Trintellix medication - online prescription available for major depressive disorder (MDD)

If you are suffering from major depressive disorder, Trintellix can help. Get a same-day prescription or refill of Trintellix from a caring, board-certified doctor online.*

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FDA-approved for mood disorders

Manage your mental health with Trintellix

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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Trintellix medication

Trintellix is considered a combination antidepressant. It combines both a serotonin (5-HT) receptor modulator and an SSRI in one drug, which functions by reducing the uptake of serotonin in the brain. Like any SSRI prescription medicine, this medication can only be used for long-term treatment of major depressive disorder. It is ineffective against acute anxiety attacks or panic disorder because it will not provide an immediate relief of these symptoms.

Some conditions that Trintellix is known to treat include major depressive disorder. Trintellix is available only by prescription. It is available in a generic formulation as well as under different brand names, including vortioxetine.

Trintellix was initially known as Brintellix, but the name was changed in June 2016. This came after confusion with Brintellix and another type of drug known as Brilinta, which is used in anti-blood clotting therapy.  

Trintellix may be prescribed as a capsule. There are three different strengths of tablets or capsules that can be used to treat major depressive disorder:

  • 5 mg

  • 10 mg

  • 20 mg

It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage that you are prescribed.

If you are prescribed Trintellix, be sure to complete the full course of the antidepressant medication unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the antidepressant medication may not fully treat your major depressive disorder. If you suddenly stop Trintellix, then you may experience withdrawal symptoms. These withdrawal symptoms can sometimes be severe. They can also lead to worse symptoms than before you started the medication. Only consider stopping treatment if healthcare professionals advise you to.

Trintellix uses

There is only one official FDA-approved use for Trintellix, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Major depressive disorder (MDD)

    The use of Trintellix tablets has been approved for use in patients with major depressive disorder (MDD). It is not, however, advised for patients who also have signs of bipolar disorder or those who have a history of serotonin syndrome. Patients with major depressive disorder (MDD) may experience a consistently low mood, as well as a sense of despair. Consistent sadness is another common sign of this depression type. A healthcare professional will closely monitor the patient when they use Trintellix. This can help to ensure worsening symptoms are identified early on. There are also strict regulations regarding the use of Trintellix along with other drugs, such as tricyclic antidepressants, monoamine oxidase inhibitors, and certain types of over-the-counter medicines.

Trintellix side effects

  • The side effects associated with taking Trintellix are typically mild to moderate. They may include:

    • Constipation

    • Vomiting

    • Nausea

    Other side effects, which are less common but might be more severe, could include:

    • Serotonin syndrome: In some rare cases, patients who use these prescription drugs develop a condition known as serotonin syndrome. This is why avoiding other drugs that also affect serotonin levels, or certain brain chemicals is crucial when using Trintellix. Difficulty concentrating, agitation, fast heart rate, sweating, hallucinations, and severe digestive system symptoms may occur when the patient develops serotonin syndrome. The condition may also lead to new or worsening symptoms. Patients may need to contact a poison control center or an emergency medical department if they experience signs of serotonin syndrome.

    • Low sodium: Older adults treated with Trintellix have a risk of developing low sodium levels. This can cause a number of adverse effects, including memory problems, confusion, slurred speech, and weakness. A healthcare professional should be advised if you generally struggle to keep your sodium levels balanced.

    • Allergic reaction: Just as with many other drugs on the market, there is a small risk of developing allergic reactions when taking Trintellix.

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Use of Trintellix in young children under age 18 is not advised because it can cause an increased risk of certain side-effects, such as serotonin syndrome. The patient may also experience new or worsening symptoms of their depression if they use the medication at a young age.

How to take Trintellix

Your pharmacist will provide you with instructions on how to take your Trintellix prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Trintellix can come in different forms and doses, so be sure to follow the specific instructions on your prescription. It is typically prescribed once per day. Some specific instructions may include taking Trintellix with or without food.

Do not take more of the medication than what healthcare professionals prescribe to you. These prescription drugs can cause serotonin syndrome if you take too much.

What to avoid while taking Trintellix medication

Trintellix has numerous potential drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

It is important to avoid using tricyclic antidepressants or any other type of antidepressant medication when taking Trintellix.

Apart from other antidepressant medicine options, you should also tell your doctor if you use any of the following medications:

  • Buspirone

  • Lithium

  • Fentanyl

  • Tramadol

  • St. John's wort supplements

  • Blood thinners

  • Diuretics

  • Triptans

It is also not advisable to use Trintellix with nonsteroidal anti-inflammatory drugs. Combining nonsteroidal anti-inflammatory drugs may increase the risk of bleeding problems and other side effects.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Trintellix.

Some research shows that regular alcohol consumption has a depressive effect on the central nervous system. Alcohol may also reduce the medication’s ability to do its job, making it harder to treat depression.

Medication alternatives to Trintellix

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another SSRI and serotonin (5-HT) receptor modulator combination or an antidepressant in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Generalized anxiety disorder

    Patients with a generalized anxiety disorder may experience panic attacks and are generally anxious throughout the day. In these cases, specific prescription medicine may help treat the condition.

    • Benzodiazepines



    Klonopin (clonazepam)

Trintellix prescription FAQs

  • How much does Trintellix cost?

    There are several variables you need to consider when you ask about Trintellix cost. There are multiple dosage options available. This will have an impact on the price. You may start off with a small initial dose, then the healthcare provider may increase the dose later on.

  • How can I refill my Trintellix prescription?

    Trintellix is a long-term treatment for depression. This means you will need to hand your prescription in at a local pharmacy and visit them every month to obtain a refill for your prescription medicine.

  • Can you feel Trintellix immediately?

    Even though this medication comes in the form of a fast-release tablet, you will not experience the effects immediately. It is not an acute treatment option. Even though it starts to work on certain natural substances early on, it may take up to eight weeks before you start to notice the full effects of the medication.

  • What medications should not be taken with Trintellix?

    List all the drugs you take for your doctor and tell them about a family history of suicidal thoughts or attempts, bipolar disorder, and other mental health concerns. Do not mix Trintellix with other drugs that are also used to treat depression. You should also be careful about taking Trintellix with blood thinners, blood pressure medication, and several other drugs. These medications can produce drug interactions.

  • How long does it take to get used to Trintellix?

    Some people may experience side effects like nausea and headaches during the early stages of treatment. If you have worsening symptoms, tell your doctor. The majority of side effects should subside after a few weeks of use.

  • How do you feel after taking Trintellix?

    You will likely not feel any immediate effects. Over a period of six to eight weeks, you may experience an improved mood and fewer mood swings. You may also find that you do not feel so sad all the time.

  • Who should not take Trintellix?

    It is generally not advised to take Trintellix if you have bipolar disorder or require treatment for generalized anxiety disorder. Do not take the medication if you have a personal or family history of suicidal thoughts or attempts.

  • What happens if I miss a dose of Trintellix?

    A missed dose of Trintellix can reduce the efficacy of the medication. Take the dose once you remember. With this said, the missed dose should not be taken too close to your next dose.

  • What happens if I take too much Trintellix?

    You always have to adhere to the instructions that your healthcare provider offers strictly. If you take too much, you may experience more severe difficulty concentrating, nausea, and other side effects. Tell your doctor if you think you took too much and if you experience worsening depression. You might need to go to an emergency department if you took a significant amount of the medication.

3 simple steps to request your Trintellix medication prescription online

Step 1: Book an appointment

Step 1

Book a Trintellix prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Trintellix prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Trintellix prescription.

We can send prescriptions to any local pharmacy.

Trintellix prescription pricing details

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First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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