The most reported side effects from Sotyktu® (deucravacitinib) include, but are not limited to1, 2
- Cold sores in or around the mouth
- Acne
- Folliculitis
- Common cold symptoms and upper respiratory infections
Our doctors are here to help you with plaque psoriasis and navigating if Sotyktu® (deucravacitinib) is right for you.
Sotyktu® (deucravacitinib) is an FDA-approved prescription medication intended to alleviate symptoms of plaque psoriasis.1, 2 It is a selective allosteric tyrosine kinase 2 (TYK2) inhibitor taken in the form of a once-daily 6mg oral tablet.1, 2
Our doctors can discuss different treatments for psoriasis, referrals, and if Sotyktu® is right for you. Contact our top-rated doctors today and discover the best treatment plan for managing your symptoms.
Sotyktu® is primarily used to treat moderate to severe plaque psoriasis in adults. When a person has plaque psoriasis, their immune system attacks healthy skin cells, which causes the skin to become inflamed and the body to create too many skin cells.3 When this occurs, patches of itchy, thickened, discolored skin—known as plaques—can form all over the body.3 Plaque psoriasis flare-ups are often brought about by a variety of triggers including sunburn, dry skin, smoking, alcohol consumption, stress, and skin injuries.3
While topical creams and light therapy are often sufficient treatments for plaque psoriasis, some people may require medications to manage symptoms.3 Sotyktu® is FDA-approved and proven to be effective in treating plaque psoriasis compared to placebo and competitors.2
Most side effects associated with taking Sotyktu® are mild; in two clinical trials, only 2.4% of patients prescribed Sotyktu® had to stop taking the medication because of adverse reactions.2
If you are taking Sotyktu® (deucravacitinib) and experience any uncomfortable or side effects, you should contact your doctor as soon as possible. In case of an allergic reaction or emergency, dial 911.
The most reported side effects from Sotyktu® (deucravacitinib) include, but are not limited to1, 2
In some cases, Sotyktu® (deucravacitinib) can cause more serious side effects, such as:1, 2
If you experience any of these severe side effects, you should call 911 or go to the emergency room immediately.
Sotyktu® is intended for long-term use in adults with moderate to severe plaque psoriasis.1, 2, 6 Side effects tend to be manageable and mild, and only 2.4% of patients prescribed Sotyktu® during clinical trials had to cease taking it because of adverse reactions.2
People taking Sotyktu® may see a reduction in plaque psoriasis symptoms immediately after beginning the medication.6 In clinical trials, participants saw a significant reduction in symptoms by week 16.2, 6
Before starting Sotyktu®, you should talk to your medical practitioner about any prescription or over-the-counter medications and supplements you are taking. Sotyktu® should not be taken in conjunction with other potent immunosuppressants meant to treat plaque psoriasis or any other condition.2
Sotyktu® is a prescription pill that is typically taken orally once per day with or without food.1 It comes as a 6mg tablet.2
At this time, it is unknown whether or not drinking alcohol can interfere with Sotyktu® or cause adverse side effects.4 Talk to your doctor about your drinking habits before taking Sotyktu®.
There is currently no cure for psoriasis.3 However, Sotyktu® can help manage the symptoms of moderate to severe plaque psoriasis when topical creams and light therapy have been ineffective.1, 2
If you forget to take a dose of Sotyktu®, you should take it as soon as you remember—with an important exception being if you are close to your next dose.4 In this case, simply skip the missed dose and take the next one (in other words, do not take two doses at once).4
Sotyktu® can ameliorate the symptoms of moderate to severe plaque psoriasis when topical creams and light therapy have had little effect.1, 2 When compared to Otezla® (apremilast), Sotyktu® led to greater improvement from baseline symptoms in clinical trial participants.2
Before starting Sotyktu®, you should talk to your medical practitioner about any prescription or over-the-counter medications and supplements you are taking, including topical creams, to ensure there is no risk of interaction. Sotyktu® should not be taken in conjunction with other potent immunosuppressants meant to treat plaque psoriasis or any other condition.2
It is unknown at this time if Sotyktu® is safe for people who are pregnant or breastfeeding.4. If you are pregnant, breastfeeding, or planning to become pregnant, be sure to discuss the safety of Sotyktu® with your doctor.
Sotyktu® may be covered by insurance depending on your plan, where you live, what pharmacy you use, and what dosage you require.7 You may be required to obtain prior authorization before your insurance approves Sotyktu®.7 Sotyktu® also offers a Co-pay Assistance Program that may provide financial support to offset costs.8
Sotyktu® is a selective allosteric tyrosine kinase 2 (TYK2) inhibitor that works to slow the overactivity of the immune system to reduce inflammation and associated plaque psoriasis symptoms.1, 2, 3 As such, you may be more prone to serious infections while taking Sotyktu®.2, 4 If you have a history of infections, including tuberculosis, be sure to discuss this with your doctor.4
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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.