    • Slow heartbeat or slow pulse

    • Trouble breathing

    You should call your doctor if you notice any adverse reactions, or if you develop any other new or concerning symptoms. Lidocaine should only be used in children over the age of three when other drugs cannot be used. Avoid using local anesthetics to treat infants with teething pain.

How to take lidocaine

Your pharmacist will provide you with instructions on how to take your lidocaine prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Lidocaine can come in different dosage forms and doses, so be sure to follow the specific instructions on your prescription. When using lidocaine topical, use the smallest amount of medicine needed to treat pain. Your body may absorb too much lidocaine hydrochloride if you use too much.

What to avoid while taking lidocaine

Lidocaine has 49 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as other drugs. 

Possible drug interactions with lidocaine HCl include:

  • Benadryl (diphenhydramine)

  • Vitamin B12, vitamin C, and vitamin D3

  • Voltaren Arthritis Pain Gel (diclofenac topical)

  • Tylenol (acetaminophen)

  • Low-strength aspirin

Ask your doctor for medical advice before drinking alcohol. Because local anesthetics can stay in your system for up to 24 hours after the numbing effect wears off, drinking alcohol is not recommended.

Avoid using lidocaine or other local anesthetics for teething pain in infants and children.

Medication alternatives to lidocaine

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other local anesthetic agents in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Pain and discomfort

    Dermoplast (benzocaine)

    Prax (pramoxine)

    Ametop gel (tetracaine)

Lidocaine prescription FAQs

  • How much does lidocaine cost?

    Depending on your pharmacy, lidocaine ointment costs around $20 for 35.44 grams without insurance. Lidocaine is a generic brand, and brand names may cost more.

  • How can I refill my lidocaine prescription?

    Lidocaine is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Where should you not apply lidocaine?

    Avoid applying lidocaine HCl to swollen skin or deep puncture wounds. Don't use the medication on raw or blistered skin.

  • What happens if you leave lidocaine on too long?

    If you leave lidocaine on for too long, the local anesthetic agent can absorb into your skin, leading to skin irritation. Rarely, lidocaine can cause serious side effects, such as heart rhythm problems and respiratory depression.

  • What kind of pain is lidocaine good for?

    Topical lidocaine is used to reduce pain or discomfort caused by skin irritations. It can help treat pain associated with sunburn, insect bites, minor burns, and scratches.

  • How long does lidocaine last once applied?

    Lidocaine typically numbs the affected area for 30 minutes to three hours once applied.

  • Who should not take lidocaine?

    To make sure lidocaine is safe for you, tell your doctor if you have:

    • Severe heart block

    • A heart rhythm disorder, such as Stokes-Adams syndrome or Wolff-Parkinson-White syndrome

    • Allergic reactions to lidocaine

    • Liver disease or kidney disease

    • Heart disease or coronary artery disease

    • Malignant hyperthermia

  • What happens if I miss a dose of lidocaine?

    If you miss a dose of lidocaine, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much lidocaine?

    If you've taken too much lidocaine, seek emergency medical help or contact your local poison control center.

  • Can I buy lidocaine over the counter?

    Many local pharmacies carry weaker strength lidocaine products in topical forms such as creams, gels and patches. Higher strength options require a prescription. A doctor's oversight ensures you get the right lidocaine concentration for your specific pain. Our telemedicine appointments are available with or without insurance, and we accept most major plans.

    Seeing a doctor online goes beyond just a prescription. We can identify the underlying cause of your pain, which might require additional treatment. We can also discuss potential side effects of lidocaine specific to you and ensure it doesn't interact with any other medications or supplements you're taking. With a complete picture of your health history, our doctors can recommend the safest and most effective pain management plan for you.

3 simple steps to request your lidocaine prescription today 

Step 1

Book a lidocaine prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Lidocaine prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your lidocaine prescription.

We can send prescriptions to any local pharmacy.

Lidocaine prescription pricing details

How pricing works

To get a new or refill on your lidocaine prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


PlushCare is dedicated to providing you with accurate and trustworthy health information.

PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.