Lidex (fluocinonide) prescription available online

If you are suffering from itching and inflammation, Lidex (fluocinonide) can help. Get a new prescription or refill of Lidex from a board-certified doctor online.*

Book an appointment

Ease itching and inflammation

Available as a topical solution, cream, gel, or ointment

FDA-approved to treat plaque psoriasis, eczema, and allergic reactions

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Lidex (fluocinonide)

Fluocinonide belongs to a class of drugs called corticosteroid medications, which prevent the release of substances in the body that cause inflammation.

Fluocinonide topical solution is used to treat inflammation and itching caused by plaque psoriasis, eczema, dermatitis, and other inflammatory skin conditions. Fluocinonide is available only by prescription. It is available in a generic formulation as well as under different brand names, including Lidex.

Fluocinonide may be prescribed as a topical solution, cream, gel, or ointment. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed fluocinonide, be sure to complete the full course of the corticosteroid unless your health care professional specifically tells you to stop. If you don’t complete your prescription, the corticosteroid may not fully treat your skin condition.

Lidex uses

There are several FDA-approved uses for fluocinonide, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your health care professional may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Inflammatory skin conditions

    Fluocinonide topical solution is FDA-approved to treat skin conditions that respond to corticosteroid medications, including plaque psoriasis, eczema (atopic dermatitis), and allergic reactions.

Lidex (fluocinonide) side effects

  • The side effects associated with taking fluocinonide are typically mild. Most fluocinonide side effects are associated with skin reactions. Common side effects may include:

    • Burning, stinging, itching, or discomfort of treated skin

    • Redness or crusting around your hair follicles

    • Lightened color of the affected area

    Other side effects, which are less common but might be more severe, could include:

    • Redness, warmth, or severe irritation of treated skin

    • Worsening of your skin condition

    • Signs of a skin infection

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. The use of Lidex topical solution is not recommended in young children under 12, as children may absorb higher amounts of fluocinonide than adults.

How to take Lidex (fluocinonide)

Your pharmacist will provide you with instructions on how to take your fluocinonide prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Fluocinonide can come in different forms and doses, so be sure to follow the specific instructions on your prescription. Apply a thin layer of topical solution over the affected area and rub it in gently. Avoid applying Lidex over a large area of skin unless your doctor tells you otherwise.

Avoid covering treated skin with a bandage or other covering, as this can increase the amount of medicine absorbed into your skin. Your doctor may recommend regular medical and lab appointments, as well as adrenal gland function tests, to make sure corticosteroids are safe for you.

What to avoid while taking Lidex

Fluocinonide has 45 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with fluocinonide include:

  • Benadryl (diphenhydramine)

  • Low-strength aspirin

  • Vitamin B12, C, and D3

  • ProAir HFA (albuterol)

  • Zyrtec (cetirizine)

Ask your doctor for medical advice before drinking alcohol. Although alcohol doesn't directly interact with Lidex, it can potentially worsen underlying skin conditions.

Medication alternatives to Lidex

If your healthcare provider prefers to put you on another treatment altogether, they may suggest topical corticosteroids or other corticosteroids in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Lidex prescription FAQs

  • How much does fluocinonide cost?

    Depending on your pharmacy, fluocinonide costs around $17 for 30 grams without insurance. Fluocinonide is a generic brand, and brand names may cost more.

  • How can I refill my fluocinonide prescription?

    Lidex (fluocinonide) is only available by prescription, so you will need to see a board-certified doctor to get a refill on your prescription. To get started, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • What happens if you use too much fluocinonide?

    Using too much corticosteroid medicine can increase your risk of adrenal gland problems. Chronic topical corticosteroid therapy can also lead to thinning skin, easy bruising, and changes in body fat.

  • Where should you not use fluocinonide?

    Avoid using Lidex on large areas of skin unless directed by your doctor. Avoid using Lidex on the face, groin, or underarms.

  • How long does it take fluocinonide to start working?

    Fluocinonide should start improving your symptoms within two weeks of starting treatment. Tell your doctor if your symptoms don't improve within two weeks.

  • Who should not take fluocinonide?

    To make sure fluocinonide is safe for you, tell your doctor if you have:

    • Any type of skin infection

    • A skin reaction to any steroid medicine

    • An adrenal gland disorder

    • Diabetes

  • What happens if I miss a dose of fluocinonide?

    If you miss a dose of fluocinonide, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much fluocinonide?

    If you've taken too much fluocinonide or accidentally swallowed the topical solution, seek emergency treatment, or contact your local poison control center or provincial poison control center (for Canada residents).

3 simple steps to request your Lidex prescription today

Step 1

Book a Lidex prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Lidex prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Lidex prescription.

We can send prescriptions to any local pharmacy.

Lidex (fluocinonide) prescription pricing details

How pricing works

To get a new or refill on your fluocinonide prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Lidex prescription resources


PlushCare is dedicated to providing you with accurate and trustworthy health information

PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.