Nexium (Esomeprazole) Prescriptions Available Online Today

Our doctors are here to help. Nexium can treat heartburn, ulcers, gastroesophageal reflux disease, Zollinger-Ellison syndrome, and more. Speak to one of our board-certified doctors to see if Nexium is right for you.

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An doctor at PlushCare can help you request a prescription online from your phone.

Can You Get Nexium (Esomeprazole) Online?

Yes, licensed medical doctors can prescribe Nexium (Esomeprazole) online after a medical evaluation.

You can speak with one of our online doctors to learn more about Nexium. Book an online appointment with one of our top doctors using your phone or computer.

During your virtual visit, a physician will review your symptoms and medical history to provide a diagnosis. If the doctor determines that a patient would qualify for Nexium, they can write a prescription and electronically send it to a nearby pharmacy for pickup.

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What Is Nexium (Esomeprazole)?

Nexium comes as a delayed release capsule (enteric coated). It is a proton pump inhibitor, which lessens the production of stomach acid, allowing acid reflux to subside. Nexium stays in your bloodstream for an extended period, helping to quell the symptoms of acid reflux. Relief is not immediate but sustained use will help a range of conditions over the course of a couple weeks.

Nexium is not a medication that you should take consistently as chronic liver disease can result from suppressing acid with a pump inhibitor drug. Most mild to severe stomach acid problems are resolved within a few sessions of use but persistent problems can indicate a serious condition like gastritis.

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Nexium FAQs

How Does Nexium Work?

Proton pump inhibitors like Nexium are the primary form of treatment for gastroesophageal reflux. This condition occurs due to excess stomach acid.

Nexium inhibits the secretion of gastric acid by inhibiting the potassium pump upon the membrane of the gastric parietal cell. Unlike other acid reflux medications, proton pump inhibitors do not slow your digestion. Nexium is often used to treat the following conditions:

  • Dyspepsia
  • Peptic Ulcers
  • Gastroesophageal Reflux Disease
  • Zollinger-Ellison Syndrome (Pancreatic Tumors)

Nexium is also an extremely useful medication for those who are being treated with nonsteroidal anti-inflammatory drugs (NSAIDS). Long-term use of NSAIDs increases the risk of stomach ulcers but taking Nexium prevents this.

What Are the Associated Dosages and Treatments for Nexium?

Nexium is usually taken as a delayed-release capsule or oral suspension, both formulations are taken at least one hour before a meal. Oral suspensions are taken by mixing the contents of a packet into a glass of water. Let the mixture sit for a few minutes to thicken and drink within 30 minutes. For any residual powder left on the bottom of the glass, add more water and drink immediately.

For treatment of GERD, a 20 or 40 mg capsule is taken once/day over the course of 4 to 8 weeks. Dosages are reduced for children 11 years old or younger.

For pathological hypersecretory conditions like Zollinger-Ellison syndrome, 40 mg capsules are taken twice a day.

Nexium I.V. is injectable esomeprazole sodium. This formulation is sometimes used for GERD with erosive esophagitis or rebleeding of gastric or duodenal ulcers after therapeutic endoscopy.

What Are the Considerations and Precautions for taking Nexium?

If your acid reflux does not subside within two weeks then contact a doctor. Nexium should not be taken for more than 2 consecutive weeks within a four-month period. The more you use Nexium, the higher the risk of side effects.

All medications classed as proton pump inhibitors can have adverse reactions in patients suffering from kidney disease. Nexium should also not be taken by anyone with severe liver disease. Those who have low magnesium levels, Lupus, or any bone density issues should first contact a doctor before using Nexium.

Continual gastric reflux problems can show serious underlying issues.

You should tell your doctor before using Nexium if you’ve ever had:

  • Low magnesium levels
  • Lupus
  • Osteoporosis or low bone mineral density (osteopenia)
  • Severe liver disease

Nexium can also interact with many medications. Tell your doctor about any medications you take, especially:

  • Antifungal medication like ketoconazole or voriconazole
  • Cilostazol
  • Clopidogrel
  • Diazepam
  • Digoxin
  • HIV/AIDS medication like atazanavir, nelfinavir, or saquinavir
  • Iron-containing medicines (ferrous fumarate, ferrous gluconate, ferrous sulfate, and others)
  • Methotrexate
  • Mycophenolate mofetil
  • Rifampin
  • St. John’s wort
  • Tacrolimus
  • Warfarin (Coumadin, Jantoven)

What Are the Benefits of Nexium?

Nexium is highly beneficial in the treatment of gastroesophageal reflux

Nexium reduces symptoms of too much stomach acid. In most cases, Nexium is prescribed for short-term use, usually four to eight weeks. This provides enough time for a patient to heal from acid damage. Occasionally that time frame is extended to give people additional healing time.

Nexium can also be used long-term for Maintenance of erosive esophagitis or pathological hypersecretory conditions such as Zollinger-Ellison syndrome.

Many drugs require dosage adjustments for people with kidney disease, Nexium does not.

Does Nexium Have Side Effects?

Most common side effects of Nexium (affects over 10% of patients):

Common side effects of Nexium (affects 1 to 10% patients):

  • Changes in taste or unpleasant aftertaste
  • Dizziness or vertigo
  • Abdominal pain, constipation, diarrhea, nausea, or vomiting
  • Coughing, respiratory infection, or sinusitis
  • High blood pressure
  • Pruritus
  • Back pain
  • Viral infection
  • Increased alanine aminotransferase (ALT)

Reasons to call a doctor right away:

  • Severe stomach pain or bloody diarrhea
  • Seizures
  • Urination problems (blood in urine, reduced urine)
  • Fast or irregular heart rate
  • Tremors, muscle spasms, muscle cramps, or feeling jittery
  • Joint pain
  • Rash on arms or cheeks that worsens in sunlight
  • Choking sensation

Get emergency medical attention if you have a severe allergic reaction to Nexium, which causes hives; difficulty breathing; and swelling of the face, lips, throat, or tongue.

Is Nexium Safe For Long-Term Use?

Physicians commonly prescribe Nexium for long-term usage. Always be sure to speak with a doctor to discuss any benefits, risks, and side effects of this prescription, especially when using it long-term.

When patients take Nexium longer than three months, they may experience lower magnesium levels in their blood, especially if they take diuretics or digoxin.

These are some common symptoms of lower magnesium levels:

  • Dizziness
  • Disorientation
  • Muscle spasms
  • Abnormal heartbeat

Should a patient experience these symptoms, the doctor may want to test their magnesium levels. The physician may also put them on a magnesium supplement and discontinue their use of Nexium.

PPIs have also been associated with slight increases in bone fractures in the wrist, spine, and hip when taken in higher doses for more than a year. Using a PPI on a long-term basis can reduce the amount of vitamin D and calcium the digestive system absorbs. 

There is also a higher risk for bone fractures if the patient:

  • Is older
  • Has osteoporosis

Your doctor may advise that you take vitamin D and calcium supplements while taking Nexium if you have those risk factors. 

Your doctor may also advise taking vitamin B12 supplements if you are taking Nexium for three years or longer. The purpose of taking the vitamin supplement is due to the body not absorbing enough vitamin B12 from the diet. 

A patient is at a higher risk of a vitamin B12 deficiency if they are:

  • Older
  • Vegetarian
  • Have undergone weight loss surgery

Vitamin B12 deficiency may cause feelings of pins and needles or a tingling sensation in your  extremities, weakness, anemia, and jaundice. Should a patient have a vitamin B12 deficiency and take Nexium, the doctor may want to treat them with vitamin B12 tablets or shots in high dosage.

Read: Acid Reflux Medicine

Are There Any Drug Interactions When Taking Nexium?

It is essential to meet and consult with a doctor about potential drug interactions before taking Nexium. It is also vital to let the doctor know about any other medications you may be taking before using Nexium. That includes any prescription drugs, vitamins, or herbal supplements. 

Nexium can interact with and affect how other medications work. Be sure to let your doctor know if any of the following medications are currently prescribed and used:

  • Rifampin
  • Warfarin
  • St. John’s Wort
  • Diazepam
  • Methotrexate
  • Products Or Supplements With Iron
  • Clopidogrel (Plavix)
  • Voriconazole (Vfend)
  • Digoxin (Lanoxin)
  • Mycophenolate Mofetil (Cellcept)
  • Cilostazol
  • Saquinavir
  • Tacrolimus

Where Can You Buy Nexium Online?

Yes, Nexium is available online.

If want to discuss with a doctor if Nexium is right for you or get a prescription for 40mg Nexium you can now do so online with a PlushCare doctor.

Book an appointment today with PlushCare and get diagnosed and prescribed the best treatment for your condition.


Telehealth is not appropriate for serious conditions that require immediate attention or emergency care. If you experience any life-threatening issues, call 911 or go to an emergency room immediately.


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