Entresto (sacubitril/valsartan) prescription available online 

If you are suffering from heart failure, Entresto can help. Get a new prescription or refill of Entresto from a board-certified doctor online.*

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FDA-approved for chronic heart failure therapy

Available in capsule or liquid form

Save up to 74.95% on Entresto* with RX discount card

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Entresto (sacubitril valsartan)

Entresto is a combination drug that uses two medications to treat conditions like chronic heart failure. The drug belongs to two classes neprilysin inhibitors and angiotensin receptor blockers. Like any heart failure medication, this medication can only be used for existing conditions of cardiovascular diseases, including chronic heart failure. It is ineffective against heart attacks, strokes, and similar cardiovascular events because it will not provide an immediate effect in these scenarios.

Some conditions that Entresto is known to treat include chronic heart failure. Entresto is available only by prescription. It is available in a generic formulation under different brand names, including sacubitril and valsartan.

Entresto may be prescribed as a capsule or oral suspension. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Entresto, be sure to understand that you will likely need to use the medication to treat heart failure over a long period of time. The medication can help to reduce the risk factors associated with severe cardiovascular death and other events. The treated patients should only stop using the medicine if healthcare professionals advise them. This can cause symptoms of chronic heart failure to reemerge.

Entresto (sacubitril valsartan) uses

There is one FDA-approved use for Entresto, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for the following reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Chronic heart failure

    The FDA has approved the use of Entresto as chronic heart failure therapy. The medicine works by combining two drugs in order to reduce the symptoms that the patient experiences. The main goal of this combination is to reduce the risk of hospitalization and cardiovascular death among patients who have chronic heart failure. The angiotensin II receptor antagonists in this medication block the actions of certain chemicals in the body. The angiotensin II receptor blocker is combined with neprilysin inhibitors to further improve symptoms when used to treat heart failure.

Entresto (sacubitril valsartan) side effects

The side effects associated with taking Entresto are typically moderate to severe. Most Entresto side effects are associated with the kidneys.

  • Entresto has some common side effects. They may include:

    • An increase in potassium levels

    • A light-headed feeling

    • Coughing

    • Dizziness

    It is also important to note that Entresto can affect kidneys. This can lead to acute renal failure in serious cases. Patients should ensure they understand the potential symptoms of acute renal failure and compromised renal function. This can ensure the individual recognizes acute renal failure and can obtain appropriate treatment in a timely manner.

    Other side effects, which are less common but might be more severe, could include:

    • High potassium: If the patient has a high potassium diet and they use Entresto, they may experience an excessive accumulation of potassium in their body. This can also happen when Entresto is combined with potassium supplements. High potassium levels can lead to a slower heart rate, muscle weakness, and a weak pulse. In some cases, this can lead to medical emergencies.

    • Pregnancy and breastfeeding: Patients treated who find out they are pregnant need to stop using Entresto immediately. Apart from acute renal failure, compromised renal function, and low potassium, the medication may also cause significant harm to the fetus.

    You should call your doctor if you notice any of these side effects or develop other new or concerning symptoms. There are some cases where Entresto is used in pediatric patients. In this case, the patient must be at least one year of age and have symptomatic chronic heart failure. The risk of compromised renal function and acute renal failure is more significant among children who use the sacubitril-valsartan combination. Parents should ensure they know the signs of severe renal impairment. If the child develops severe renal impairment while using the angiotensin ii receptor antagonist combination therapy, they require immediate medical attention.

How to take Entresto (sacubitril valsartan)

Your pharmacist will provide you with instructions on how to take your Entresto prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Entresto can come in different forms and doses, so follow the specific instructions on your prescription. It is typically prescribed once per day. Some particular instructions may include taking drugs with a full glass of water. You can use Entresto with or without some food.

Some people may have difficulty swallowing the sacubitril valsartan tablet. In this case, speak with your doctor. They may advise an oral suspension instead.

What to avoid while taking Entresto (sacubitril valsartan)

Entresto has more than five different drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

If you use any of the following prescription medicines, talk to your doctor:

  • Lithium

  • Diuretics (as part of diuretic therapy)

  • Nonsteroidal anti-inflammatory drugs

  • Aliskiren

Make sure you also consider the potassium supplements that you take. Make sure you also tell your doctor if you use blood pressure medications. They may advise some alterations if you need to use Entresto and have blood pressure problems. Combining blood pressure or other heart failure medications with Entresto can cause more severe renal impairment and other side effects. Do not combine Entresto with other drugs classified as angiotensin ii receptor blockers.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Entresto.

Some research shows that regular alcohol consumption may adversely affect cardiovascular health. Alcohol may cause damage to the heart and increase blood pressure. This causes an increased risk of heart failure complications.

Medication alternatives to Entresto (sacubitril valsartan)

If your healthcare provider prefers to put you on another treatment, they may suggest another angiotensin II receptor blocker or a heart failure medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Entresto prescription FAQs

  • How much does Entresto cost?

    Entresto uses the sacubitril valsartan combination as a treatment procedure for heart failure. This means it may be more costly compared to drugs that only use angiotensin ii receptor antagonists. The price does depend on the dose of the angiotensin ii receptor blocker that the patients treated using.

  • How can I refill my Entresto prescription?

    When you take a sacubitril valsartan combination heart failure therapy drug, then you will need to use it for an extended period. This means your doctor will provide a prescription for around six months, at which time you have to come back for a re-evaluation. To get re-evaluated, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • What should you not take with Entresto?

    Do not combine the use of angiotensin II receptor antagonists with other heart failure therapies. This refers to cases of both chronic and congestive heart failure. Be careful about using this medication with blood pressure drugs, as interactions can occur. If you use medications to treat acute renal failure or similar events, then you should also consult with your doctor.

  • What should I monitor with Entresto?

    You have to carefully monitor renal function periodically. This is due to renal impairment being a potential side-effect of this heart failure medication. Severe renal impairment can occur if you do not take notice of impaired renal function early on.

  • Does Entresto give you more energy?

    It depends on the patients treated. Some patients do experience improvements in energy when they use the angiotensin ii receptor blocker with the additional combination drugs in this medication. The sacubitril valsartan may improve energy due to improvements in the left ventricular ejection fraction.

  • Who should not take Entresto?

    People with severe renal impairment should not use Entresto. The renal impairment may become worse, leading to a clinically significant decrease in overall renal function. You should also not use this drug if you have had problems with a high serum potassium level in the past.

  • What happens if I miss a dose of Entresto?

    If you forget to take this heart failure drug, then take it once you remember about your missed dose. You do need to consider how far apart this dose and your next dose is. If it is too close to the next dose of the ACE inhibitor, then it is a good idea to skip your current dose. Try to drink the sacubitril valsartan combination therapy drug at the same time every day.

  • What happens if I take too much Entresto?

    If you overdose on Entresto, there will be an excessive amount of the sacubitril valsartan combination in your blood system. You should immediately seek medical help to prevent serious complications, such as acute renal failure, from developing.

3 simple steps to request your Entresto prescription today 

Step 1

Book an Entresto prescription request appointment.

You can book a same-day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Entresto prescription.

Speak with a doctor on your smartphone or computer.

Step 3

Pick up Entresto.

We can send prescriptions to any local pharmacy.

Entresto prescription pricing details

How pricing works

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Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

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Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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