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- Women’s Health
Premarin
Premarin online estrogen prescription available
Premarin vaginal cream relieves vaginal discomfort, dryness, and itching; painful sex, and urinary tract symptoms after menopause. Consult with our doctors today and get a new prescription or refill of Premarin today.
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Relief from vaginal and urinary symptoms of menopause
Virtual care for vaginal health
Request Premarin in as little as 15 minutes, with or without insurance*
*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.
Learn about Premarin vaginal cream
Premarin vaginal cream is considered a conjugated estrogen cream, which contains a mixture of estrogen hormones. Conjugated estrogens help treat changes in and around the vagina, such as dryness, itching, and burning in postmenopausal women. It can also help treat vaginal pain during sexual intercourse.
Premarin vaginal cream is available only by prescription. There are several other topical estrogen creams and products, like Estrace or estradiol, that can also improve genitourinary symptoms of menopause. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.
Premarin vaginal cream uses
Premarin vaginal cream is used to relieve genitourinary symptoms of menopause, including vaginal dryness, pain with intercourse, and recurrent urinary tract infections (UTIs).
Treatment of vaginal dryness: Menopause causes a decrease in estrogen levels, which can result in vaginal dryness. Premarin vaginal cream can help to restore the natural moisture and elasticity of the vaginal tissues, reducing discomfort and pain during sexual and other daily activities.
Treatment of vaginal atrophy: As estrogen levels decline during menopause, the tissues of the vagina may become thin and more fragile. This can lead to vaginal atrophy, which can cause pain during sexual activity, urinary incontinence, and urinary tract infections. Premarin vaginal cream can help to restore vaginal tissues and reduce these symptoms
Premarin cream is also sometimes used in younger women and children with specific vulvar issues including labial adhesions.
Other forms of estrogen, but not topical estrogens, are sometimes used to help prevent osteoporosis.
Talking to your doctor about the risks and benefits of using Premarin or another estrogen-based vaginal cream is important, as it may not be appropriate for everyone. Your doctor can help you determine if this medication is right for you and provide guidance on how to use it safely and effectively.
Premarin vaginal cream side effects
Premarin vaginal cream has some common side effects, which are typically mild. They may include:
Breast changes, such as breast pain or tenderness
Vaginal discharge
Nausea or abdominal discomfort
Headache
Other side effects, which are less common but might be more severe, could include:Unusual vaginal bleeding after menopause
Moderate to severe hot flashes
Dizziness
You should call your healthcare provider if you notice any of these side effects or if you develop any other new or concerning symptoms. Report any unusual vaginal bleeding right away.
Using estrogen may increase your risk of several health problems, including heart attack, stroke, blood clots, breast cancer, and endometrial cancer. Topical estrogens have much less systemic absorption than oral estrogens, thus the risk of severe complications is much lower. Still, because of these risks, your healthcare provider will prescribe estrogen at the lowest effective dose to relieve your symptoms.
How to use Premarin vaginal cream
Your doctor and pharmacist will provide you with instructions on how to use your Premarin or vaginal estrogen cream. Be sure to read your prescription label and follow the instructions. Call your healthcare provider or pharmacy if you have any questions. The following general guidelines can help you understand how to use this medication:
Wash your hands thoroughly with soap and water before using the cream.
Remove the cap from the tube of Premarin vaginal cream.
Attach the applicator to the open end of the tube.
Squeeze the tube to fill the applicator with the prescribed amount of cream. Your healthcare provider will give you specific instructions on how much and how often to use it.
Lie on your back with your knees bent, or stand with one foot on a chair or other elevated surface.
Gently insert the applicator into the vagina as far as it will comfortably go.
Press the plunger of the applicator to release the cream.
Remove the applicator and dispose of it in the trash.
Wash your hands thoroughly with soap and water after using the cream.
Store the tube of Premarin vaginal cream at room temperature, away from heat and light.
It is important to follow your healthcare provider's instructions for using Premarin vaginal cream and to use it only as prescribed. Contact your healthcare provider immediately if you experience any unusual symptoms or side effects while using this medication.
What to avoid while using Premarin vaginal cream
Premarin can interact with other medications, supplements, and over-the-counter drugs. There are some things you should avoid while using Premarin vaginal cream:
Do not use other vaginal products at the same time as Premarin vaginal cream unless your healthcare provider has specifically instructed you to do so. Using other vaginal products (such as douches, spermicides, or other creams) at the same time as Premarin or other vaginal estrogen creams may interfere with their effectiveness.
Avoid sexual activity immediately after using Premarin vaginal cream. The cream may weaken latex condoms and diaphragms, making them less effective.
Avoid using Premarin vaginal cream if you have a history of certain medical conditions, such as breast cancer or a history of blood clots. Talk to your healthcare provider about your medical history before using this medication.
Avoid using Premarin vaginal cream during pregnancy or while breastfeeding unless your healthcare provider has specifically instructed you to do so.
Avoid getting Premarin vaginal cream in your eyes, nose, or mouth. If this occurs, rinse the affected area thoroughly with water.
Avoid storing Premarin vaginal cream in temperatures above 86°F (30°C), as this may cause the medication to break down and become less effective.
It is important to follow your healthcare provider's instructions for using Premarin vaginal cream and to talk to them about any questions or concerns you may have about the medication.
Medication alternatives to Premarin vaginal cream
There are several medication alternatives to Premarin vaginal cream for treating vaginal dryness, itching, and burning associated with menopause.
Vaginal estrogen creams
Like Premarin vaginal cream, other vaginal creams containing estrogens, such as Estrace, Estring, and Vagifem, are applied directly to the vagina and work to restore vaginal moisture and elasticity. They are created using different compounds than Premarin but function similarly.
Vaginal moisturizers
Unlike vaginal estrogen creams, vaginal moisturizers do not contain estrogen. Instead, they are water-based products designed to provide long-lasting moisture to the vaginal tissues. Examples include Replens, Luvena, and KY Liquibeads. Many people use daily vaginal moisturizers along with topical estrogen therapy.
Systemic hormone therapy
Instead of vaginal estrogen therapy, some women may benefit from systemic estrogen therapy, such as a pill or patch. In addition, other hormones such as selective estrogen receptor modulators (SERMs) may be prescribed for both systemic and genitourinary symptoms of menopause. However, systemic hormone therapy is not recommended for all women, as it may increase the risk of specific health problems, such as blood clots, stroke, and possibly breast cancer.
Non-hormonal treatments
Several non-hormonal treatments may also be effective for treating vaginal symptoms, such as vaginal lubricants, pelvic floor PT, and vaginal dilators.
It is essential to talk to your healthcare provider about the risks and benefits of these medication alternatives and any other treatment options that may be appropriate for your needs. They can help you determine the best course of treatment based on your medical history, symptoms, and preferences.
Premarin online prescription FAQs
When is the best time to use Premarin vaginal cream?
It's best to use Premarin vaginal cream before bed. Since you'll be laying down after the application, you won't have to worry about excess leakage.
How long does Premarin vaginal cream take to work?
Premarin vaginal cream can provide relief in as little as four weeks. However, it may take up to 12 weeks to see the full effect of your Premarin prescription.
How many doses are in 14 g of Premarin vaginal cream?
Although dosage will vary depending on your symptoms, approximately 28 doses are in 14 g of Premarin vaginal cream. The initial starting dose for Premarin is 0.5 g/day.
What is a generic drug for Premarin vaginal cream?
There is no generic drug for Premarin. However, there are alternative vaginal estrogen creams, such as Estrace, that come in generic formulas called estradiol.
Generic vaginal estrogens often come with a lower out-of-pocket cost than the brand-name prescription drug. Pharmacy benefit programs can also help you get maximum savings on your prescription costs.
What happens if I take too much Premarin vaginal cream?
If you've taken too much Premarin, call your healthcare provider. While adverse effects are rare, some women may notice nausea, breast pain, fatigue, or withdrawal bleeding (bleeding after menopause).
Can I buy vaginal estrogen cream over the counter?
While some over-the-counter (OTC) moisturizers can offer temporary relief for vaginal pain or dryness associated with menopause, they can't replace the effectiveness of prescription vaginal estrogen cream. It's important to talk with a qualified doctor to get effective medical treatment.
Your doctor can pinpoint the underlying cause of your vaginal dryness and determine if vaginal estrogen cream is the best treatment for you. Your doctor will also take your full health history and prescribe the right dose for treatment to minimize risks and maximize benefits. Your doctor can adjust the dosage or medication as needed.
Our board-certified primary care physicians are available 24/7 for convenient online consultations. Within an hour, you can discuss your symptoms, receive a diagnosis, and get an online prescription for vaginal estrogen cream (if it's the right treatment for you).
3 simple steps to request your Premarin estrogen prescription online
Step 1
Book a Premarin vaginal cream prescription request appointment.
Book a same day appointment from anywhere.
Step 2
Talk to your medical provider regarding your Premarin estrogen cream prescription.
Visit with a doctor on your smartphone or computer.
Step 3
Pick up your Premarin cream prescription.
We can send Premarin prescriptions online to any local pharmacy.
Premarin vaginal cream prescription pricing details
How pricing works
To get a new or refill on your Premarin vaginal cream prescription, join our monthly membership and get discounted visits.
Paying with insurance
Membership
$16.99/month
First month free
Visits
Copay
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price with insurance
Often the same as an office visit. Most patients with in-network insurance pay $30 or less!
- We accept these insurance plans and many more:
Paying without insurance
Membership
$16.99/month
First month free
Visits
$129
30 days of free membership
Same-day appointments 7 days a week
Unlimited messages with your Care Team
Prescription discount card to save up to 80%
Exclusive discounts on lab tests
Free memberships for your family
Cancel anytime
Visit price without insurance
Initial visits are $129.
If we're unable to treat you, we'll provide a full refund.
Premarin Vaginal cream prescription resources
Sources:
PlushCare is dedicated to providing you with accurate and trustworthy health information.
Food and Drug Administration. Premarin prescription label. Accessed on September 16, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020216s059lbl.pdf
Mayo Clinic. Conjugated estrogens (vaginal route). Accessed on September 26, 2022. https://www.mayoclinic.org/drugs-supplements/conjugated-estrogens-vaginal-route/side-effects/drg-20075461?p=1
Medscape. Premarin vaginal cream (conjugated estrogens, vaginal). Accessed on September 16, 2022. https://reference.medscape.com/drug/premarin-vaginal-cream-conjugated-estrogens-vaginal-999949#5
PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.